Analgesic antiphlogistic gel and preparation method thereof

Abstract

The invention relates to an analgesic antiphlogistic gel and a preparation method thereof. The gel comprises the following raw materials: wild celery, raw rhizoma arisaematis, raw radix aconiti feri, honeylocust, mirabilite, menthyl salicylate, borneol, carbomer 940, ethanol, polyethylene glycol 400 and nautisan. The preparation method comprises the following steps: breaking up the wild celery, the raw radix aconiti feri, the raw rhizoma arisaematis and the honeylocust, soaking and decocting the mixture with water, and performing filtration, concentration, cryoprecipitation and filtration on the decoction; taking glycerine and ethanol and proper amount of purified water, stirring the materials evenly and then adding the mirabilite into the mixture, stirring the mixture evenly to dissolve the mirabilite, adding the carbomer, and standing and swelling the mixture to prepare a gel base material; and adding a liquid medicament, the menthyl salicylate, the borneol, the polyethylene glycol 400 and the nautisan into the gel base material, adjusting the PH to between 5.3 and 6.7, stirring the mixture evenly, and filling the mixture to obtain the analgesic antiphlogistic gel. Because talc powder with the most dosage in auxiliary materials of the base material is removed, the concentration of the effective components carried by the auxiliary materials with the same volume is greatly improved, and the medicament dosage volume is reduced, thus the analgesic antiphlogistic gel not only reduces the preparation cost and the transportation cost, but also is convenient for patients to use.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an analgesic and anti-inflammatory gel and a preparation method thereof. Background technique [0002] Analgesic and anti-inflammatory ointment is a product for external use according to the Ministry of Standards WS3-B-2478-97, which has the effect of reducing swelling and relieving pain. The curative effect is relatively accurate, and there are few manufacturers. However, the ointment base uses talcum powder, caramel and glycerin, and the dosage form is relatively backward. Due to the use of a large amount of talc powder (accounting for about half of the weight of the paste), the finished product is prone to delamination after being placed, and caramel and glycerin float on it. , The talcum powder sinks to the bottom of the bottle. Although it can be used after stirring during use, it is inconvenient to use, and the layers do not meet the quality requiremen...

AI Technical Summary

Problems solved by technology

However, the ointment base uses talcum powder, caramel and glycerin, and the dosage form is relatively backward. Due to the use of a large amount of talc powder (accounting for about half of the weight of the paste), the finished product is prone to delamination after being placed, and caramel and glycerin float on it. , the talcum powder sinks to the bottom of the bottle, although it can be used after stirring during use, it is inconvenient to use, and the layering does not meet the quality requirements of ointment, and there is a risk of random inspection in the market

Many experiments have been carried out in the past, including prolonging the cooking time of caramel, increasing the fineness of talcum powder, prolonging the mixing time and adding thickeners, etc., but only a slight improvement can be achieved, and the problem of delamination cannot be completely solved. , difficult to fill and user to use