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Surface treatment method for improving biological property of medical metallic titanium

A surface treatment, titanium metal technology, applied in the field of titanium dioxide film, can solve the problems of limited improvement of biological properties, low controllability of substrate morphology, long time consumption, etc., to achieve excellent biological activity, improve biocompatibility and The effect of biological activity

Active Publication Date: 2009-12-16
BEIJING NATON TECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reaction time of traditional alkali heat treatment usually requires 24-48h, which takes a long time, and the controllability of the substrate morphology is not high, and the improvement of biological properties is also limited.

Method used

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  • Surface treatment method for improving biological property of medical metallic titanium
  • Surface treatment method for improving biological property of medical metallic titanium
  • Surface treatment method for improving biological property of medical metallic titanium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) The base material is a 10mm×10mm×2mm pure titanium plate, the surface is polished with water-grinding paper, and then treated in an acid etching solution containing 10% (v / v) nitric acid and 1% (v / v) hydrofluoric acid Rinse for about 1 min, then ultrasonically clean with acetone, ethanol, and pure water in sequence, and dry for later use. Place the sample in a high-pressure reactor filled with 10mol / L NaOH solution, react at 100°C for 6 hours, take it out, and wash it with pure water. The obtained sample looks like figure 1 d and figure 2 shown. The obtained sample was washed with pure water, dried at room temperature, put into a box-type resistance furnace and calcined at 450°C for 2h under an unprotected atmosphere, with a heating rate of 5°C / min, and its Raman spectrum was as follows: Figure 5 shown in e. It can be seen from the analysis that the surface component is anatase TiO 2 film layer.

[0022] (2) Soak the prepared sample in SBF solution, the temp...

Embodiment 2～10

[0023] Examples 2-10: According to the same method as Example 1, change the concentration of NaOH used, the temperature and time of alkali treatment, and obtain film layer samples with different nanometer surface structures. The specific parameters are shown in Table 1. For all The prepared film layer samples were subjected to simulated body fluid immersion experiments, and the surface component was anatase TiO 2 Or samples with nanotube structure on the surface can induce the formation of apatite, showing good biological activity. The results are as follows Figure 6-8 .

[0024] Table 1

[0025]

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Abstract

The invention discloses a surface treatment method for improving biological property of medical metallic titanium, and relates to a new method for controllably constructing a titanium dioxide film layer with a specific nano-micro ordered structure and greatly improving biocompatibility and bioactivity of a hard tissue material through alkali thermal treatment for the surface of medical metallic titanium. The invention provides the surface treatment method for improving the biological property of the medical metallic titanium. After the surface of a titanium metal substrate is pretreated, the titanium metal substrate is subjected to alkali treatment, and then a nano-micro ordered sodium titanate film layer can be obtained on the surface of the titanium metal substrate, wherein the alkali treatment solution is NaOH solution; and the obtained titanium metal substrate with the nano-micro ordered sodium titanate film layer on the surface is calcined to obtain an anatase type TiO2 film layer with a specific structure.

Description

technical field [0001] The invention relates to a controllable construction of titanium dioxide (TiO 2 ) film layer, a new method for greatly improving the biocompatibility and bioactivity of hard tissue materials. Background technique [0002] When biomaterials are implanted into organisms, biological tissues must first directly interact with the material surface (D.A.Puleo, A.Nanci, Biomaterials, 1999, 20: 2311), and the biological properties of biomaterials largely depend on the physical properties of the material surface. chemical properties. Through the design of the surface of the material and the modification of its components and structure, the interaction between the material and the organism can be significantly regulated, thereby optimizing the biological performance of the material. In the clinical application of biomedical engineering, metal materials (including titanium, stainless steel, magnesium alloy, etc.) are often directly used as implants, such as nail...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26
Inventor 林昌健王卉孔莉莉林龙翔
Owner BEIJING NATON TECH GRP CO LTD
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