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Method for preparing soft capsules by extracting alpha-linolenic acid from paeonia peony seeds

A technology of purple spot peony and soft capsules, which is applied in capsule delivery, fatty acid preparation/refining, pharmaceutical formulations, etc., can solve the problems of small production volume, narrow distribution range, and expensive price of linolenic acid products, and achieve high product added value, The effect of expanding planting area and low raw material cost

Inactive Publication Date: 2010-02-24
GANSU ZHONGCHUAN PEONY RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main production materials of linolenic acid products on the market are linseed or perilla seed. However, due to the low yield and narrow distribution range of these two crops, the production volume of linolenic acid products is small, the cost is high, and the price is expensive, which is difficult to meet the huge demand. market demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Extraction of seed oil: select 100kg of mature purple spot peony seeds, fry and squeeze, and place the squeezed oil to settle for 24 hours, then filter to obtain 26kg of pressed oil;

[0018] 2. Ethyl esterification: add 13L of absolute ethanol and 0.26kg of sodium ethoxide to the peony seed oil and mix, fill the mixture with nitrogen gas at 60°C, stir and reflux for 24 hours, recover ethanol, and obtain a mixture of fatty acid esters;

[0019] 3. Fatty acid ethyl ester purification: adjust the pH value of the fatty acid ester obtained in the previous step with 10% HCl solution to be weakly acidic, then wash 3 times with saturated brine equivalent to the fatty acid ester, add 30L petroleum ether to extract and separate the organic phase, washed with deionized water until Cl-free - , dried with anhydrous sodium sulfate to obtain fatty acid ethyl ester 16.3kg;

[0020] 4. Urea clathrate: Take 10kg of fatty acid, 20kg of urea, and 200L of ethanol obtained in the previo...

Embodiment 2

[0026] 1. Extraction of seed oil: select 60kg of mature purple spot peony seeds, fry and squeeze, and place the squeezed oil to settle for 40 hours, then filter to obtain 14.8kg of pressed oil;

[0027] 2. Ethyl esterification: add 7.4L of absolute ethanol and 0.15kg of sodium ethoxide to peony seed oil and mix, fill the mixture with nitrogen gas at 60°C, stir and reflux for 24 hours, recover ethanol, and obtain a mixture of fatty acid esters;

[0028] 3. Fatty acid ethyl ester purification: adjust the pH value of the fatty acid ester obtained in the previous step with 10% HCl solution to be weakly acidic, then wash 3 times with saturated brine equivalent to the fatty acid ester, add 15L petroleum ether to extract and separate the organic phase, washed with deionized water until Cl-free - , dried with anhydrous sodium sulfate to obtain 8.7kg of fatty acid ethyl ester;

[0029] 4. Urea clathrate: Take 5kg from the fatty acid ethyl ester obtained in the previous step, take anot...

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Abstract

The invention relates to a method for preparing soft capsules by extracting alpha-linolenic acid from paeonia peony seeds. The method comprises the following steps: extracting seed oil; carrying out ethyl esterification; purifying fatty acid ethyl ester; including by urea; separating fatty acid ester; twice including; adding antioxidants; preparing the soft capsules, and the like. The alpha-linolenic acid is extracted from the peony seeds by twice urea inclusion; the product reaches a content of the alpha-linolenic acid over 70 percent and a total content of unsaturated fatty acid over 95 percent; and alpha-linolenic acid urea inclusion adopts non-toxic alcohol as solvent to ensure the safety of the product. The peony seeds is used for producing a linolenic healthcare product with high extraction rate, low raw material cost and high product added value, thereby not only increasing the income of peony planters and having important meanings for expanding the plantation area of a valuablevariety, i.e. paeonia peonies, adjusting the agricultural industrial structure and promoting the economic development of production places.

Description

technical field [0001] The invention relates to the technical field of deep processing of peony products and the development of health care products, especially the extraction and utilization technology of peony seeds, specifically a method for extracting α-linolenic acid from peony seeds to make soft capsules. Background technique [0002] Gansu is an important birthplace of Chinese peony. Gansu purple spot peony is the second largest variety group of Chinese peony. It is widely cultivated in various parts of Gansu for its characteristics of cold resistance and drought tolerance, tall plants, and strong knot strength. For a long time, the peonies cultivated in various places are mainly for ornamental purposes and sales of seedlings. However, the development and utilization of deep-processed products of peony has lagged behind seriously, the added value of production is very low, and no industrial chain has been formed. In particular, only a small amount of peony seeds are us...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/202A61K47/22A61P37/04A61P35/00A61P9/10A61P37/08A61P29/00A61P39/06A61P25/24A61P25/28A61P25/18A61P19/04A61P3/10A61P11/06A61P13/12A61P11/00A61P27/02A61P3/06A61P9/12C11B1/06C11C3/04C11C1/04
Inventor 赵潜龙王艳君邱如文郑爱霞赵剑锋崔欣祥乔萍
Owner GANSU ZHONGCHUAN PEONY RES INST
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