Synthetic process for vitamin C sodium salts

A synthesis process and vitamin technology, applied in the field of vitamin C sodium salt synthesis technology, can solve the problems of long synthesis time, grayish-yellow color, poor quality, etc., and achieve the improvement of production efficiency and equipment utilization, short synthesis time, and improved purity. Effect

Active Publication Date: 2009-10-07
徐建涛
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this process is that the synthesis time is long, the single batch synthesis time is between 10 and 12 hours, and the product content is low, the quality is

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthetic process for vitamin C sodium salts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Vitamin C sodium salt synthesis technique of the present invention, carry out according to the following steps successively:

[0016] (1) Gulonic acid is dissolved in 99% methanol with a weight ratio of 3.5 times at a temperature of 35° C., then passes through a filter with a pore size of 30 μm, and then passes through a filter with a pore size of 0.05 μm and a layer of powdered activated carbon for gradient decolorization to obtain a decolorizing solution stand-by;

[0017] (2) Under the temperature of 75°C and the pressure of 0.15±0.1Mpa, the decolorizing solution is circulated in the macroporous hydrogen resin for 1.5 hours to obtain the esterification reaction solution;

[0018] (3) Inject the esterification reaction liquid into the normal pressure container, keep stirring at a temperature of 70±2°C, mix sodium bicarbonate (0.505 times the molar amount of gulonic acid) with 99 % weight concentration of methanol was mixed to obtain a suspension, which was added to t...

Embodiment 2

[0020] Vitamin C sodium salt synthesis technique of the present invention, carry out according to the following steps successively:

[0021] (1) Gulonic acid is dissolved in the methanol of 99% weight concentration of 3 times of weight ratio at 28 DEG C of temperature, then pass through the filter of 20 μm aperture, then pass through the filter of 0.01 μm aperture and powder activated carbon layer gradient decolorization to obtain decolorization liquid stand-by;

[0022] (2) Under the temperature of 76°C and the pressure of 0.15±0.1Mpa, the decolorizing solution is circulated in the macroporous hydrogen resin for 1.6 hours to obtain the esterification reaction solution;

[0023] (3) The esterification reaction liquid is injected into the normal pressure container, and at a temperature of 70±2° C., keeping stirring, the sodium bicarbonate of 1.03 times the molar number of gulonic acid or the sodium carbonate of 0.508 times the molar number of guaronic acid are mixed with 99% we...

Embodiment 3

[0025] Vitamin C sodium salt synthesis technique of the present invention, carry out according to the following steps successively:

[0026] (1) Gulonic acid is dissolved in 99% methanol with a weight ratio of 4 times at a temperature of 32° C., then passes through a filter with a pore size of 15 μm, and then passes through a filter with a pore size of 0.09 μm and a layer of powdered activated carbon for gradient decolorization to obtain a decolorizing solution stand-by;

[0027] (2) Under the temperature of 78°C and the pressure of 0.15±0.1Mpa, the decolorizing solution is circulated in the macroporous hydrogen resin for 1.8 hours to obtain the esterification reaction solution;

[0028] (3) The esterification reaction solution is injected into the normal pressure container, and at a temperature of 70±2° C., and kept in a stirring state, sodium bicarbonate with 1.05 times the molar number of gulonic acid or sodium carbonate with 99% weight concentration The suspension mixed w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a synthetic process for vitamin C and sodium salts, which pertains to the technical field of chemistry. Gulonic acid and methanol carry out esterification reaction and then react with the sodium salts. The synthetic process is characterized by be executed according to the following steps: (1) the gulonic acid is dissolved in methanol and then goes through a filter with the aperture ranging from 1 Mum to 50 Mum and goes through a filter with the aperture ranging from 0.01 Mum to 1 Mum and a powdered activated carbon layer for gradient decolorization, thus obtaining a destaining solution for further use; (2) the destaining solution circularly reacts for 1.2 hours to 1.8 hours in macroporous hydrogenous resin, thus obtaining esterification solution; (3) the esterification solution is injected into a normal pressure container, kept being stirred at the temperature of 70 DEG C plus or minus 2 DEG C and uniformly added with suspending liquid obtained by mixing sodium bicarbonate with the mole number of 1.01 times to 1.05 times of the gulonic acid or the sodium carbonate with the mole number of 0.505 time to 0.51 time of the gulonic acid with methanol, and then is cooled to the room temperature after thermal insulation is executed continuously, thus obtaining the vitamin C sodium salts after centrifugal dehydration. The process has short synthesis time, products with high purity and good quality, and low energy consumption.

Description

technical field [0001] The invention relates to a synthesis process of vitamin C sodium salt, which belongs to the technical field of chemical industry. Background technique [0002] Vitamin C sodium salt is a commonly used food additive and medicine. At present, the commonly used synthesis process is to combine guronic acid, methanol, and 98% concentrated sulfuric acid in a ratio of 1:4.5:0.025 by weight at 68-72°C under normal pressure. After carrying out the esterification reaction for 4 to 5 hours, after cooling to 50 to 55°C, add sodium bicarbonate in moles equal to the sum of the moles of gulonic acid and 1 / 2 the moles of concentrated sulfuric acid, and then heat up to 65 to 72°C After reacting for another 4-5 hours, cool to room temperature, and then dehydrate to obtain a wet product of vitamin C sodium. The content of the wet product is about 65-75%, and the content after drying is about 85-89%. The disadvantage of this process is that the synthesis time is long, th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D307/62A23L1/302A61K31/375A23L33/15
Inventor 徐建涛
Owner 徐建涛
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap