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Application of 28 alkanol as anti-Parkinson's disease substance in medicaments and health care products

A technology for Parson's disease and health care products, which is applied in the field of 28 alkanols and their derivatives or their pharmaceutical compositions, can solve the problem of limited application, survival, effect, difficult clinical promotion of cell sources, can not prevent disease development, late stage Invalid, etc.

Inactive Publication Date: 2009-09-30
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a lot of new progress has been made in drug research on PD, the adverse reactions of these drugs limit their application
At the same time, these drugs can only improve the symptoms of PD, but cannot affect the progress of the disease
The traditional treatment plan for PD is based on levodopa (L-3,4-dihydroxyphenylethylamine, L-DOPA), but there are problems such as it cannot prevent the development of the disease, and it is ineffective in the later stage.
Implanting DA-producing cells into the brain also has a certain curative effect, but it is currently difficult to promote clinically due to issues such as survival, efficacy, and cell sources.

Method used

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  • Application of 28 alkanol as anti-Parkinson's disease substance in medicaments and health care products
  • Application of 28 alkanol as anti-Parkinson's disease substance in medicaments and health care products
  • Application of 28 alkanol as anti-Parkinson's disease substance in medicaments and health care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: 28 Alcohol Effects on the Behavior of MPTP-induced Parkinson's Disease Mouse Model

[0037] 1. Materials and methods

[0038] 1. Materials

[0039] 1.1 Test product: 28 alcohol, white powder or scaly crystal, provided by Xuzhou Normal University, soluble in hot organic solvents such as ethanol, ether, benzene, toluene, chloroform, methylene chloride, etc., insoluble in water. It is stable to acid, alkali and reducing agent. It mainly exists in rice bran wax, sugarcane wax and sunflower oil wax. It is made into suspension with 0.5% CMC (sodium methylcellulose) water-assisted solution.

[0040] 1.2 Reagent: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), product of Sigma Company, product number M0896, batch number 095K1166.

[0041] 1.3 Positive control drug: levodopa tablets, produced by Beijing Shuguang Pharmaceutical Co., Ltd., batch number 060517.

[0042] 1.4 Animals: C57BL / 6 mice, male, weighing 24.5±0.8g, provided by Beijing Weitong Lihua Animal ...

Embodiment 2

[0063] Embodiment 2: The effect of 28 alcohol on the behavior of 6-OHDA-induced Parkinson's disease (PD) rat model

[0064] Research

[0065] 1. Materials and methods

[0066] 1. Materials

[0067] 1.1 Test product: 28-alcohol, white powder or scaly crystal, provided by Xuzhou Normal University. Soluble in ethanol, ether, benzene, toluene, chloroform, methylene chloride and other organic solvents, insoluble in water. It is stable to acid, alkali and reducing agent, and mainly exists in rice bran wax, sugarcane wax and sunflower oil wax. 0.5% CMC (Sodium Methylcellulose) was dissolved in water to make a suspension.

[0068] 1.2 Reagents: 6-hydroxydopamine (6-OHDA), product of Sigma Company, product number H116, lot number 115K4613; apomorphine (APO), product of Sigma Company, product number A4393, lot number 085K1223.

[0069] 1.3 Animals: SD rats, male, weighing 203.0g±7.9g, provided by Beijing Weitong Lihua Animal Company.

[0070] 2. Method

[0071] 2.1 Establishment ...

Embodiment 3

[0112] Example 3: The effect of 28 alkanol on the viability of SH-SY5Y cells and on DA and MPP + Protective effect of induced SH-SY5Y cell injury model

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Abstract

The invention discloses application of 28 alkanol as an anti-Parkinson's disease substance in medicaments and health care products, in particular application in preparing medicaments and health care products for treating and preventing Parkinson's disease, complicating diseases and other related diseases. The invention also discloses a pharmaceutical composition for resisting the Parkinson's disease, which comprises the 28 alkanol and derivatives thereof and a pharmaceutically acceptable carrier. The pharmaceutical composition comprises tablets, capsules, pills, injection, sustained-release preparations, controlled release preparations and particulate delivery systems.

Description

technical field [0001] The present invention relates to 28-alkanol and its derivatives or pharmaceutical composition thereof, as anti-Parson's disease substances in medicine and health products, especially for the preparation of medicines and health products for the treatment and prevention of Parson's disease The use of medicines and health products for related diseases such as its complications. Background technique [0002] Parkinson's disease (Parkinson's disease, PD) is a degenerative disease of the central nervous system, also known as "parkinson's paralysis", which was first proposed by James Parkinson in 1817. The disease is characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra of the midbrain and a significant reduction in DA content in the striatum, and at the same time, ubiquitinated protein deposits, namely Lewy bodies, are produced in the neuron cytoplasm. Gliosis in the substantia nigra and striatum is another prominent neuropath...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P25/16
Inventor 朱海波蒋继宏冯友建何放亭赵大龙张岭渠凯
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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