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Emamectin benzoate solid lipid nanoparticle and preparation method and application thereof in pesticide formulation

A nanotechnology of emamectin and solid lipid, which is applied to the nano-preparation of biopesticides and its preparation process and application field, and can solve the severe decomposition and preparation process of the active ingredient emamectin benzoate Complexity, decreased drug efficacy and other problems, to achieve the effect of reducing UV photolysis, improving absorption rate, and reducing drug dosage

Inactive Publication Date: 2010-04-14
SHENZHEN NOPOSION AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, tests have shown that the active ingredient emamectin benzoate is severely decomposed in the cold and hot storage experiments in the preparations of the above compositions, and it is easy to photolyze during use, and the drug effect declines.
In order to solve this problem, the publication number is that the patent application of CN1663379A discloses the method that adopts in-situ polymerization to prepare emamectin benzoate microcapsules, although emamectin benzoate is not easy to be Air, sunlight and rain damage or loss can prolong the validity period of the drug, but its preparation process is complicated and can only be used to prepare suspensions

Method used

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  • Emamectin benzoate solid lipid nanoparticle and preparation method and application thereof in pesticide formulation
  • Emamectin benzoate solid lipid nanoparticle and preparation method and application thereof in pesticide formulation
  • Emamectin benzoate solid lipid nanoparticle and preparation method and application thereof in pesticide formulation

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Effect test

Embodiment 1

[0020] Embodiment 1: 4% solid lipid nano emamectin benzoate mother powder

[0021] The content of emamectin benzoate is 40 g / kg

[0022] Capric acid content is 785 g / kg

[0023] Polyvinyl alcohol content of 165 g / kg

[0024] 41.5 grams of 97% emamectin benzoate former drug and 785 grams of capric acid are dissolved in 100 grams of isopropanol, then mixed with 2200 grams of 7.5% polyvinyl alcohol aqueous solution, and the mixed solution is mixed by stirring Uniformly emulsified, then micronized by ultrasonic waves, stirred for 2 hours, and finally freeze-dried to obtain 4% solid lipid nanometer emamectin benzoate mother powder.

Embodiment 2

[0025] Embodiment 2: 8% solid lipid nano emamectin benzoate mother powder

[0026] The content of emamectin benzoate is 80 g / kg

[0027] The content of lauric acid is 760 g / kg

[0028] Polyvinyl alcohol content of 160 g / kg

[0029] Dissolve 82.5 grams of 97% emamectin benzoate technical substance and 760 grams of lauric acid in 200 grams of isopropanol, then mix with 2000 grams of 8% polyvinyl alcohol aqueous solution, and mix by high shear The solution was mixed evenly until emulsified, then micronized by ultrasonic waves, stirred for 3.5 hours, and then vacuum-dried to obtain 8% solid lipid nanometer emamectin benzoate mother powder.

Embodiment 3

[0030] Embodiment 3: 12% solid lipid nano emamectin benzoate mother powder

[0031] The content of emamectin benzoate is 120 g / kg

[0032] The content of palmitic acid is 700 g / kg

[0033] Polyvinyl alcohol content of 180 g / kg

[0034] 124 grams of 97% emamectin benzoate former drug and 700 grams of palmitic acid are dissolved in 300 grams of isopropanol, then mixed with 2000 grams of 9% polyvinyl alcohol aqueous solution, and the mixed solution is made by shaking Mix evenly until emulsified, then micronize with ultrasonic waves, stir for 5 hours, and then spray dry to obtain 12% solid lipid nano emamectin benzoate mother powder.

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Abstract

The invention discloses an emamectin benzoate solid lipid nanoparticle and a preparation method for a water dispersible granule, a suspension concentrate and wettable powder of the composition of the emamectin benzoate solid lipid nanoparticle with lufenuron, indoxacarb, pleocidin, chlorfenapyr and chlorantraniliprole. Compared with the composition preparation which is prepared by directly adopting the emamectin benzoate raw pesticide as raw material, the emamectin benzoate solid lipid nanoparticle has the advantages of improving the chemical stability of hot and cold storage, reducing the photolysis rate, prolonging efficacy time, reducing dosage, and significantly improving insecticidal effect.

Description

technical field [0001] The invention relates to the field of pesticide preparations, in particular to nano-preparations of biological pesticides and their preparation process and application. Background technique [0002] Emamectin benzoate (emamectin benzoate) is a new type of high-efficiency semi-organic salt obtained by structural modification of avermectin B1, which is a fermented product of soil actinomyces (Streptomyces avermitilis MA-4680), as a parent compound through Wilkinson reaction. Synthetic macrolide insecticidal antibiotic whose most sensitive target in insects is stimulation of neurotransmitters such as glutamine GABA-inhibitory chloride channels leading to cellular function by shifting high-affinity binding sites Loss and muscle paralysis, disturbed nerve conduction, insects stop eating immediately after contact or feeding, irreversible paralysis and death occur. Although emamectin benzoate is unstable to ultraviolet light and easy to decompose under acidi...

Claims

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Application Information

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IPC IPC(8): A01N25/10A01N43/90A01N47/34A01N47/38A01N43/22A01N43/36A01N43/56A01P7/04
Inventor 袁伏中曹明章李琛王新军陈树茂孔建
Owner SHENZHEN NOPOSION AGROCHEM
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