Compound niclosamide parasite-expelling tablet used for pet and preparation method thereof

Abstract

The invention relates to a compound niclosamide parasite-expelling tablet used for pet. The compound niclosamide parasite-expelling tablet used for pet is characterized by comprising the following components according to the mass percent respectively: 68 to 80 of niclosamide, 3 to 5 of hydrochloric acid levamisole, 13 to 20 of starch, 0.1 to 1 of polyethylene glycol 4000 used for preparing aqueous ethanol solution, 3 to 6 of sodium carboxymethyl starch and 0.5 to 1 of magnesium stearate. In preparation, the niclosamide is weighed, the starch is added, and a mixture is prepared by mixing, pulverization and sieving; and the hydrochloric acid levamisole is dissolved in the aqueous ethanol solution, the polyethylene glycol 4000 is dissolved, then the aqueous ethanol solution is added into the mixture, a soft material is prepared, granulated by using a sieve and dried at 50 DEG C to 70 DEG C, the obtained dry particles are granulated by the sieve, the magnesium stearate and the sodium carboxymethyl starch are added, and the obtained mixture is evenly mixed and tabletted to obtain a product. The tablet has bright and clean appearance, rapid disintegration, good parasite-expelling effect after oral administration, simple technology and low cost, is feasible and is suitable for industrialized production, and each index of the tablet reaches optimization.

Description

technical field [0001] The invention relates to a compound niclosamide deworming tablet for pets and a preparation method thereof. Background technique [0002] The first need in veterinary parasitology is the development of new antiparasitic drugs. However, the development of new drugs requires a huge amount of money, and it takes a long time for each new drug to go through research to final registration and marketing. On the basis of the original drugs, developing various formulations and using existing drugs and new technologies to prepare compound preparations is a research direction for the development of new drugs. The results of clinical research prove that the compound preparation has the same high curative effect as single-dose medicine, less adverse drug reactions, and convenient administration. In daily prevention and treatment, it is easier to avoid missed doses and ensure the rationality of medication. Due to its own characteristics, pets do not use their rati...

AI Technical Summary

Problems solved by technology

In my country, both niclosamide and levamisole hydrochloride are varieties recorded in the 2005 edition of the Chinese Veterinary Pharmacopoeia, and their single preparations have been produced in large quantities, and their compound preparations have not yet been reported and sold.