Compound eardrops containing antipyrine and lidocaine the and preparation method thereof

A technology of lidocaine and antipyrine, applied in the field of compound ear drops containing antipyrine and lidocaine and its preparation, can solve hormone drug dependence, systemic hormone reaction, ineffective effect Excellent, athletes positive for stimulants and other issues, to achieve obvious analgesic effect, good cure rate, remarkable effect

Active Publication Date: 2009-11-25
NAVY MEDICINE RES INST OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the application of glucocorticoids can help the treatment of otitis media, long-term use will cause adverse consequences such as hormone drug dependence and systemic hormone reactions, and it is not suitable for sports athletes. After use, it may cause athletes Doping test positive
Commonly used clinical otitis media treatment methods are not effective in analgesia

Method used

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  • Compound eardrops containing antipyrine and lidocaine the and preparation method thereof
  • Compound eardrops containing antipyrine and lidocaine the and preparation method thereof
  • Compound eardrops containing antipyrine and lidocaine the and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Antipyrine 4g

[0042] Lidocaine Hydrochloride 1g

[0043] Sodium thiosulfate 0.1g

[0044] 95 (volume)% ethanol 24g

[0045] Glycerin 70.9g

[0046] Dissolve antipyrine and lidocaine hydrochloride in ethanol solution to make a solution, then add sodium thiosulfate to the above solution, mix well, add glycerin, mix well and dissolve, and obtain ear drops.

[0047] The ear drops can be dripped into the external auditory canal for administration and treatment of the external auditory canal.

Embodiment 2

[0049] Antipyrine 4g

[0050] Lidocaine Hydrochloride 1g

[0051]Sodium thiosulfate 0.5g

[0052] 95 (volume)% ethanol 20g

[0053] Glycerin 74.5g

[0054] The preparation method is the same as in Example 1.

Embodiment 3

[0056] Antipyrine 4g

[0057] Lidocaine Hydrochloride 2g

[0058] Sodium thiosulfate 0.2g

[0059] 75 (volume)% ethanol 25g

[0060] Glycerin 68.8g

[0061] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses compound eardrops containing antipyrine and lidocaine and a preparation method thereof, which includes: antipyrine, lidocaine and pharmaceutically acceptable excipients, and contains 1%-20% antipyrine and 0.5%-5% lidocaine or salts thereof by total weight of compound eardrops. The compound eardrops containing antipyrine and lidocaine provided by the invention has the advantages of rapid action, fast effect, low cost, convenient usage, simple preparation, controllable quality as well as good antibacterial and anti-inflammatory effects for middle ear barotraumas and acute and chronic otitis media, especially good recovery rate for middle ear barotraumas, and the compound eardrops has obvious analgesic effect for reducing earache, headache and other uncomfortable feelings of patients.

Description

technical field [0001] The invention relates to an ear drop, in particular to a compound ear drop containing antipyrine and lidocaine and a preparation method thereof. Background technique [0002] Acute and chronic otitis media are common and frequently-occurring diseases in clinical otology. Most of the pathogenic bacteria are Staphylococcus aureus, Pseudomonas aeruginosa, hemolytic streptococcus, Proteus, etc. Some otitis media may be accompanied by anaerobic bacteria, etc. Symptoms include temporary hearing loss and pain in the affected ear, or accompanied by fever, examination shows sunken or bulging or perforated tympanic membrane, disappearance of tympanic membrane light cone, middle ear effusion or effusion, tympanic membrane hyperemia or hemorrhage, and even In the case of tympanic membrane perforation, exudate or pus can be seen, and there is tenderness in the external auditory canal, mastoid, etc., or palpable enlarged lymph nodes around the ear, or accompanied by...

Claims

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Application Information

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IPC IPC(8): A61K31/4152A61K31/167A61P27/16A61P29/00
Inventor 巴剑波陈双红陈锐勇武文斌徐雄利孙锦程郝蕙玲
Owner NAVY MEDICINE RES INST OF PLA
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