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Method for preparing rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance and application of obtained freeze-drying substance

A technology of alkaloid salts and total alkaloids, which is used in freeze-drying delivery, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of difficulty in complete drying, poor water solubility, etc. High and good water solubility

Inactive Publication Date: 2010-01-13
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the summer without supercritical CO in the prior art 2 The total alkaloid extract has poor water solubility and is difficult to dry completely, so that there is no total alkaloid supercritical CO in summer 2 The extract is suitable for the application of various dosage forms. We have conducted in-depth research and prepared the freeze-dried product without total alkaloid salts in summer

Method used

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  • Method for preparing rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance and application of obtained freeze-drying substance
  • Method for preparing rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance and application of obtained freeze-drying substance
  • Method for preparing rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance and application of obtained freeze-drying substance

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Experimental program
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Effect test

preparation example Construction

[0022] No supercritical CO in summer 2 The preparation steps of the extract: take the dry tubers that are not available in summer, and crush them into 20-100 mesh medicinal powder; take a certain amount of medicinal powder, add an alkalizing agent, and mix until weakly alkaline; put the medicinal materials into the extraction kettle, and extract them at an extraction temperature of 40 ~75°C, when the temperature of the analysis tank I is 30-70 °C, and the temperature of the analysis tank II is 30-70 °C, the extraction pressure is 30-50 MPa, and a certain concentration of ethanol is continuously added as an entrainer during the extraction process; when the extraction is 2-3 hours Finally, the extraction was stopped, and the total alkaloid extract was obtained from the analysis kettle I as a sample for further research.

[0023] No supercritical CO in summer 2 The specific steps for extracting the lyophilized product are as follows: take the above-mentioned obtained summer with...

Embodiment 1

[0026] Take Different Summer No Supercritical CO 2 Each 20mL solution of the total alkaloid extract was placed in a round-bottomed flask and spin-dried. Add 80mL of acid solutions of different concentrations and types, ultrasonically dissolve, let stand overnight, and filter with a microporous membrane after centrifugation. The initial filtrate was discarded, and the continued filtrate was used as the test solution. Take each 0.2mL of each test solution in a 10mL volumetric flask, and use the mobile phase to constant volume as the sample solution. Take 1 mL of each summer-free extract solution in a 25 mL measuring bottle, evaporate to dryness, add 1 mL of 1% HCL solution to dissolve, and dilute to volume with mobile phase as a control sample solution. Take 20 μL of each sample solution and control sample solution for injection. The content of alkaloids was determined by high performance liquid chromatography, and the recovery rate was used to evaluate the treatment effect. ...

Embodiment 2

[0035] Take different batches of summer without supercritical CO 2 To the total alkaloid extract solution, add 200 mL of different acid solutions as shown in Table 3, ultrasonically dissolve, let stand overnight, and filter with a microporous membrane. The initial filtrate was discarded, and the continued filtrate was used as the test solution. Take each 0.5mL of each test solution in a 25mL volumetric flask, and use the mobile phase to constant volume as the sample solution. Take each summer without supercritical CO 2 Put 1mL of the extract solution in a 25mL measuring bottle, evaporate to dryness, add 1mL of 1% HCL solution to dissolve, and use the mobile phase to constant volume as the control sample solution. Take 20 μL of each sample solution and control sample solution for injection. The alkaloid content was determined by high performance liquid chromatography, and the recovery rate was used to evaluate the treatment effect of different acids. The results are shown i...

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Abstract

The invention discloses a method for preparing a rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance, which comprises the following steps: a) using supercritical CO2 total alkaloids extract of rhizoma corydalis decumbeutis as a raw material, adding acid water solution into the raw material to dissolve the raw material so as to obtain acid water solution of rhizoma corydalis decumbeutis total alkaloids; and b) filtering the acid water solution of the rhizoma corydalis decumbeutis total alkaloids obtained in the step a) or filtering the acid water solution after centrifugating, and freeze-drying the clarified solution to obtain the rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance. The obtained rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance has the characteristics of good water solubility, easy operation, high effective component content and the like, and is in powder shape. The invention also discloses application of the rhizoma corydalis decumbeutis total alkaloids acid salt freeze-drying substance prepared by the method in preparing tablets, capsules, grains, powder and injection.

Description

technical field [0001] The invention relates to the field of traditional Chinese herbal medicines, in particular to a method for preparing a freeze-dried product of summer free of total alkaloid salts and an application of the freeze-dried product of summer free of total alkaloid salts prepared by the method in preparing pharmaceutical preparations. Background technique [0002] Summer Wu is the dry tuber or whole plant of Corydalis decumbens (Thunb.) Pers., a plant of the genus Corydalis of the family Papaveraceae, which is widely distributed in Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hunan and other provinces. It is a commonly used Chinese herbal medicine in my country. , has the effects of promoting blood circulation, dredging collaterals, promoting qi, and relieving pain. It is mainly used to treat stroke and hemiplegia caused by high blood pressure and cerebrovascular diseases, and has a good effect on rheumatoid arthritis, sciatica, and sequelae of polio. Its...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/19A61K9/16A61K9/20A61K9/48A61P9/10A61P9/12A61P25/00A61P29/00
Inventor 杨义芳黄春跃蒋爱芳
Owner SHANGHAI INST OF PHARMA IND
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