Magneto-strain displacement type needleless injector

Abstract

The invention discloses a magneto-strain displacement type needleless injector, which relates to a needleless injection device for injecting a preparation in particular a medicinal preparation into a human body or an animal body. The needleless injector comprises a cylinder body (1), wherein the upper section in the cylinder body (1) is provided with a micro-displacement system, the middle section is provided with a displacement amplification system, and the lower section is provided with a medicament cylinder (15). The needleless injector is characterized in that the micro-displacement system is designed according to a magneto-strain principle and consists of an electromagnetic coil (4) and a magnetic rod (6) with the function of magneto-strain. The magnetic rod (6) is arranged in the coil (4) and generates a magnetic field along the axial direction of the coil under the action of impressed current, and under the action of the magnetic field, the magnetic rod (6) generates radial magneto micro-strain which is amplified by a displacement amplifier to further drive a component connected the magnetic rod to generate macroscopic displacement, impact and accelerate a piston (15a) in the medicament cylinder (15) so as to extrude out the preparation instantly and carry out the injection type leading-in on the medicament. The magneto-strain displacement type needleless injector is suitable for performing micro-dose injection and macro-dose injection of other biological agents or chemical synthetic preparation of growth hormone, insulin, vaccine, hemoglobin, as well as peptides, proteins, oligonucleotides, nucleic acids and polysaccharides on the human body or the animal bodies, and is suitable for individuals who have no specialized knowledge about subcutaneous, intracutaneous and intramuscular injections.

Description

Technical field [0001] The invention relates to a needle-free injection device for injecting preparations, especially pharmaceutical preparations, into the body of a human body or an animal, especially a syringe capable of realizing subcutaneous, intradermal and intramuscular precise dose drug introduction under strict aseptic conditions. Background technique [0002] The traditional injection method causes local skin damage and bleeding, which not only causes significant pain, but also causes psychological fear in most patients (especially children), and also causes the risk of infection at the injection site. Long-term injection can also cause damage to the subcutaneous tissue, nerves, and capillaries. Injuries, and a large number of disposable syringes become medical waste that threatens environmental health after use. It is very inconvenient and expensive to dispose of these medical wastes. Therefore, the World Health Organization (WHO) has been calling for the developmen...

AI Technical Summary

Problems solved by technology

In contrast, the compressed gas method needs to be equipped with high-pressure gas chambers and corresponding air compression devices, which are bulky, expensive, energy-consuming and time-consuming, and extremely inconvenient to use; similar to rocket technology, the method of detonating fuel to generate shock waves can certainly provide Strong enough boosting force, but its potential danger and unstable factors are indeed worrying; using compression springs as the power system is simpler and easier than the above two methods, Equidyne Systems, Inc., a branch of Equidyne Corporation of the United States It took 8 years to successfully develop a spring-type needle-free syringe, and began to put its Injex series products on the market in July 2000

The syringe still has the following disadvantages: (1) Due to the need for a series of preparations such as compression, reset, alignment, and restraint of the spring body before and during use, as well as the need for special protection for subsequent safe triggering, the internal design of the corresponding power system It is very complicated, with many production processes, and the price is expensive ($250 / piece), which cannot be afforded by ordinary users; (2) The mechanical stability and fatigue of the spring system itself may cause mechanical failure during use, and the spring The power attenuates with the increase in the number of times of use and needs to be replaced regularly; (3) When the spring body hits the piston during injection, it produces a strong tremor and makes a loud noise, which brings an alternative sense of discomfort to the user; commercially available spring-type needle-free syringes Not only is it accompanied by loud noises during clinical use, but also visible erythema and even trauma are caused by the impact of the needle tube on the skin at the injection site

(4) It is still a contact injection method. In order to prevent cross-infection, it is still necessary to recommend a large number of disposable drug tubes

However, it is not difficult to find that the method itself still has some insurmountable or even fatal defects: (1) the piezoelectric ceramic itself has a small electrostrictive coefficient (100-600ppm), which determines that the technology is only suitable for micro-dose injection (45-140 nanoliters); (2) Due to the difficulty of sintering and polarization of PZT ceramics, and the difficulty of making large-scale products, the general finished products are thin slices, which requires several pieces or even dozens of pieces to be bonded together in the radial direction. To meet the requirements of displacement corresponding to the required power, the combination degree and rigidity of each part of the whole bonded body, and whether the effective accumulation of the micro-strain of each ceramic sheet can be guaranteed are directly related to the qualified rate and service life of the product. Technology is facing challenges; (3) The ceramic material is brittle and fragile, and may be damaged in the process of repeatedly slapping the piston; (4) In order to ensure sufficient strain in the ceramic body, the driving voltage often needs to be as high as several hundred volts Even thousands of volts, far higher than the safe voltage of the human body (36V), and under such a high voltage, the effective isolation and insulation design between the positive and negative poles inside the power system and the cylinder is very difficult, and the safety hazards cannot be ignored.

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