The invention discloses a locking multi-mode lever-type variable valve driving system, belonging to the field of engine valve driving. The variable valve driving system mainly comprises a cam shaft, a mode input mechanism, a mode output mechanism, a mode switching mechanism, a valve regulating lever, a valve control mechanism and the like. By using the mode switching mechanism, the switching among multiple modes, including a two-stroke driving mode, a four-stroke driving mode, a two-stroke braking mode, a four-stroke braking mode and the like, of an engine is realized, further, by matching with the valve control mechanism for use, the optimum ventilation under different working conditions of the engine is finally realized, and the aims of comprehensively improving the engine dynamic property, fuel economy, emission performance and braking security are achieved. The invention is proposed by aiming at practical application, the reliability is high, the structure is compact, the requirements of a system on all the mechanisms are reduced, relatively mature technologies are adopted by all the mechanisms, the practical potential of the system in a short time is high, and the application prospect is good.