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Iron (II)-threonine and preparation method and application thereof

A technology of ferrous threonine and threonine, applied in the fields of application, cyanide reaction preparation, chemical instruments and methods, etc., can solve the problems of poor solubility of solid threonine, complicated operation process, and low biological potency , to achieve the effect of improving anti-stress ability, improving growth performance and high biological potency

Active Publication Date: 2011-08-31
XINGJIA BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an essential trace element for animals, iron is mostly used as an animal feed additive in the form of inorganic salts of iron. Animals must pass through various biological barriers when absorbing and utilizing it. Part of it is excreted through feces, pollutes the environment, and has a destructive effect on active substances such as vitamins in the feed
There is also an operation method of using solid threonine and inorganic iron as a feed additive to supplement the nutrition of threonine, but the operation process is complicated and the solubility of solid threonine is poor

Method used

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  • Iron (II)-threonine and preparation method and application thereof
  • Iron (II)-threonine and preparation method and application thereof
  • Iron (II)-threonine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A ferrous threonine finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve to replace the air in the reaction kettle, then under the protection of nitrogen, first take 47.64g threonine and put it into a container containing 150g reaction water. Fully stir in the reaction kettle, then put 55.6g of ferrous sulfate heptahydrate, adjust the pH value of the reaction mixture to 6.5 with 13.83g of sodium hydroxide at 90°C, react for 2h under normal pressure, and then send the reaction product to In the concentration tank, at 0.5kgf / cm 2 Vacuum concentration is carried out under a certain degree of vacuum, the concentration temperature is 80°C, and the concentration time is 30 minutes. After the product is viscous, the concentrate is fed into the tray, flashed and dried at 100°C, and crushed to prepare Ferrous threonine finished product.

[0028] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the ...

Embodiment 2

[0035]A ferrous threonine finished product of the present invention is prepared through the following steps: first open the nitrogen valve to replace the air in the reactor, then under the protection of nitrogen, first take 39.70g of threonine and put it into a tank containing 150g of reaction water. Fully stir in the reaction kettle, then drop 23.17g ferrous sulfate monohydrate, adjust the pH value of the reaction mixture to 6.8 with 11.52g sodium hydroxide at 85°C, react for 2.5h under normal pressure, and then use the reaction product Extract with ethanol for 30 minutes, and the volume ratio of ethanol to reaction product is 9:1. The precipitate after extraction is dried at 120° C. in an instant by air flow, and crushed to prepare ferrous threonine product.

[0036] Gel filtration chromatography (GB / T 13080.2-2005) is used to detect the chelation rate in the finished product, and the values ​​are all above 80%.

[0037] The feed additive ferrous threonine finished product p...

Embodiment 3

[0043] A ferrous threonine finished product of the present invention is prepared through the following steps: firstly open the nitrogen valve to replace the air in the reactor, then under the protection of nitrogen, first take 240Kg of threonine and put it into a tank containing 1000kg of reaction water. Fully stir in the reaction kettle, then put in 278Kg ferrous sulfate heptahydrate, adjust the pH value of the reaction mixture to 6.5 with 70kg sodium hydroxide at 85°C, react for 1.5 hours under normal pressure, and then send the reaction product to concentrate In a tank, at 0.7kgf / cm 2 Vacuum concentration is carried out under a certain degree of vacuum, the concentration temperature is 90°C, and the concentration time is 40 minutes. After the product is viscous, the concentrate is fed into the tray, flashed and dried at a temperature of 100°C, and prepared after crushing. Obtain ferrous threonine finished product.

[0044] Gel filtration chromatography (GB / T 13080.2-2005) ...

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Abstract

The invention discloses a threonine chelate of iron (II)-threonine and the preparation method comprises the following steps: mixing the ferrous sulphate with threonine aqueous solution according to a mole ratio of (0.5-1.1):2 to react at 60-100 DEG C and with a pH value of 4-8 for 0.5-6h under protection of inert gas and obtaining a reaction product; vacuum concentrating or extracting the reaction products with an organic solvent, drying and crushing to obtain the finished product iron (II)-threonine. The iron (II)-threonine of the invention can be used as the animal feed additive so that theaim to effectively promote the growth of the animal, strengthen the resistance of the animal and improve the utilization efficiency of animal feed can be realized.

Description

technical field [0001] The invention relates to a feed additive and a preparation method thereof, in particular to an amino acid chelate compound, a preparation method and application thereof. Background technique [0002] Threonine is an important nutritional enhancer, which can strengthen the nutrition of grains, cakes, dairy products, etc. Threonine, like tryptophan, also has the functions of restoring human fatigue and promoting growth and development. In medicine, because the structure of threonine contains hydroxyl groups, it has a water-holding effect on human skin. After combining with oligosaccharide chains, it can play an important role in protecting cell membranes; threonine can also promote phospholipid synthesis and fatty acid oxidation in the body , and its preparation has medicinal effects such as promoting human growth and anti-fatty liver, and is often used as a component of compound amino acid infusion. At the same time, threonine is also the basic raw ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/76C07C227/18A23K1/16A23K20/142
Inventor 黄逸强
Owner XINGJIA BIO ENG CO LTD
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