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Clinopodium polycephalum total aglycone oral pharmaceutical preparation as well as preparation method and application thereof

A technology of cutting off blood flow and medicine, which is applied in the field of extracting total aglycone from blood flow, and can solve the problems of ignoring the research, effect and application status of total aglycone on blood flow cutting off.

Inactive Publication Date: 2009-09-30
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing technology has neglected the research on the total aglycone in blood flow, and its effect and application have been in a blank state.

Method used

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  • Clinopodium polycephalum total aglycone oral pharmaceutical preparation as well as preparation method and application thereof
  • Clinopodium polycephalum total aglycone oral pharmaceutical preparation as well as preparation method and application thereof
  • Clinopodium polycephalum total aglycone oral pharmaceutical preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Take 100g of total aglycon from blood flow, add chitosan 20g, polyvinylpyrrolidone 20g, carbomer 10g, poloxamer 50g, lecithin 50g, micronized silica gel 50g, beta cyclodextrin 100g, starch 100g, shake Mill and superfinely pulverize and mix for 30 minutes, then separate into powders.

Embodiment 2

[0081] Take 70g of blood flow total aglycone and 10g of white peony aglycone, add 5g of chitosan, 5g of carbomer, 14g of poloxamer, 10g of lecithin, 10g of micronized silica gel, 20g of betacyclodextrin, and carboxymethyl Starch sodium 6g, microcrystalline cellulose 50g, superfine pulverization by weight-type grinding ultramicrocomputer for 30 minutes, add 70% ethanol for 10 minutes, make pellets, divide and round, dry, polish, divide, and make Into a pill.

Embodiment 3

[0083] Take 120 g of total aglycone from the blood flow, add 2 g of chitosan, 10 g of lecithin, 66 g of dextrin, 2 g of aspartame, stir evenly, dry press to granulate, and divide into granules to prepare granules.

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Abstract

The invention relates to a clinopodium polycephalum total aglycone oral pharmaceutical preparation as well as a preparation method and an application thereof, belonging to the field of traditional Chinese medicines. Total aglycone extracted from clinopodium polycephalum is hydrolyzed to obtain clinopodium polycephalum total aglycone, and the clinopodium polycephalum total aglycone is made into an efficient preparation by matching with a special auxiliary material, thereby the bioavailability of the clinopodium polycephalum total aglycone can be greatly improved. The preparation has obvious curative effect in the aspect of curing disease symptoms, such as anti-inflammatory and / or trauma, nosebleed, obstetrical hemorrhage, and the like.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine blood flow cut extract, in particular to a blood flow cut total aglycon extract, and the medicinal use of the extract. It belongs to the field of Chinese medicine. Background technique [0002] The traditional Chinese medicine cut blood flow, also known as the shade wind wheel, is the dry aerial part of Clinopodium polycephalum (Vaniot) C.Y.Wu et Hsuan or wind wheel Clinopodi-um chinensis (Benth.) O.Kuntze. Mainly distributed in my country's Jiangsu, Anhui, Guangxi, Guizhou, Yunnan, Sichuan and other places. Harvest before blooming in summer, remove the sediment, and dry in the sun. The medicinal material is mainly used for anti-inflammatory and treatment of various bleeding diseases such as knife and axe wounds, nosebleeds, and gynecological bleeding. It is included in the Chinese Pharmacopoeia. The medicinal materials contain a large number of glycosides, including flavonoid glycosides, saponins, iri...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/20A61K9/48A61K9/16A61K47/38A61K47/36A61K47/32A61K47/40A61K47/34A61K47/24A61K47/10A61P29/00A61P15/00A61P17/02A61P7/04
Inventor 张峰刘国飞
Owner 北京凯瑞创新医药科技有限公司
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