Method for analyzing high performance liquid chromatography of methanesulfonic amine ginkgolide B

Abstract

The invention relates to a method for analyzing a high performance liquid chromatography of methanesulfonic amine ginkgolide B, comprising the following steps: using chromatographic columns with different polarities, adopting one or more organic solvents and aqueous-phase mixing liquid as a flowing phase, and under the detection conditions that the column temperature is 10-50 DEG C, the flow velocity of the flowing phase is 0.1-10ml / min, and the detection wavelength is 190-400nm, identifying bulk drugs and preparations of the methanesulfonic amine ginkgolide B, detecting relative matters and measuring the content by adopting an ultraviolet detector or a diode array detector so as to control the quality of the methanesulfonic amine ginkgolide B.

Description

technical field

[0001] The invention relates to a high-performance liquid chromatography analysis method for amine ginkgolide mesylate B, which has good effect on the quality control of the raw material drug of the compound and its preparation, and its technical field belongs to the analysis method of medicine. Background technique

[0002] Mesylate amine ginkgolide B is a mesylate salt, and its core part is an amino-containing molecule obtained after derivation and modification of ginkgolide B. Ginkgolide B (Ginkgolide B, GB) is a hexacyclic cage structure diterpenoid extracted from Ginkgo biloba, and it is the strongest platelet activating factor (PAF) antagonist found so far. Amino ginkgolide mesylate B is a semi-synthetic innovative compound with the molecular formula C 24 h 33 o 10 N·CH 4 o 3 S, the molecular weight is 591.63. The molecular structure is as follows:

[0003]

[0004] Amino ginkgolide mesylate B is a PAF-specific antagonist, which can inhibit th...

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