Germinal preparation with androgenetic alopecia treatment effect

A technology of androgen source and sodium carboxymethyl cellulose, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, active ingredients of hydroxyl compounds, etc., can solve problems such as sexual dysfunction, achieve small side effects and convenient preparation , good curative effect

Inactive Publication Date: 2012-01-25
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral finasteride has side effects such as decreased sexual function

Method used

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  • Germinal preparation with androgenetic alopecia treatment effect
  • Germinal preparation with androgenetic alopecia treatment effect
  • Germinal preparation with androgenetic alopecia treatment effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Maxwell coffee powder was ultrasonically extracted with deionized water for 2 hours, filtered, and the extract was collected to obtain a water extract of coffee.

[0044] Deionized water has 10 times the weight of coffee powder.

[0045] Concentrate 1000ml of the above-mentioned water extract of coffee to 600ml under reduced pressure, add 360g of ethanol solution with a volume concentration of 95%, 30g of transdermal enhancer menthol and 0.25g of preservative benzalkonium chloride, stir and mix, and obtain the hair growth preparation;

[0046] 5 male patients with mild and moderate hair loss applied the hair growth agent to the hair loss area twice a day, and the dosage was 0.3ml for one application. After 3 months of use, 4 patients got better, and 1 patient showed a marked effect. No side effects were observed.

Embodiment 2

[0048] Nescafe coffee powder was heated and refluxed with 60% ethanol to extract for 3 hours, filtered, and the extract was collected to obtain coffee ethanol extract.

[0049] The weight of ethanol with a volume concentration of 60% is 15 times that of coffee.

[0050] The ethanol extract of the above-mentioned 1000ml coffee was concentrated under reduced pressure to near dryness, and 280g volume concentration of 60% ethanol solution was added, then 50g transdermal accelerator limonene, 200g lanolin, and 550g vaseline were added to make ointment.

[0051] Eight male patients aged 30 to 50 with mild to moderate hair loss applied the hair growth agent twice a day on the hair loss area, and the dosage was 0.2ml once. After 3 months of treatment, 4 of them improved, 2 showed marked effect, and 2 were ineffective, with an effective rate of 75%. %, no side effects were seen.

Embodiment 3

[0053] The Brazilian coffee powder is cold-soaked with ethanol with a volume concentration of 80% for one week, filtered, and the extract is collected to obtain coffee ethanol extract.

[0054] The weight of ethanol with a volume concentration of 80% is 5 times that of coffee.

[0055] Then in the ethanol extract of the above-mentioned 1000ml coffee, add 80g of skin penetration accelerator eucalyptus oil, 1g of sodium sulfite, 0.5g of ethylparaben, and make a spray.

[0056]13 male patients with moderate and severe hair loss applied the hair growth agent to the hair loss area twice a day, and the dosage was 0.5ml once. After 6 months of treatment, 4 people showed obvious results, 7 people improved, the effective rate was 85%, and no side effects were seen.

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Abstract

The invention discloses a germinal preparation with androgenetic alopecia treatment effect. The germinal preparation comprises extracting solution of ethanol-water solution of a therapeutically effective amount of coffee, a pharmaceutically acceptable carrier and other active substances. Tests prove that the germinal preparation with androgenetic alopecia treatment effect has significant effect on treating androgenetic alopecia, and has no toxicity and other side effects, active ingredients of the preparation are derived from natural plant compositions, and the germinal preparation has the advantages of simple preparation, easy use, good curative effect and few side effects.

Description

technical field [0001] The invention relates to a preparation for treating alopecia, in particular to an external preparation capable of treating androgenetic alopecia. Background technique [0002] Androgenetic alopecia is caused by local androgen excess in the scalp, and abnormality of 5a-reductase has an important relationship with the occurrence of the disease. Testosterone in scalp hair follicles is converted into dihydrotestosterone under the action of 5a reductase. Dihydrotestosterone makes hair follicles gradually smaller, reduces pigment production, shortens hair growth phase, and prolongs resting phase, causing hair loss. Therefore, inhibiting the activity of 5a reductase can block the dihydrogenation of testosterone, thereby improving the symptoms of male pattern hair loss. The distribution of 5a reductase in the hair loss area of ​​the patient is high, the activity is high, and the local androgen receptor sensitivity is high. Type II 5a-reductase was distribute...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61P17/14A61K31/58A61K31/506A61K31/203
Inventor 侯惠民吴闻哲于垂亮程志红
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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