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Dispersing tablet containing terbinafine hydrochloride

A technology of terbinafine hydrochloride and dispersible tablets, which is applied in the field of medicine, can solve the problems that capsules do not have quick-acting and instant-dissolving properties, and achieve the effects of rapid dissolution, convenient administration, and simple production process

Active Publication Date: 2009-10-07
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] A capsule preparation of terbinafine hydrochloride is disclosed in CN1440746A. Compared with dispersible tablets, the capsule does not have the characteristics of fast-acting and instant-dissolving, and is not suitable for those who have difficulty swallowing

Method used

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  • Dispersing tablet containing terbinafine hydrochloride
  • Dispersing tablet containing terbinafine hydrochloride
  • Dispersing tablet containing terbinafine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation process: Weigh terbinafine hydrochloride, lactose, mannitol, microcrystalline cellulose, and croscarmellose sodium according to the prescription amount, mix well, make soft material, pass through a 20-mesh sieve to granulate, dry, 24 Mesh sieve for granulation; add magnesium stearate and citric acid in prescription ratio, mix evenly, and compress into tablets.

Embodiment 2

[0024]

[0025] Preparation process: Weigh terbinafine hydrochloride, lactose, xylitol, povidone, and sodium carboxymethyl starch according to the prescription quantity, mix well, make soft material, pass through a 20-mesh sieve to granulate, dry, and sieve through a 24-mesh sieve granules; add grape essence and magnesium stearate in the prescribed ratio, mix evenly, and compress into tablets.

Embodiment 3

[0027]

[0028] Preparation process: Weigh terbinafine hydrochloride, polyethylene glycol, mannitol, low-substituted hydroxypropyl cellulose, and sucrose according to the prescription quantity, mix well, make soft material, granulate through a 20-mesh sieve, dry, 24-mesh Sieve whole grains; add cantaloupe essence and magnesium stearate in the prescribed ratio, mix well, and press into tablets.

[0029] Embodiment 1~3 compares with comparative example 1, commercially available common tablet dissolution rate (n=6, X ± SD)

[0030]

[0031] The results show that: the dissolution rate of the dispersible tablet at each time point is significantly higher than that of the commercially available common tablet, and the dissolution rate of the sample prepared in Example 1 is better than that of the sample of Comparative Example 1 at each time point.

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Abstract

The invention discloses a dispersing tablet containing terbinafine hydrochloride. The dispersing tablet comprises active components of the terbinafine hydrochloride and medical auxiliary materials and is clinically used for killing or inhibiting fungus.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a dispersible tablet containing terbinafine hydrochloride. Background technique [0002] Terbinafine hydrochloride ((E)-N-(6,6-dimethyl-2-hepten-4-yne)-N-methyl-1-naphthylmethylamine hydrochloride) is a broad-spectrum antifungal Active allylamine drugs, this product can specifically interfere with the early biosynthesis of fungal sterols, highly selectively inhibit fungal squalene epoxidase, and make squalene epoxidation reaction in the process of fungal cell membrane formation Blocked, so as to achieve the effect of killing or inhibiting fungi, the curative effect is definite, and the toxic and side effects are mild, and has broad development prospects. [0003] Conventional preparations of terbinafine hydrochloride are mainly for external use, and for oral preparations, only ordinary tablets and capsules are currently used clinically. Terbinafine hydrochloride is a poorly s...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/137A61K47/38A61K47/36A61P31/10
Inventor 吕青远
Owner AVENTIS PHARMA HAINAN
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