Hydrophilic polymer of resveratrol conjugate and preparing method thereof

A hydrophilic polymer, resveratrol technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations with non-active ingredients, etc., and can solve problems such as side effects

Inactive Publication Date: 2010-04-21
天津市尖峰天然产物研究开发有限公司
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN12204860 discloses a method for dissolving resveratrol with ethanol and then inclusion with β-cyclodextrin or its derivatives to im

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydrophilic polymer of resveratrol conjugate and preparing method thereof
  • Hydrophilic polymer of resveratrol conjugate and preparing method thereof
  • Hydrophilic polymer of resveratrol conjugate and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of hydrophilic polymer-resveratrol conjugate, comprises the steps:

[0026] (1) Weigh 0.048g of sodium hydride, place it in a round bottom flask, and dissolve it with a small amount of dimethylformamide (DMF); weigh 5.0g of monomethoxy polyethylene glycol 5000 (mPEG5000), dissolve it in about 100ml ( DMF), after dissolving, drop it into a round-bottomed flask with a dropping funnel; add 0.1 g of succinic anhydride, and react for 4 hours at 65° C., the product is a mixture of monomethoxypolyethylene glycol containing a carboxyl group at one end;

[0027] (2) Draw 1ml of thionyl chloride with a pipette, add it to the solution after step (1), react at room temperature for 4 hours, and react the carboxyl group in the molecule to generate acid chloride;

[0028] (3) Weigh 0.048g of sodium hydride, add it to the solution after the reaction in step (2), and dissolve it; add 0.076g of resveratrol, room temperature, dark, nitrogen, magnetic stirring reacti...

Embodiment 2

[0030] The preparation method of hydrophilic polymer-resveratrol conjugate, comprises the steps:

[0031] (1) Dissolve monomethoxypolyethylene glycol with a molecular weight of 1000 in an appropriate amount of dimethylformamide, add sodium hydride dissolved in a small amount of dimethylformamide, add succinic anhydride, and react at 60°C 4h, making monomethoxypolyethylene glycol with a carboxyl group at one end, the weight ratio of monomethoxypolyethylene glycol with a molecular weight of 1000 to the sodium hydride and succinic anhydride is 250:18:25;

[0032] (2) adding thionyl chloride to the monomethoxypolyethylene glycol solution obtained in step (1) with a carboxyl group at one end in a ratio of 1000:59 by weight, so that the carboxyl group in the molecule reacts to generate acid chloride;

[0033] (3) Mix the acid-chlorinated monomethoxypolyethylene glycol solution obtained in step (2) with resveratrol in a ratio of 750:57 by weight, add a small amount of sodium hydride ...

Embodiment 3

[0035] The preparation method of hydrophilic polymer-resveratrol conjugate, comprises the steps:

[0036] (1) Dissolve monomethoxypolyethylene glycol with a molecular weight of 8000 in an appropriate amount of dimethylformamide, add sodium hydride dissolved in a small amount of dimethylformamide, add succinic anhydride, and react at 70°C 3h, making monomethoxypolyethylene glycol with a carboxyl group at one end, the weight ratio of monomethoxypolyethylene glycol with a molecular weight of 8000 to the sodium hydride and succinic anhydride is 2000:18:25;

[0037] (2) adding thionyl chloride to the monomethoxypolyethylene glycol solution obtained in step (1) in a ratio of 4000:59 by weight, so that the carboxyl group in the molecule reacts to generate acid chloride;

[0038] (3) Mix the acid-chlorinated monomethoxypolyethylene glycol solution obtained in step (2) with resveratrol in a ratio of 8000:57 by weight, add a small amount of sodium hydride as a catalyst, keep at room tem...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a hydrophilic polymer of resveratrol conjugate and a preparing method thereof. The hydrophilic polymer of resveratrol conjugate has the following structure, wherein P represents monomethoxy-polyethylene glycol acyl, monomethoxy-polypropylene glycol acyl, polyglutamic acid acyl or poly aspartic acid acyl; n represents 1-3; D represents resveratrol monomer; and L represents connecting ester bond of -O-. In the invention, insoluble resveratrol is modified to soluble hydrophilic polymer of resveratrol conjugate, so that the application range of resveratrol is widened.

Description

technical field [0001] The invention relates to a hydrophilic polymer-resveratrol conjugate and a preparation method. Background technique [0002] Resveratrol (Resveratrol) is a natural non-flavonoid polyphenol compound mainly found in grapes, peanuts, veratrum, knotweed and other plants. It is a phytoalexin with a chemical name of 3,4',5-trihydroxy -trans-stilbene (3,4',5-trihydroxystilbene), white needle crystal, molecular formula C 14 h 12 o 3 , molecular weight 228.25, its molecular structure is as follows: [0003] [0004] Studies have found that resveratrol has a wide range of pharmacological activities, and has multiple functions such as anti-cancer, anti-oxidation, cardiovascular and cerebrovascular protection, inhibition of platelet aggregation, anti-inflammatory, antibacterial, and blood lipid regulation. At present, more and more scholars believe that resveratrol is the main functional factor that exerts cardiovascular protection in red wine, and that res...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08G65/48C08G69/48A61K47/48A61P35/00A61K47/60A61K47/64
Inventor 刘常金於洪建赵彦丽胡淳罡杨婷郑焕兰
Owner 天津市尖峰天然产物研究开发有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap