Marine oligosaccharide compound with type II diabetes resisting activity
A uronic acid oligosaccharide and marine technology, which is applied in the direction of sugar compounds with non-glycosyl groups, organic active ingredients, sugar derivatives, etc., can solve the problems of poor oral absorption, unclear action targets, and low bioavailability , to achieve the effect of high chromium binding rate, good oral absorption and low molecular weight
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Embodiment 1
[0013] Weigh 10g polymannuronic acid (weight average molecular weight is 7350 Daltons) and dissolve in 500ml pure water, adjust pH=10 with sodium hydroxide solution, add 2mol / L sodium hydroxide and 2mol / L chromium chloride solution, when green flocculent precipitates appear in the solution, stop adding sodium hydroxide and chromium chloride, and continue to keep warm for 1 hour. Take out the reaction solution, filter, concentrate the filtrate to 200mL, add 3 times the volume of 95% ethanol, precipitate, stand still, collect the precipitate, dehydrate with absolute ethanol, and dry under reduced pressure at 45°C to obtain a chromium content of about 15%. % Chromium polymannuronate complex.
Embodiment 2
[0015] Weigh 10g of polymannuronic acid (weight-average molecular weight: 5200 Daltons) and dissolve it in 500ml of pure water, adjust pH=8 with sodium carbonate solution, add 2mol / L sodium carbonate and 2mol / L sodium carbonate dropwise in a water bath at 70°C L chromium acetate solution 1mL, heat preservation reaction 1h. Take out the reaction solution, filter, concentrate the filtrate to 200mL, add 3 times the volume of acetone, precipitate, stand still, collect the precipitate, dehydrate with acetone, and dry under reduced pressure at 45°C to obtain polymannose with a chromium content of about 1%. Chromium uronic acid complex.
Embodiment 3
[0017] Weigh 10g of polymannuronic acid (weight-average molecular weight: 1500 Daltons) and dissolve it in 500ml of pure water, adjust the pH to 5, add 2mol / L sodium hydroxide and 2mol / L chromium nitrate dropwise in a water bath at 60°C Solution 5mL, insulation reaction 1h. Take out the reaction solution, filter, concentrate the filtrate to 200mL, add 4 times the volume of acetone, precipitate, stand still, collect the precipitate, dehydrate with acetone, and dry under reduced pressure at 45°C to obtain polymannose with a chromium content of about 5%. Chromium uronic acid complex.
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