Washing liquor for operation and method for preparing same

A technology of surgical flushing liquid and liquid preparation, which is applied in the direction of surgical drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problem of poor killing effect of drug-resistant strains, lack of tissue repair and regeneration, antibacterial and Low antibacterial efficacy and other issues, to achieve the effect of helping tissue repair and regeneration, the process conditions are not harsh, and promoting wound healing

Inactive Publication Date: 2010-07-07
苏州汇涵医用科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Invention patent authorization announcement number CN1134213C discloses the preparation method of silver-containing bactericide, although the patent scheme does not mention the use in the description, it can be known from the raw materials used and the target product (silver-containing bactericide) that it can only be used It is used in the disinfection of utensils in daily life or the disinfection of human oral cavity, such as in mouthwash
This patent solution has the function and stability of surgical flushing and prevention of surgical adhesion as claimed in the 10-11 line on page 2 of the description, and has no toxic and side effects, but the formula is complicated, the bacteriostatic and antibacterial efficacy is low, and it is resistant to drug resistance. Poor killing effect of strains, lack of promotion of tissue repair and regeneration, and hard to avoid scar formation are the deficiencies of this patent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A) 0.09g of nano-scale silver powder, that is, nano-silver powder with a purity of 99.99% and a particle size of 10-25nm, which can be obtained from commercial channels or can be self-made, is added to a purity of 0.08-0.12μs / cm Stir evenly in 10g of deionized water, the container used both can be metal container, also can be plastic container, and metal container is as stainless steel container, and plastic container is as polyethylene plastic container, obtains silver powder body fluid, and the silver powder used in the present embodiment is preferred It is not limited to use nano-silver powder produced and sold by China Shanghai Denaf Nano Technology Co., Ltd. The purity of this nano-silver powder is 99.99%, and the particle size is 10-25nm. If you make your own silver powder, you can pass It can be realized in the following way. First put the silver particles or silver nuggets with a purity of 99.99% into the circulating jet mill for pre-grinding. The powder is proc...

Embodiment 2

[0035] Only change the amount of silver powder in step A) to 0.1g, and change the deionized water to distilled water with a purity of 0.08-0.12 μs / cm;

[0036] Only change the phosphoric acid in step B) to reagent grade 0.24g citric acid, change the time of acidification treatment to 24min, and change the pH value to 1.2;

[0037] Only change the amount of mannitol in step C) to 0.35g, change the deionized water to distilled water with a purity of 0.08-0.12μs / cm, and change the stirring time to 16min;

[0038] Only change the amount of medical gelatin in step D) to 0.38g, change the deionized water to distilled water with a purity of 0.08-0.12μs / cm, change the dissolution temperature to 58°C, and change the stirring and subsequent stirring time to 8 minutes , the mass percentage concentration of hydrogen peroxide was changed to 27%, the amount of hydrogen peroxide was changed to 6.8g, and the time of endotoxin inactivation treatment was changed to 35min;

[0039] Only change ...

Embodiment 3

[0042] Only change the amount of silver powder in step A) to 0.12g;

[0043] Only change the amount of phosphoric acid in step B) to 0.26g, change the time of acidification treatment to 23min, and change the pH value to 1.3;

[0044] Only change the amount of mannitol in step C) to 0.4g, and the stirring time to 17min;

[0045] Only change the medical gelatin in step D) to natural silk fibroin (the natural silk fibroin preferably uses the natural silk fibroin produced by Wuxi Biological Products Co., Ltd., Jiangsu Province, China), the amount of natural silk fibroin is 0.4g, The dissolution temperature is changed to normal temperature, and the stirring time is changed to 7 minutes. This step does not need to use bactericide, that is, hydrogen peroxide is not used, and the suspension liquid obtained is a natural silk fibroin solution;

[0046] Only change the amount of deionized water in step E) to 968.82g, change the stirring time to 7min, and change the time to continue stir...

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PUM

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Abstract

The invention discloses washing liquor for an operation and a method for preparing the same, which belong to the technical field of medicaments for medical operations. Each 1,000 g of washing liquor finished product comprises 0.08 to 0.16 g of silver powder, 0.3 to 0.5 g of stabilizing agent, 0.3 to 0.5 g of suspending agent, 0.2 to 0.3 g of ternary acid, 6 to 8 g of bactericide and the balance of water. The technical scheme provided by the invention has the advantages of strong effect, controlled release, strong broad-spectrum antibacterial property and permeability, wound healing promotion, no drug resistance, contribution to tissue repair and regeneration and scar formation prevention, safety, no toxicity and no irritation; therefore, the washing liquor is suitable for washing in the operation. The preparation method of the invention has fewer steps and easy process condition, and is favorable for industrial scaled-up production.

Description

technical field [0001] The invention belongs to the technical field of medication for medical operations, and in particular relates to an operation flushing liquid, and also relates to a preparation method of the operation flushing liquid. Background technique [0002] Currently in the medical department (hospital) clinically widely used surgical rinsing solutions include chlorhexidine rinsing solution, brogermine rinsing solution, Jieeryin rinsing solution, metronidazole rinsing solution, gentamicin normal saline rinsing solution, mannitol rinsing solution solution, active iodine flushing solution, carboxymethyl chitin saline flushing solution, and so on. Although these surgical rinsing fluids can meet the clinical requirements, they have the following disadvantages: one is that the antibacterial and antibacterial effects are weak, and it is easy to cause surgical adhesion and wound infection; the other is that the wound healing period is long; the third is that it does not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/08A61K47/42A61P41/00A61P31/04
Inventor 冯永良孟孝平孟勇朱世辉张琦
Owner 苏州汇涵医用科技发展有限公司
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