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Medical application of psuedo-ginsenoside F11

A technology for simulating ginsenosides and uses, which is applied in the field of medicinal use of ginsenoside F11, can solve problems such as those not seen, and achieve the effects of less toxic and side effects, significant curative effect and low cost

Active Publication Date: 2009-09-09
李平亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report on the research and application of pseudo-ginsenoside F11 in the treatment of myocardial ischemia, cerebral ischemia and stroke. The new drug of this compound The use is discovered for the first time

Method used

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  • Medical application of psuedo-ginsenoside F11
  • Medical application of psuedo-ginsenoside F11
  • Medical application of psuedo-ginsenoside F11

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0012] Experimental Example 1. Effect of Pseudoginsenoside F11 Injection on Hemorrheology in Rats with Focal Cerebral Ischemia

[0013] 1.1 Materials

[0014] Pseudoginsenoside F11 injection: provided by the Institute of Regenerative Medicine Science, Jilin University, specification: 2ml: 10mg, batch number: 20060701.

[0015] Breviscapine for injection, Yunnan Biopharmaceutical Co., Ltd., specification: 50mg, batch number: 20050616 Wistar rats, half male and half male. Weight 280±20g, purchased from the Experimental Animal Center of the Chinese People's Liberation Army University of Agriculture and Animal Husbandry. Animal certificate number: 10-5112

[0016] Hemorheology tester: Chengdu Massey Science and Trade Co., Ltd.

[0017] 1.2 Methods and results

[0018] 60 rats were randomly divided into sham operation group, model control group, breviscapine group (6mg kg -1 ), Pseudoginsenoside F11 Injection 2.5mg·kg -1 group, 5mg·kg -1 group, 10mg·kg -1 Group. Rat models...

experiment example 2

[0025] Experimental Example 2, Effect of Pseudoginsenoside F11 on Hemorheology of Normal Rats

[0026] 2.1 Materials and methods

[0027] 2.1.1 Animals: wistar rats, provided by the Experimental Animal Center of the University of Agriculture and Animal Husbandry of the Chinese People's Liberation Army, certificate number: 10-5112.

[0028] 2.1.2 Drugs: Pseudoginsenoside F11 (PF11), provided by the Institute of Regenerative Medicine Science, Jilin University, white powder, purity> 98%, dissolved in 1,2-propanediol before the experiment, and then prepared the required concentration with normal saline ; Aspirin (ASP) is a product of Beijing Chemical Plant, batch number: 040814; ADP is produced by Shanghai Boao Biotechnology Co., Ltd., batch number: 040313; Sodium acid is a product of Beijing Chemical Plant, batch number: 040926.

[0029] 4.1.3 Instruments: LBY-N6A rotary blood viscometer; LBY-NJ2 automatic four-channel platelet coagulation instrument; LBY-S5 thrombosis instrume...

experiment example 3

[0050] Experimental Example 3, Effect of Pseudoginsenoside F11 Injection on the Survival Rate of Mice Poisoned by Potassium Cyanide

[0051] 3.1 Materials

[0052] Pseudoginsenoside F11 Injection (PF11), provided by the New Drug Research Office of the Institute of Regenerative Medicine Science, Jilin University, is off-white block, easily soluble in water; when used, it is dissolved and diluted with normal saline to an appropriate concentration. Batch number: 0410231, specification: 2ml: 10mg.

[0053] Potassium cyanide, Taizhou Hengyi Chemical Materials Co., Ltd., batch number: 041010.

[0054] Edaravone injection, Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd., specification: 5ml: 10mg, approval number: Guoyao Zhunzi H20031342, batch number: 20040227.

[0055] 3.2 Method

[0056] Animals were randomly divided into blank control group (normal saline), edaravone group (10 mg·kg -1 ), Pseudoginsenoside F11 Injection 4mg·kg -1 group, 8mg·kg -1 group, 16mg·kg -1 Group, ...

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Abstract

The invention belongs to the technical field of medicaments, and in particular relates to novel medical application of psuedo-ginsenoside F11. Experimental study shows that the psuedo-ginsenoside F11 has good functions for treating myocardial ischemia, cerebral ischemia and stroke, so the active ingredient can be used to prepare medicaments for treating cardio-cerebral vascular diseases, health products, food additives or compound preparations and the like. The psuedo-ginsenoside F11 is mainly used to prepare medicaments for treating or improving symptoms of the myocardial ischemia, the cerebral ischemia and the stroke. The medicaments or health products have all the prior preparation formulations such as tablets, capsules, injections, freeze-dried powders, emulsions for injection, powders, dripping pills, pills, granules, soft capsules, syrups, masticatories and patches.

Description

technical field [0001] The invention relates to the application of pseudo-ginsenoside F11 in the preparation of medicines for treating myocardial ischemia, cerebral ischemia and stroke. Background technique [0002] Since ginsenosides were confirmed as the main active ingredients in ginseng and American ginseng, the biological activity of pseudoginsenoside F11, a unique component of American ginseng, and its application in the field of medicine have attracted people's attention. [0003] The research and reports on pseudo-ginsenoside F11 include: Wu Chunfu, et al. applied for an invention patent on the medical use of pseudo-ginsenoside F11 in detoxification. The results of the study show that pseudo-ginsenoside F11 has anti-morphine-like effects and nootropic effects, which include: 1. Pseudo-ginsenoside F11 can significantly inhibit the memory impairment caused by morphine; significantly antagonize the place preference behavior and morphine-induced autonomous behavior cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/00A61P9/10
Inventor 李平亚刘金平卢丹杜秀娟
Owner 李平亚