Gellan gum composition, preparation method thereof and application thereof

A technology of gellan gum and composition, which is applied in the fields of pharmaceutical formulations, medical preparations of non-active ingredients, medical science, etc., can solve the problems of easy damage to drug activity, long processing time, cumbersome operation, etc., and achieve convenient preparation, The effect of high operation cost and reduced operation difficulty

Inactive Publication Date: 2010-03-03
INST OF BIOPHARM OF SHANDONG PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned method for preparing a mixture of gel and water-soluble drug is cumberso

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Accurately weigh 40 mg of high acetylation gellan gum and 10 mg of low acetylation gellan gum, and mix them. Add 80 mL of deionized water to the mixture, heat in a boiling water bath and stir to completely hydrate into a solution state, then add deionized water and set the volume to 100 mL, divide into ampoules of 1 mL per branch, and sterilize with moist heat. Subjects who need facial fine wrinkle filling cosmetics, after blood and urine routine, electrocardiogram, liver and kidney function, HIV, and HbsAg indicators are normal, then undergo a skin test (same method as the penicillin skin test) without immune response. A 30-gauge needle is used for multi-point inclined-plane injection, and the gellan gum composition solution is injected into the dermis of the planned injection site at the corner of the subject's eye. After surgery, be careful not to pinch the injection site. Ca in the interstitial space at the injection site of the subject 2+ , Mg 2+ 、Na + and K +...

Embodiment 2

[0051] Example 2: Preparation of 0.06% gellan gum composition and its application for skin dent filling

[0052] Accurately weigh 54 mg of high acetylation gellan gum and 6 mg of low acetylation gellan gum, and mix them. Add 80 mL of deionized water to the mixture, heat in a boiling water bath and stir to completely hydrate into a solution state. Add CaCl to the gellan gum solution 2 0.4440g, stirred until completely dissolved, supplemented with deionized water to make up to 100mL, divided into ampoules by 1mL / branch, and sterilized by moist heat. Subjects who need facial skin depression filling are ready to receive gellan gum filling skin test after blood and urine routine, electrocardiogram, liver and kidney function, HIV, and HbsAg indicators are normal. Heat 1 mL / branch of gellan gum gel ampoule on a boiling water bath to liquefy the gel into a solution state, and quickly transfer it to a 45°C constant temperature drying operation cabinet. Use a 1mL syringe to draw gell...

Embodiment 3

[0053] Embodiment 3: 0.05% gellan gum composition for drug release

[0054] Accurately weigh 40 mg of high acetylation gellan gum and 10 mg of low acetylation gellan gum, and mix them. Add 50 mL of deionized water to the mixture, heat and stir in a boiling water bath to completely hydrate into a solution state, then transfer to a 45°C water bath to keep warm, and the following operations are all carried out at this temperature. Add to the gellan gum solution under sterilization conditions: antineoplastic drugs such as paclitaxel (25.00mL, 5mg / mL); steroidal anti-inflammatory drug solutions such as dexamethasone (5.00mL, 25mg / mL), etc. . Then, add 0.2340 g of NaCl to the mixed solution of gellan gum and drug, stir until completely dissolved, add deionized water to make the volume to 100 mL, and pack in 25 mL per branch. Upon cooling to room temperature, a gel containing evenly distributed drug is formed and can be sterilized by moist heat if necessary.

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Abstract

The invention discloses a gellan gum composition, which is mainly prepared from a gellan gum with a high acetylation degree and/or a gellan gum with a low acetylation degree or a derivative thereof. The invention also provides a preparation method of the composition and a use method of the composition. The composition has a large amount of application serving as an injection device and/or implanted device and a medicament releasing system. The composition has the advantages that: by controlling the gelling temperature and gel elasticity of the composition, the composition can be injected in asolution state when injected to beatify so as to reduce the injection pushing resistance, and then is changed into a cohesive gel to play the corresponding role; and when prepared into a water-solublemedicinal gel, the composition can be easily and uniformly mixed by stirring in a solution state to form a gel, thereby reducing the difficulty of uniformly mixing the gel.

Description

technical field [0001] The present invention relates to a gellan gum composition, its preparation method and its use: for example, as injection and / or implantation soft tissue filler in cosmetic or medical treatment, and as a drug release system for drug molecules and other therapeutic agents. Background technique [0002] The pursuit of human perfection has never stopped, and injection beauty technology is also constantly improving. [0003] Injection of botulinum toxin is currently the best way to remove dynamic wrinkles. Botulinum toxin is a highly neurotoxic protein that blocks "signaling" between nerves and muscles, allowing overly contracted muscles to relax and stretch. After diluting it, it can be used to remove early and less obvious wrinkles on the human face, such as general crow's feet, forehead lines, and neck wrinkles. The wrinkle removal effect produced by one injection can last for 4 to 6 months. To achieve long-term effects, it usually takes one 3-4 inject...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61K47/36
Inventor 郭学平朱希强凌沛学陈勉李海军苏移山张晓元颜震候重文
Owner INST OF BIOPHARM OF SHANDONG PROVINCE
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