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Oral sustained release granules

A technology of drug delivery and granules, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of unfavorable mass industrial production, incomplete dissolution of drugs, and large one-time investment, etc. problems, to achieve the effects of easy control of production quality, strong drug activity, and high yield

Inactive Publication Date: 2010-01-13
南京大渊美容保健有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the case of increasing the amount of coating to delay the dissolution rate, there is a problem that the drug does not dissolve completely, which is the so-called dissolution upper limit.
This type of equipment is expensive, the process is complicated, and the operation requirements are high. Therefore, the rate of defective products is high, the one-time investment is large, and the technical requirements for workers are strict, which is not conducive to mass industrial production.

Method used

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  • Oral sustained release granules
  • Oral sustained release granules
  • Oral sustained release granules

Examples

Experimental program
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Effect test

Embodiment 1

[0024] The active ingredients are resveratrol, quercetin, anthocyanins and proanthocyanidins, accounting for 73.75% by weight; microcrystalline cellulose in the carrier is 20%, ethyl cellulose is 5%, and polyvinylpyrrolidone is 1.5% , and the sum of the three is 26.5%; the aqueous solution with alcohol is mixed uniformly with a high-speed shear mixer, sieved or extruded; dried and made into granules.

Embodiment 2

[0026] Get active ingredient resveratrol, quercetin 52.5%; In the carrier, ethyl cellulose is 36.7%, polyacrylic acid resin 10.1%, the sum of the two is 46.8%; 0.7% polyethylene glycol (PEG400) is dissolved in iso Propanol is mixed evenly with a high-speed shear mixer, sieved or extruded; dried and made into granules.

Embodiment 3

[0028] Any one or more of the active ingredients resveratrol, quercetin, anthocyanins, proanthocyanidins, dextran, flavonoids, tea polyphenols, and vitamins is 40%; the microcrystalline fiber in the carrier The element is 15%, the ethyl cellulose (EC) is 35%, the aqueous dispersion of ethyl cellulose (trade name Surelease) is 10%, and the aqueous solution is mixed with a high-speed shear mixer, sieved or extruded into Molded; made into granules after drying.

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Abstract

The invention relates to oral sustained release granules using microcrystalline cellulose and ethyl cellulose as a carrier to be combined with active compositions. The invention solves the problem that the prior granule coating type sustained release insoluble drug is too slow in releasing from a skeleton, the release of the drug is affected by pH values and digestive hydrolysis speed, coating needs to be processed by special coating equipment which is expensive, has complex process, high requirement of operation and high rate of products with bad quality and is unfavorable to mass industrial production, and the like. In the invention, the microcrystalline cellulose and ethyl cellulose are combined to form a carrier and are matched with active compositions; the microcrystalline cellulose can accelerate the speed of the drug dissolving in a human body, while the ethyl cellulose can sustain the speed the drug dissolved in the human body, so that the absorption of the drug is improved through the cooperation of the microcrystalline cellulose and ethyl cellulose, the bioavailability is improved, the speed of the drug releasing in the human body is controlled, and the active compositions are given full play in the human body.

Description

technical field [0001] The invention relates to a sustained-release granule, in particular to a granule for oral sustained-release administration which takes microcrystalline cellulose and ethyl cellulose as carriers and combines active ingredients. Background technique [0002] Before the invention of this method, there were many studies on sustained-release granules, and they were also practically applied to medicines and nutraceutical products. At present, an example of an existing preparation method for oral sustained-release granule preparations is a method of coating a drug-containing core material with a water-insoluble polymer, although this preparation has a high ability to control drug release and excellent moisture resistance, resistance Humidity, abrasion resistance and storage stability, etc., but the coating composed of only water-insoluble polymers usually requires a considerable amount to control the drug in the case of highly water-soluble drugs or particles...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K45/08A61K47/36A61K47/38
Inventor 刘爱国
Owner 南京大渊美容保健有限公司
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