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Novel torasemide oral medicine composition

A technology of torasemide and its composition, which is applied in the field of new torasemide oral pharmaceutical composition, can solve the problems of patients with large oral irritation, and achieve the effects of overcoming the irritating taste, mature technology, and simple operation

Active Publication Date: 2010-01-27
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1771945A discloses torasemide dispersible tablet and its preparation method and application. It is prepared by adopting this scheme technology, but there is a technical defect that oral administration brings greater oral irritation to patients.

Method used

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  • Novel torasemide oral medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of torasemide taste-masking composition

[0023] Torsemide 10g

[0024] Mannitol 40g

[0025] Gelatin 50g

[0026] Aspartame 0.1g

[0027] Makes 1000 pieces

[0028] Preparation process: Pass the gelatin, mannitol and aspartame through a 60-mesh sieve respectively, add appropriate amount of distilled water to the gelatin to dissolve the gelatin, add torasemide, mannitol and aspartame respectively under stirring, and place at 70-80 Stir in a water bath at ℃, evaporate to dryness, pulverize, pass through a 50-mesh sieve, and set aside;

[0029] (2) Preparation of torasemide orally disintegrating tablets

[0030] Torsemide masking composition 100.1g

[0031] Microcrystalline Cellulose 70g

[0032] Croscarmellose Sodium 14g

[0033] Mannitol 13.5g

[0034] Orange essence 0.5g

[0035] Magnesium Stearate 4g

[0036] Makes 1000 pieces

[0037] Preparation process: according to the amount of the above-mentioned raw and auxiliary materials, double-ch...

Embodiment 2

[0039] (1) Preparation of torasemide taste-masking composition

[0040] Torsemide 10g

[0041] Mannitol 50g

[0042] Gelatin 30g

[0043] Aspartame 0.1g

[0044] Makes 1000 pieces

[0045] Preparation process: Pass the gelatin, mannitol and aspartame through a 60-mesh sieve respectively, add appropriate amount of distilled water to the gelatin to dissolve the gelatin, add torasemide, mannitol and aspartame respectively under stirring, and place at 70-80 Stir in a water bath at ℃, evaporate to dryness, pulverize, pass through a 50-mesh sieve, and set aside;

[0046] (2) Preparation of torasemide orally disintegrating tablets

[0047] Torsemide masking composition 90.1g

[0048] Microcrystalline Cellulose 63g

[0049] Croscarmellose Sodium 12.6g

[0050]Mannitol 12.2g

[0051] Orange essence 0.45g

[0052] Magnesium Stearate 3.6g

[0053] Makes 1000 pieces

[0054] Preparation process: according to the amount of the above-mentioned raw and auxiliary materials, double...

Embodiment 3

[0055] Embodiment 3 (comparative example)

[0056] Torsemide 10g

[0057] Mannitol 40g

[0058] Gelatin 50g

[0059] Aspartame 0.1g

[0060] Microcrystalline Cellulose 70g

[0061] Croscarmellose Sodium 14g

[0062] Mannitol 13.5g

[0063] Orange essence 0.5g

[0064] Magnesium Stearate 3.6g

[0065] Makes 1000 pieces

[0066] Preparation process: according to the amount of the above-mentioned raw and auxiliary materials, double-checked and weighed, mixed evenly, granulated with water, compressed into tablets, the hardness is 5-7kg, and it is ready.

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Abstract

The invention relates to a pharmaceutical composition containing a torasemide odor masking composition and a preparation method thereof. The invention is characterized in that flavoring agent in the torasemide odor masking composition is selected from gelatin, mannite and aspartame; and the pharmaceutical composition exists in the form of powder or grains, can lead to good preparation stability and covers the bitterness, has good mouth taste, and is fast to beak down and absorb and convenient to carry.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing torasemide taste-masking composition and a preparation method thereof. The torasemide is prepared into a taste-masking composition, and other auxiliary materials are added to prepare a torasemide dispersible tablet, so that the torasemide can be quickly dispersed in water, and the oral irritation of the torasemide is masked. Background technique [0002] Disturbance of water and electrolyte metabolism is a very common and important clinical problem. If it is not corrected in time, it will cause corresponding obstacles to the physiological functions of various organ systems in the whole body, especially the cardiovascular system and nervous system, and the substance metabolism of the body. Can cause death. Drugs that can affect the transport function of renal tubules have become important clinical tools for the treatment of water and electrolyte metabolism disorders. Diuretics are drugs ...

Claims

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Application Information

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IPC IPC(8): A61K31/44A61K47/42A61K47/16A61K47/10A61K9/20A61J3/10A61P7/10
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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