Composition preparation of ginkgo biloba extract and dipyridamole and preparation method thereof

Abstract

The invention discloses a composition preparation of ginkgo biloba extract and dipyridamole and preparation method thereof, which is a traditional Chinese medicine injection preparation prepared by combining 20 to 100 parts of ginkgo biloba extract and 2 to 10 parts of dipyridamole. Wherein the ginkgo biloba extract is obtained by proceeding respective alcohol extraction and water extraction to ginkgo biloba medicinal material, the extracting solution is then concentrated, micro-filtration by inorganic ceramic film, refining by polyamide resin and then being made by organic film ultrafiltration. Comparing with the prior art, the invention adopts a method of membrane separation technology combined with resin refining treatment to proceed purifying, separating and condensation to the extract, active ingredient is enriched, physical method is used to replace conventional chemical method can maintain characteristics of traditional Chinese medicine compound preparation better, which reducesadverse effects of drugs and improves curative effect, and thereby quality of the product is improved and assured.

Description

Technical field: [0001] The invention relates to a composition preparation of ginkgo biloba extract and dipyridamole and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Traditional Chinese medicine injection preparations are sterilized preparations made from Chinese medicinal materials through extraction, separation, refining and other steps. It has changed the traditional way of drug administration of traditional Chinese medicine, and has the advantages of rapid drug effect, high bioavailability, and more accurate dosage. It has played a good role in the treatment of acute, severe and difficult diseases by traditional Chinese medicine. However, with the increasing clinical application, the incidents of adverse drug reactions caused by traditional Chinese medicine injections have occurred frequently, which has attracted the attention of the majority of medical workers. The main reasons ...

AI Technical Summary

Problems solved by technology

There are many kinds of extraction processes for the total flavonoid glycosides and total terpene lactones in Ginkgo biloba leaves. Generally, organic solvent extraction, resin or activated carbon adsorption, precipitation and separation are often used. Recently, supercritical CO2 extraction has appeared. However, the type and amount of organic solvents introduced by the latter two methods are more complicated, and at the same time, residual solvents are likely to cause allergies and side effects, which are extremely unfavorable for large-scale production and marketing.

[0004] The patent document with the application number 200410039123.2 discloses a ginkgo damole powder injection for injection and its preparation method. The preparation method of the ginkgo leaf extract is the initial extraction by alcohol extraction and water precipitation method, and then the macroporous resin is purified to obtain the total flavonoids of ginkgo biloba. CO 2 The total ginkgo lactones were obtained by supercritical extraction, and the active ingredients obtained by this method were improved, but the operation was cumbersome, and the temperature, pressure, flow rate and solvent selection in the purification process greatly affected the acquisition of active ingredients; At the same time, due to the complex components of the extract of Chinese herbal medicines, which contain a large amount of impurities in addition to the active ingredients, the structures of each component are different, and the molecular sizes are also different.