Method for preparing rod-shaped hydroxyapatite capable of controlling nano size

A rod-shaped hydroxyapatite, nano-sized technology, applied in medical science, prosthesis, etc., can solve the problems of difficult control of nano-scale crystal structure, poor mechanical properties and biocompatibility, and uncontrollable morphology. Achieve the effects of improving mechanical properties and biocompatibility, regular shape, and uniform size

Inactive Publication Date: 2009-08-19
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the hydroxyapatite synthesized by the above method is difficult to control the nanoscale crystal structure and has uncontrollable defects in shape, which make its mechanical properties and biocompatibility poor.

Method used

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  • Method for preparing rod-shaped hydroxyapatite capable of controlling nano size
  • Method for preparing rod-shaped hydroxyapatite capable of controlling nano size
  • Method for preparing rod-shaped hydroxyapatite capable of controlling nano size

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Slowly add 0.24g 80wt% H3PO4 solution in 20ml concentration of 2wt% chitosan quaternary ammonium salt solution, add dropwise 5mol / l NaOH solution to pH=9 under magnetic stirring, then add 10ml 0.225mol / l CaCl2 dropwise Solution, during which the pH of the system was maintained at 9. After the dropwise addition was completed, the stirring reaction was continued for 0.5h. Then the solution in the reaction system was transferred to a 50ml polytetrafluoroethylene steel autoclave, and reacted at 90°C for 20h. Suction filtration, washing, and drying at 45°C.

[0033] Such as image 3 Shown:

[0034] Infrared spectrum and X-ray diffraction technical characterization results show that the preparation of the present invention is clean, crystalline and rod-shaped hydroxyapatite. Dimensions and aspect ratio see Figure 7 shown.

Embodiment 2

[0036] The preparation method is the same as that of Example 1, as long as the hydrothermal temperature is changed from 90°C to 120°C.

[0037] Such as Figure 4 Shown:

[0038] Morphology of hydroxyapatite. Dimensions and aspect ratio see Figure 7 shown.

Embodiment 3

[0040] The preparation method is the same as that of Example 1, except that the hydrothermal temperature is changed from 90°C to 150°C.

[0041] Such as Figure 5 Shown:

[0042] Morphology of hydroxyapatite. See size and aspect ratio Figure 7 shown.

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Abstract

The invention relates to a method for preparing rod-shaped hydroxyapatite controllable in nanometer size by adopting a hydrothermal method. The method comprises the steps of preparing water-soluble chitosan quaternary ammonium salt from 2,3-epoxypropyltrimethylammonium chloride modified chitosan, taking the chitosan quaternary ammonium salt as a template and adopting the hydrothermal method to prepare nanometer rod-shaped hydroxyapatite. The method solves the defects that the prior precipitation method, hydrothermal method, mechanochemical method, sol-gel method and the like are difficult to control crystal textures in nanometer size scale, uncontrollable in morphology and poor in mechanical properties and biocompatibility. The method has the advantages of preparing crystal-type hydroxyapatite which is pure, controllable in morphology and size and uniform in size positioned in a nanometer range, improving the mechanical properties and biocompatibility of the hydroxyapatite and enabling the hydroxyapatite to be used for preparing inorganic toughening/reinforcing biodegradable osseous-tissue bracket material, along with simplicity, convenient operation and low manufacture cost.

Description

technical field [0001] The invention relates to a method for preparing rod-shaped hydroxyapatite with controllable nanometer size by using a hydrothermal method. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAp) is an important part of the inorganic components in bone tissue, has good biocompatibility and bioactivity, so it is widely used in bone tissue repair. However, because hydroxyapatite is amorphous, its mechanical properties are low, which limits its application in biomimetic biomaterials. Therefore, it is very important to improve the mechanical properties and biocompatibility of hydroxyapatite. [0003] Before the present invention, the current preparation methods of hydroxyapatite mainly include precipitation method, hydrothermal method, mechanochemical method and sol-gel method. However, the hydroxyapatite synthesized by the above method is difficult to control the nanoscale crystal structure and has uncontrollable morphology defect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12
Inventor 朱爱萍陆妍
Owner YANGZHOU UNIV
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