Hubei caval vine general flavone extract as well as preparation method and application thereof

A technology of total flavonoids and extracts, which is applied to the total flavonoids extract of Hubei Begonia and its preparation and application fields, can solve the problem that the effective parts of Hubei Begonia are not clear, the phytochemical and pharmacodynamic research is not systematically carried out, and the effect of Hubei Begonia cannot be reflected. And other issues

Inactive Publication Date: 2009-09-23
SHANDONG UNIV +1
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  • Summary
  • Abstract
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  • Application Information

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Problems solved by technology

This patent is obtained from the compound extraction of Hubei crabapple and other medicinal materials, and cannot reflect the effect of Hubei crabapple
Chinese patent CN101199301 discloses the preparation method of Hubei crabapple brick tea, teabags, concentrated tea tablets and Hubei crabapple pigment, and discloses the application of Hubei crabapple tea in lowering blood sugar a

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  • Hubei caval vine general flavone extract as well as preparation method and application thereof
  • Hubei caval vine general flavone extract as well as preparation method and application thereof

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Embodiment 1

[0028] Embodiment 1: the preparation of total flavonoids extract of Hubei crabapple

[0029] Hubei crabapple branches and leaves 50Kg, reflux extraction with 70% ethanol which is 8 times the weight of the medicinal material, 3 times, 1 hour each time, combine the extracts, filter, and concentrate to extract. Dilute the extract by 10 times with water, adsorb on a macroporous resin column (HPD100, Hebei Baoen Chemical Industry), the ratio of the weight of the original medicinal material to the volume of the macroporous resin is 1:5, the ratio of diameter to height of the chromatographic column is 1:10, and elute with distilled water , the eluate was discarded, and then eluted with 50% ethanol at a flow rate of 1 column volume / hour, the ethanol eluate was concentrated under reduced pressure, and the concentrated solution was spray-dried to obtain that, with a yield of 10.5%.

Embodiment 2

[0030] Embodiment 2: the preparation of total flavonoids extract of Hubei crabapple

[0031] Hubei crabapple branches and leaves 50Kg, reflux extraction with 70% ethanol which is 8 times the weight of the medicinal material, 3 times, 1 hour each time, combine the extracts, filter, and concentrate to extract. Dilute the extract by 10 times with water, and absorb it on a polyamide column (60-90 mesh). Discarded, then eluted with 50% ethanol, the flow rate was 1 column volume / hour, the ethanol eluate was concentrated under reduced pressure, and the concentrated solution was spray-dried to obtain the obtained product with a yield of 9.6%.

Embodiment 3

[0032] Embodiment 3: the preparation of total flavonoids extract of Hubei crabapple

[0033] 50Kg of branches and leaves of Begonia chinensis in Hubei were reflux extracted with 95% ethanol equal to the weight of the medicinal materials for 8 times, each time for 5 hours, the extracts were combined, filtered, and concentrated to extract. The extract is diluted 20 times with water, and adsorbed on a macroporous resin column (HPD100, Hebei Baoen Chemical Industry Co., Ltd.). The ratio of the weight of the original medicinal material to the volume of the macroporous resin is 1:10 (g:ml), and the diameter-to-height ratio of the chromatographic column is 1:20. , eluted with distilled water, the eluent was discarded, and then eluted with 95% ethanol at a flow rate of 2 column volumes / hour, the ethanol eluate was concentrated under reduced pressure, and the concentrated solution was spray-dried to obtain that, with a yield of 8.0%.

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Abstract

The invention discloses a Hubei caval vine general flavone extract which is prepared by the following method: firstly, using ethanol to extract; then using a macroporous resin column or a daiamid column to adsorb; using the ethanol to elute; and collecting the ethanol eluting liquid to carry out vacuum concentration or vacuum drying or spray drying or freeze drying so as to obtain the Hubei caval vine general flavone extract. The content of general flavone in the Hubei caval vine general flavone extract is more than 50 percent, and the total content of phlorizin of a dihydrochalcone compound and 3-hydroxybenzoate phlorizin is more than 40 percent, wherein the mass ratio of the phlorizin to the 3-hydroxybenzoate phlorizin is 20:1-5:1. The obtained Hubei caval vine general flavone extract has low toxicity and can be used for preparing medicaments for treating type II diabetes mellitus.

Description

technical field [0001] The invention relates to a Hubei crabapple total flavonoid extract and a preparation method and application thereof. Background technique [0002] Diabetes, known as diabetes in traditional Chinese medicine, is a series of clinical syndromes caused by absolute or relative insufficiency of insulin in the body. Diabetes is a common, multiple, and lifelong disease. The incidence of diabetes in the world is increasing year by year, and it has been listed as the third largest disease after cardiovascular diseases and tumors in developed countries. At present, the greatest hazard of diabetes to human health is the various chronic complications based on arteriosclerosis and microvascular disease, such as diabetic heart disease, diabetic gangrene, diabetic cerebrovascular disease, diabetic nephropathy, diabetic retina disease and neuropathy. The number of blindness caused by diabetes is 10-25 times more than the average person. At present, diabetic retinopat...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P3/10A61K127/00A61K135/00
Inventor 娄红祥任冬梅王姝麒
Owner SHANDONG UNIV
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