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Clear oral preparation with coenzyme Q10 and preparation method thereof

A technology for oral preparations and coenzymes, which is applied in the field of clear oral preparations containing coenzyme Q10 and its preparation, can solve the problems of poor stability, complicated preparation process and unsuitable storage for a long time, and achieves the effects of convenient storage, simple equipment and improved curative effect.

Active Publication Date: 2010-06-23
SHENZHOU BIOLOGY & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a 10 Clarified oral preparation and preparation method thereof, for oral, high stability, clarified coenzyme Q 10 The preparation overcomes outstanding defects such as poor stability, not suitable for long-term storage, and complicated preparation process. This technology does not require special equipment, is simple to operate, low in cost, and easy to store

Method used

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  • Clear oral preparation with coenzyme Q10 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Coenzyme Q in this example 10 Components and percentages by weight of the semi-clear oral preparation composition are:

[0028] Coenzyme Q10: 4%, emulsifier: 8%, co-emulsifier: 1.5%, stabilizer: 5%.

[0029] The emulsifier is Span 60 and Tween 20 in a ratio of 1:1.

[0030] Described co-emulsifier is polyethylene glycol.

[0031] The stabilizer is sodium carboxymethylcellulose.

[0032] The preparation process of the coenzyme Q10 semi-clear oral preparation composition in this example is as follows: at a temperature of 80°C, first dissolve coenzyme Q10 in the emulsifier and co-emulsifier of the prescribed amount, add carboxymethyl cellulose sodium Aqueous solution, 30 minutes after high shearing at 2000rpm to prepare the final solution.

[0033] The beneficial effects of this embodiment are: (1) The appearance of the prepared microemulsion composition is light yellow and clear liquid. (2) After diluting the prepared microemulsion composition 50 times, the measured ...

Embodiment 2

[0035] Coenzyme Q in this example 10 Components and percentages by weight of the semi-clear oral preparation composition are:

[0036] Coenzyme Q10: 0.5%, emulsifier: 2%, co-emulsifier: 1.5%, stabilizer: 5%.

[0037] Described emulsifier is sucrose ester.

[0038] Described co-emulsifier is polyethylene glycol.

[0039] The stabilizer is sodium carboxymethylcellulose.

[0040] Coenzyme Q in this example 10 The preparation process of the semi-clear oral preparation composition is as follows: at a temperature of 35°C, coenzyme Q 10 Dissolve in the prescribed amount of sucrose ester and polyethylene glycol, add an aqueous solution containing sodium carboxymethylcellulose, and shear at 4000 rpm for 15 minutes to prepare the final solution.

[0041] The beneficial effects of this embodiment are: (1) The appearance of the prepared microemulsion composition is light yellow and clear liquid. (2) after the microemulsion composition of preparation is diluted 50 times, measure mean...

Embodiment 3

[0043] Coenzyme Q in this example 10 Components and percentages by weight of the semi-clear oral preparation composition are:

[0044] Coenzyme Q10: 2%, emulsifier: 5%, co-emulsifier: 10%, stabilizer: 5%.

[0045] The emulsifier is sucrose ester, the co-emulsifier is propylene glycol, and the stabilizer is xanthan gum.

[0046]Coenzyme Q in this example 10 The preparation process of the semi-clear oral preparation composition is as follows: at a temperature of 55°C, coenzyme Q 10 First dissolve in the prescribed amount of sucrose ester and polyethylene glycol, add an aqueous solution containing xanthan gum, and prepare the final solution after 10 minutes of high-speed shearing at 20,000 rpm.

[0047] The beneficial effects of this embodiment are: (1) The appearance of the prepared microemulsion composition is light yellow and semi-clear liquid. (2) After the prepared microemulsion composition is diluted 50 times, the measured average particle diameter is 70nm, which meets ...

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Abstract

The invention relates to a clear oral preparation with coenzyme Q10 and a preparation method thereof, belonging to the food additive technical field. The oral preparation comprises the following raw materials by weight percent: 0.1%-10% of coenzyme Q10, 0.5%-30% of emulsifier, 5-20% of co-emulsifier, 0.5%-10% of stabilizer and the balance water. The preparation process comprises the following steps: weighting the raw materials according to the formula, firstly dissolving coenzyme Q10 in emulsifier and co-emulsifier, adding the obtained mixture in a stabilizer aqueous solution to form a uniform mixed solution, and finally preparing a finished solution through high speed shearing. The invention has the advantages that the technology does not use organic solvent, the desired devices are simple, clear and uniform nanometer disperse system with coenzyme Q10 can be prepared, the system has good dispersibility, the bioavailability can be improved, and the coenzyme Q10 aqueous solution can bestored stably for over one year.

Description

technical field [0001] The invention belongs to the technical field of food additives, and specifically provides a 10 Clarified oral formulations of and processes for their preparation. Background technique [0002] coenzyme Q 10 It is a fat-soluble quinone compound widely present in living organisms. Coenzyme Q at room temperature 10 It is orange-yellow crystalline powder, melting point (49-52°C), odorless and tasteless. It is easy to decompose under light, relatively stable to humidity and temperature, easily soluble in chloroform, benzene, carbon tetrachloride, insoluble in water and methanol. [0003] coenzyme Q 10 Combined with the inner membrane of mitochondria in the cells of animals, plants, microorganisms, etc., it is an important natural antioxidant and non-specific immune enhancer produced by the cells themselves. [0004] In the field of clinical, health care products and cosmetics, coenzyme Q 10 have a wide range of applications. coenzyme Q 10 It has an...

Claims

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Application Information

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IPC IPC(8): A23L1/30A23L33/10
Inventor 王小雪庞欣印红
Owner SHENZHOU BIOLOGY & TECH CO LTD
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