Direct implantation type microdialysis probe and preparation method thereof

A probe, a direct technology, applied in the field of biomedical living sampling, can solve the problems of tissue damage and other problems, achieve the effect of easy implantation, not easy to bend under force, and avoid clogging or leakage

A probe, a direct technology, applied in the field of biomedical living sampling, can solve the problems of tissue damage and other problems, achieve the effect of easy implantation, not easy to bend under force, and avoid clogging or leakage

CN101642380AInactive Publication Date: 2010-02-10EAST CHINA UNIV OF SCI & TECH
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  • Direct implantation type microdialysis probe and preparation method thereof

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Embodiment 1

[0032] The direct implantable microdialysis probe of the present invention is mainly composed of a hollow dialysis membrane 1, a tipped capillary 2, and an ordinary capillary 3; the hollow dialysis membrane 1 is a tubular polysulfone membrane, and the capillaries 2 and 3 are elastic quartz capillaries; wherein the capillary 2 The tip of the tip is fired into a pointed shape; the capillary 2 with the tip and the hollow dialysis membrane 1, and the hollow dialysis membrane 1 and the capillary 3 are glued firmly with epoxy resin glue 5; a silver wire 4 runs through it, making the adhesion convenient , and serve as a support and protection function, and can also prevent the middle channel from being blocked; when the probe is implanted into the target tissue, hold the capillary 2 and gently rotate it into the tissue, and after extending for a certain distance, the pointed tip 6 will pass through the tissue, making The hollow dialysis membrane 1 is completely embedded in the tissue;...

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Abstract

The invention relates to a direct implantation type microdialysis probe and a preparation method thereof. The probe comprises a hollow dialysis membrane and two different connecting pipes, wherein thetwo connecting pipes are respectively connected to both sides of the hollow dialysis membrane to be used as a liquid inlet pipe and a liquid outlet pipe, one end of one connecting pipe is burnt intoa pointed head so that the connecting pipe can conveniently penetrate into tissues, and connecting parts are well glued by gluewater; in the process of preparation, one metal wire penetrates through the dialysis membrane and the connecting pipes; when the probe is implanted, the dialysis membrane is supported by the metal wire and can not be bent, folded and broken; and after the probe is implanted, the metal wire is pulled out, the pointed head is nipped off, and perfusate can not be prevented from flowing. The invention has the advantage that the preparation process is simple; and when the probe is used, the thin pointed head penetrates into the tissues, the resistance force is low, and the dialysis membrane is not easily stressed to be bent and folded.

Description

【Technical field】 [0001] The invention relates to the technical field of living body sampling in biomedicine, in particular to the preparation and use method of a directly implanted microdialysis probe. 【Background technique】 [0002] Microdialysis technology is a new trace biochemical sampling and detection technology. The main principle is to use a semi-permeable membrane with a certain molecular weight cut-off to make a microdialysis probe, implant the probe into the target tissue, and the small molecules in the extracellular fluid will expand to the target tissue through the semi-permeable membrane driven by the concentration gradient. In the perfusate, after the effluent with a certain flow rate is collected, high-performance liquid chromatography, capillary electrophoresis and other analytical techniques are used to further measure the information of various substances in the effluent, so as to study the changes of substances in the tissue. [0003] As a living sampli...

Claims

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Application Information

Patent Timeline
10 Feb 2010
Publication
CN101642380A
IPC
A61B10/02
Inventors
杜一平; 方娟娟