Nimesulide liposome solid preparation and preparation method of drug composite thereof
A technology of nimesulide and solid preparations, which is applied in the field of medicine, can solve the problems of poor dissolution of active ingredients and low bioavailability, and achieve the effects of stable product quality, reduced drug toxicity, and reduced drug side effects
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Embodiment 1
[0037] The preparation of embodiment 1 nimesulide liposome
[0038] Prescription: Nimesulide 50g
[0039] Monolaurin 150g
[0040] Cholesterol 25g
[0041] Poloxamer 188 100g
[0042] Preparation Process
[0043] (1) 50g nimesulide, 150g monoglyceride laurate, 25g cholesterol and 100g poloxamer 188 were dissolved in 800ml dehydrated ethanol, mixed uniformly, decompressed and removed dehydrated alcohol on a rotary thin film evaporator, Prepare phospholipid film;
[0044](2) Add 800 ml of pH=5.5 phosphoric acid-disodium hydrogen phosphate buffer solution, shake, stir to make the phospholipid film fully hydrated, high-speed homogeneous emulsification, and obtain a liposome suspension;
[0045] (3) Freeze-drying the suspension to prepare nimesulide liposomes.
Embodiment 2
[0055] The preparation of embodiment 2 nimesulide liposome
[0056] Prescription: Nimesulide 100g
[0057] Monolaurin 1000g
[0058] Cholesterol 100g
[0059] Poloxamer 188 10g
[0060] Preparation Process
[0061] (1) Dissolve 100g nimesulide, 1000g monoglyceride laurate, 100g cholesterol and 10g poloxamer 188 in 2000ml dehydrated ethanol, mix well, remove dehydrated alcohol under reduced pressure on a rotary thin film evaporator, Prepare phospholipid film;
[0062] (2) Add 1000ml of acetic acid-sodium acetate buffer solution with pH=6.0, shake and stir to make the phospholipid film fully hydrated, homogeneously emulsify at a high speed, and obtain a liposome suspension;
[0063] (3) The suspension is spray-dried to prepare nimesulide liposomes.
Embodiment 3
[0073] The preparation of embodiment 3 nimesulide liposome
[0074] Prescription: Nimesulide 75g
[0075] Monolaurin 400g
[0076] Cholesterol 300g
[0077] Poloxamer 188 150g
[0078] Preparation Process
[0079] (1) 75g nimesulide, 400g monoglyceride laurate, 300g cholesterol and 150g poloxamer 188 were dissolved in 2000ml dehydrated ethanol, mixed uniformly, decompressed and removed dehydrated ethanol on a rotary thin film evaporator, Prepare phospholipid film;
[0080] (2) Add 2000ml of pH=6.5 citric acid-sodium citrate buffer solution, shake and stir to make the phospholipid film fully hydrated, and high-speed homogeneous emulsification to obtain a liposome suspension;
[0081] (3) Freeze-drying the suspension to prepare nimesulide liposomes.
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