Auto-fluorescence molecule image system

A technology of molecular imaging and autofluorescence, which is applied in the field of subject knowledge and optical imaging theory, can solve the problems of inability to accurately select the visible area and inconvenient file search, and achieve the effect of low signal-to-noise ratio and improved accuracy

Active Publication Date: 2010-07-07
INST OF AUTOMATION CHINESE ACAD OF SCI
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Problems solved by technology

This method cannot adapt to the needs of measured objects of different sizes. When the sizes of the measured objects vary greatly, the fixed four positions may not be able to meet the acc

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  • Auto-fluorescence molecule image system
  • Auto-fluorescence molecule image system
  • Auto-fluorescence molecule image system

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Embodiment Construction

[0028] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0029] Such as figure 1 The autofluorescence molecular imaging system involved in the present invention mainly includes two aspects of a mechanical image information acquisition part 1 and a control part 2, wherein:

[0030] The image information collecting part 1 is made of camera obscura 11, CCD camera 12, camera lens 13, loading lifting platform 14 and CCD camera control box 15, and CCD camera 12, lens 13 and loading lifting platform 14 are placed in the dark box 11, and CCD camera 12 Connect with the CCD camera control box 15, and the CCD camera 12 adopts the CCD camera 12 cooled by liquid nitrogen. The dark box 11 is made of special materials, and its function is to isolate the fluorescent light inside the box and the external light noise. In the dark box 11, it is necessary to obtain background images by turning on the light source and fluorescen...

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Abstract

The invention belongs to an auto-fluorescence molecule image system which comprises a camera bellows, a CCD camera lens control module, an image processing module, an interactive analysis module and a database module. A system factor corrected by an integrating sphere can be converted into a photon density in an interesting area by the system through a pixel value. The system can work after a temperature value of the CCD camera is set and locked. Firstly, the light source in the camera bellows is opened to shoot an outline of a target object, then the light source is closed to capture a fluorescence signal which projects the outline of the detected object, and the signal is superposed with the outline image. User can choose the interesting area by using a selecting tool so as to acquire a photon density value for performing scientific research. The system of the invention can provide a database function for the user to conveniently manage the data and preview the images. The system of the invention has the advantages of reasonable structure, obvious function, convenient operation, low cost, wide application in the field of researching the small animals in non-invasive biologic experiment.

Description

technical field [0001] The invention belongs to the technical field of molecular imaging, and relates to subject knowledge such as optical imaging theory, computer image processing technology, mathematical modeling and the like. It includes in vivo fluorescence imaging detection equipment, control unit, image processing and data analysis and management, especially a complete set of molecular imaging system suitable for in vivo and non-invasive scientific research on small animals in biology. Background technique [0002] Autofluorescence imaging technology is an emerging optical molecular imaging technology in living animals in recent years. Bioautofluorescence is to mark cells or DNA with luciferase gene, and integrate the plasmid vector containing Fluc gene into the cell or the chromosomal DNA of the cell to express luciferase. In the presence of ATP and oxygen, if the substrate luciferin is injected into a living animal, luciferase will catalyze the oxidation reaction of...

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Application Information

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IPC IPC(8): A61B5/00G06F17/30G06T7/00G06T7/70
Inventor 田捷杨鑫常志军邢雨
Owner INST OF AUTOMATION CHINESE ACAD OF SCI
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