Clear oral preparation with coenzyme Q10 and preparation method thereof
A technology for oral preparations and coenzymes, which is applied in the field of clear oral preparations containing coenzyme Q10 and its preparation, can solve the problems of poor stability, complicated preparation process and unsuitable storage for a long time, and achieves the effects of convenient storage, simple equipment and improved curative effect.
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[0026] Example 1
[0027] Coenzyme Q in this example 10 The components of the semi-clear oral preparation composition and their weight percentages are:
[0028] Coenzyme Q10: 4%, emulsifier: 8%, co-emulsifier: 1.5%, stabilizer: 5%.
[0029] The emulsifier is Span 60 and Tween 20 in a ratio of 1:1.
[0030] The co-emulsifier is polyethylene glycol.
[0031] The stabilizer is sodium carboxymethyl cellulose.
[0032] The preparation process of the semi-clear oral preparation composition of coenzyme Q10 in this example is as follows: at a temperature of 80 °C, first dissolve coenzyme Q10 in the emulsifier and co-emulsifier of the recipe, add sodium carboxymethyl cellulose Aqueous solution, the final solution was prepared 30 minutes after high shearing at 2000 rpm.
[0033] The beneficial effects of this embodiment are: (1) The appearance of the prepared microemulsion composition is light yellow and clear liquid. (2) After diluting the prepared microemulsion composition by 50...
Example Embodiment
[0034] Example 2
[0035] Coenzyme Q in this example 10 The components of the semi-clear oral preparation composition and their weight percentages are:
[0036] Coenzyme Q10: 0.5%, emulsifier: 2%, co-emulsifier: 1.5%, stabilizer: 5%.
[0037] The emulsifier is sucrose ester.
[0038] The co-emulsifier is polyethylene glycol.
[0039] The stabilizer is sodium carboxymethyl cellulose.
[0040] Coenzyme Q in this example 10 The preparation process of the semi-clear oral preparation composition is as follows: under the condition temperature of 35 ℃, the coenzyme Q 10 Dissolve in the sucrose ester and polyethylene glycol of the recipe amount first, add the aqueous solution containing sodium carboxymethyl cellulose, and prepare the final solution after 15 minutes of high-speed shearing at 4000 rpm.
[0041] The beneficial effects of this embodiment are: (1) The appearance of the prepared microemulsion composition is light yellow and clear liquid. (2) After diluting the prepar...
Example Embodiment
[0042] Example 3
[0043] Coenzyme Q in this example 10 The components of the semi-clear oral preparation composition and their weight percentages are:
[0044] Coenzyme Q10: 2%, emulsifier: 5%, co-emulsifier: 10%, stabilizer: 5%.
[0045] The emulsifier is sucrose ester, the co-emulsifier is propylene glycol, and the stabilizer is xanthan gum.
[0046]Coenzyme Q in this example 10 The preparation process of the semi-clear oral preparation composition is as follows: at a temperature of 55 ° C, the coenzyme Q 10 Dissolve in the sucrose ester and polyethylene glycol of the prescription amount first, add the aqueous solution containing xanthan gum, and prepare the final solution after 10 minutes of high-speed shearing at 20,000 rpm.
[0047] The beneficial effects of this embodiment are: (1) The appearance of the prepared microemulsion composition is light yellow and semi-clear liquid. (2) After diluting the prepared microemulsion composition by 50 times, the measured averag...
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