Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound articaine hydrochloride injection and preparation method thereof

A technology of articaine hydrochloride and injection, applied in the field of oral anesthetic compound articaine hydrochloride injection and preparation thereof, can solve problems such as pain, and achieve the effects of less side effects, lower content, and stable pH value

Active Publication Date: 2010-06-09
MAANSHAN BBCA PHARMA
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Currently, procaine and lidocaine injections are generally used for anesthesia during the operation of oral pulp disease, but the anesthesia mechanism only uses nerve block to play the role of anesthesia. The curative effect evaluation It shows that although anesthesia is effective, patients will feel pain during the operation and need patience to complete the operation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound articaine hydrochloride injection and preparation method thereof
  • Compound articaine hydrochloride injection and preparation method thereof
  • Compound articaine hydrochloride injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preliminary test was carried out to confirm the composition of the recipe, the process conditions and parameters, and no acetic acid-sodium acetate and disodium edetate were added during the experiment.

[0047] (1) Preparation volume: 10000ml;

[0048] (2) Equipment and instruments used: bottle washing machine, tunnel oven, stainless steel container and filter system for preparation, ampoule filling and sealing machine, steam sterilization cabinet, tray balance, electronic balance, etc.;

[0049] (3) Materials used: 400g of articaine hydrochloride, 110mg of epinephrine (including 10% additional amount) (note: in order to prevent the loss of epinephrine in the preparation process, the additional amount of 10% is generally added), 5g of sodium metabisulfite , sodium chloride 16g, medicinal charcoal 1g, water for injection about 10000ml.

[0050] (4) Preparation process:

[0051] ① Add 6000ml of water for injection into the preparation container, the temperature is arou...

Embodiment 2

[0064] On the basis of the preliminary test in Example 1, the prescription and process were improved, namely: adding acetic acid-sodium acetate and edetate disodium, and adjusting the order of feeding, while keeping the temperature of the preparation water at 25-30°C, Nitrogen protection during the process to reduce the amount of adrenaline added)

[0065] (1) Preparation volume: 10000ml;

[0066] (2) Equipment and instruments used: bottle washing machine, tunnel oven, stainless steel container and filter system for preparation, ampoule filling and sealing machine, steam sterilization cabinet, tray balance, electronic balance, etc.

[0067] (3) Materials used: articaine hydrochloride 400g; epinephrine 100mg; sodium metabisulfite 5g; sodium chloride 16g; edetate disodium 0.5g; acetic acid 10ml; sodium acetate 15g; to 10000ml.

[0068] (4) Preparation process:

[0069] ①Put 6000ml of water for injection into the preparation container, cool it until the temperature is around 2...

Embodiment 3

[0083] According to the method of Example 2, a scale-up test was carried out to further confirm the feasibility of the process.

[0084] (1) Preparation volume: 50000ml

[0085] (2) Equipment and instruments used: bottle washing machine, tunnel oven, preparation tank and filtration system, ampoule filling and sealing machine, steam sterilization cabinet, tray balance, electronic balance, etc.

[0086] (3) Materials used: articaine hydrochloride 2.0kg, epinephrine 500mg, sodium metabisulfite 25g, sodium chloride 80g, edetate disodium 2.5g, acetic acid 50ml, sodium acetate 75g, medicinal charcoal 5g, water for injection Add to 50000ml etc.

[0087] (4) Preparation process:

[0088] ①Add 35,000ml of water for injection into the preparation container, cool it down to about 25°C, and fill it with nitrogen;

[0089] ② Weigh the required materials respectively, first add sodium metabisulfite and disodium edetate into the cooled water for injection flushed with nitrogen, then add s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an oral narcotic of compound articaine hydrochloride injection and a preparation method thereof. The compound articaine hydrochloride injection provided by the invention has reasonable and strict recipe design, and the components of the compound articaine hydrochloride injection contain the special injection addition agents of an antioxidant, a metal complexing agent, a pH value buffering agent and the like, so that the injection is more stable; the preparation method of the compound articaine hydrochloride injection fully considers the instability of adrenalin, adopts various measures, keeps the stability of the pH value, also enhances the stability of the content of the articaine hydrochloride and the adrenalin, lowers the content of relevant substances, saves the cost and can ensure the long-time production of the compound articaine hydrochloride injection with stable quality.

Description

technical field [0001] The present invention relates to the technical field of anesthetics, in particular to a compound articaine hydrochloride injection for oral anesthetics and a preparation method thereof. Background technique [0002] Currently, procaine and lidocaine injections are generally used for anesthesia during the operation of oral pulp disease, but the anesthesia mechanism only uses nerve block to play the role of anesthesia. The curative effect evaluation It shows that although the anesthesia is effective, the patient will feel pain during the operation and needs patience to complete the operation. [0003] Compound Articaine Hydrochloride Injection, a new type of amide-type oral anesthetic, is a local anesthetic used in the surgical treatment of oral pulp disease in recent years. The commonly used specification is 1.7ml: Articaine Hydrochloride 68mg , 17 μg of epinephrine, the main components are 4% articaine hydrochloride and 1:100000 epinephrine, and it is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/381A61K31/137A61K9/08A61K47/04A61K47/12A61K47/18A61P23/02
Inventor 朱学娟汪洪湖
Owner MAANSHAN BBCA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com