Composition to treat and/or prevent gastrointestinal infection

一种组合物、胃肠道的技术，应用在药物组合、食物科学、植物原材料等方向，能够解决转变为人疫苗困难、免疫学所知甚少等问题

Active Publication Date: 2009-09-09
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prophylactic and therapeutic vaccinations have been successful in animal models, but translation to human vaccines remains difficult, in part because the immunology of the stomach remains poorly understood

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: Anti-infective efficacy of protein hydrolyzate components of the present invention

[0051] I. Preparation of anti-attachment peptides and glycoconjugates by enzymatic hydrolysis:

[0052] Pea Protein: Pea protein isolate (90% protein) was dispersed in distilled water to a concentration of 2.5% (w / w). Hydrolysis was carried out at 50° C. for 180 minutes by adding trypsin and chymotrypsin at a weight ratio of 1:150 each enzyme:substrate. During the hydrolysis, the pH was kept constant at pH 7.80 by adding sodium hydroxide. The enzyme was inactivated by heating to 85°C and maintaining between 85°C-80°C for 5 minutes. The suspension was rapidly cooled to room temperature on ice before centrifugation at 3800 xg for 15 minutes at 20°C. Supernatants were collected and lyophilized.

[0053] Camel Casein: Camel casein (85% protein) was dissolved in distilled water to a concentration of 5% (w / w). Hydrolysis was carried out at 37°C for 120 minutes by adding TP...

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PUM

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Abstract

The invention relates to a composition for the treatment and / or prevention of infection by gastrointestinal pathogens, in particular Helicobacter pylori and / or a disease associated with infection by said gastrointestinal pathogen in mammals. The composition comprises a pea protein hydrolysate, intact pea protein and / or camel milk protein hydrolysate.

Description

technical field [0001] The present invention relates to the treatment and / or prevention of gastrointestinal pathogens, especially Helicobacter pylori infection. Background of the invention [0002] Gastrointestinal infections are a major problem for many people, especially infants and patients with compromised immune systems or gastrointestinal disorders. The resulting disease can be life threatening. Escherichia coli, Salmonella, Campylobacter, Clostridium, Enterobacter, and Helicobacter, such as Helicobacter pylori, frequently cause gastrointestinal Infect. [0003] Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic, flagellated bacterium that parasitizes the human gastric mucosa once it infects humans. Helicobacter pylori infection is associated with serious gastric diseases such as gastritis, peptic ulcer and gastric cancer. The World Health Organization has classified Helicobacter pylori as a class I carcinogen. H. pylori infection is usually chron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K38/01A61P31/04A61P1/04
CPCA61K36/48A61K35/20A23L1/3053A23L1/3055A23L1/3056A23L33/18A23L33/185A23L33/19A61P1/00A61P1/04A61P31/04Y02A50/30A61K2300/00
Inventor G·伯姆J·施密特G·格奥尔基M·尤勒
Owner NV NUTRICIA
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