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Borate biological microcrystalline glass, preparation method and application thereof

A technology of glass-ceramics and borate, applied in bone implants, medical science, prostheses, etc.

Inactive Publication Date: 2009-12-09
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, there is no report on the borate bioglass-ceramic that can generate hydroxyapatite on the surface of the material in the simulated body fluid SBF solution with adjustable rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Accurately weigh the raw materials according to the composition ratio shown in Table 1, stir the raw materials, put them into a quartz crucible, raise the temperature to 200 °C in a muffle furnace at a slow heating rate of 2 °C / min, and keep the temperature for 4 hours; from the quartz crucible Take out, pulverize and grind, melt in a platinum crucible, the melting temperature is 1200°C, and the holding time is 2 hours; press and quench the prepared melt between metal molds, and precipitate the soda calcium stone crystals during the cooling process It is the product of the present invention. Cut, grind and polish the glass-ceramic sample with a certain thickness and diameter (it is a conventional technical requirement). Table 2 shows the test results of glass-ceramic melting and properties. The transition temperature and crystallization temperature of glass are tested by differential thermal analysis, a traditional test method in the glass industry, and the test instru...

Embodiment 2

[0049] Accurately weigh the raw materials according to the composition ratio shown in Table 1, except that the pre-sintering temperature is 190°C, the melting temperature is 1100°C, and the holding time is 2.5 hours. The melt is pressed and quenched between the metal molds, and phosphorus is precipitated during the cooling process. Except soda limestone crystal, all the other are identical with embodiment 1. Test is identical with embodiment 1, and result is shown in table 2. After soaking in the simulated body fluid for 24 hours, hydroxyapatite was formed on the surface of the glass-ceramic. The cell culture test results showed that there was no cell death. The cells began to adhere to the material after 1 hour, and the cells were completely adsorbed after 24 hours. Covers the surface of the material and reproduces and grows rapidly.

Embodiment 3

[0051] The raw materials were accurately weighed according to the composition ratio shown in Table 1, except that the pre-sintering temperature was 210°C, the melting temperature was 1000°C, and the holding time was 2 hours, except that the annealing temperature was 500°C, and the annealing time was 2 hours. The annealed glass was heat-treated at 700° C. for 2 hours except that the glass was devitrified, and the rest was the same as in Example 1. Test is identical with embodiment 1, and result is shown in table 2. After soaking in the simulated body fluid for 24 hours, hydroxyapatite was formed on the surface of the glass-ceramic. The cell culture test results showed that there was no cell death. The cells began to adhere to the material after 1 hour, and the cells were completely adsorbed after 24 hours. Covers the surface of the material and reproduces and grows rapidly.

[0052] Table 1 Components of Example Glass

[0053] Glass component (wt%)

[0054] ...

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Abstract

The invention relates to glass-ceramic, in particular to borate biological microcrystalline glass, a preparation method and application thereof. The invention adopts the following technical scheme: the borate biological microcrystalline glass comprises the following components in percentage by weight: 30-60 percent of B2O3, 10-40 percent of Na2O, 10-30 percent of CaO, 10-30 percent of P2O5 and 0-20 percent of F, wherein the weight ratio of the Na2O to the CaO is 1:2, and the weight ratio of the CaO to the P2O5 is 1:2. The invention has the advantages that a crystalline phase of the borate biological microcrystalline glass is mainly canaphite namely beta-NaCaPO4, and a glass phase is Na-Ca-B glass. The Na-Ca-Bglass phase has higher degradation rate in an SBF solution so as to ensure that a glass-ceramic material can be quickly converted into a hydroxylapatite material, and the rate of generating the hydroxylapatite can be adjusted.

Description

technical field [0001] The invention relates to a glass-ceramic, in particular to a borate biological glass-ceramic and its preparation method and application. Background technique [0002] In the early 1870s, Professor Hench of the University of Florida in the United States discovered bioactive glass and applied it to the field of biomedicine for the first time, thus creating a new field of biomaterial research. As a biomedical material, this kind of material has the incomparable advantages of metals, polymers and biologically inert materials. It is firmly combined with the surrounding bone, has no rejection reaction when implanted into the bone, is harmless to the human body, non-toxic, and has higher mechanical strength than natural bone. , and there is no intensity fatigue in the human body, easy to sterilize and easy to form and process. [0003] In recent years, some bioactive glasses with bioactivity and high mechanical strength have been developed, represented by th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61F2/28
Inventor 梁文屠轶凡占磊张爱平周奂君刘昌胜
Owner EAST CHINA UNIV OF SCI & TECH
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