Magnetic molecular targeted ultrasound contrast agent microsphere and preparation method thereof

An ultrasonic contrast agent and microsphere technology, applied in the direction of echo/ultrasonic imaging agent, can solve the problems of unsatisfactory and insufficient imaging effect, and achieve the effect of less equipment investment, simple operation, and easy process amplification
CN101780284AInactive Publication Date: 2010-07-21NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
Publication Date
2010-07-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel magnetic molecular targeted ultrasound contrast agent, in particular to a gas-wrapped magnetic liposome microsphere suspension with the mean diameter of 1-4 micrometers and a preparation method thereof. The preparation method of the magnetic molecular targeted ultrasound contrast agent microsphere comprises a condition that a lipid layer of the microsphere and / or the surface of the lipid layer contains (or connects) magnetic response materials. A contrast agent microsphere wall material contains phospholipids, polyethylene glycol (PEG), PEG phospholipid polymers, biotinylated and / or polypeptide modificatory PEG phospholipid polymer, poloxamer, ligands (monoclonal antibodies or polypeptide, and the like) and the magnetic response materials and / or avidin bridging materials, wherein the ligand (monoclonal antibodies or polypeptide, and the like) has specific affinity to target molecules, the wrapped gas is a fluorine carbon gas, and a solvent is an aqueous medium (distilled water). The invention also provides the preparation method of the magnetic molecular targeted ultrasound contrast agent microsphere, which comprises a condition that the specific ligand is connected with the microsphere in a covalence and avidin bridging way. The novel magnetic molecular targeted ultrasound contrast agent has good targeted developing effect, can be used for evaluating the change of vessel endothelial molecules of an arterious and venous system of an organic tissue and has good application prospect in treatment.
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Description

field of invention

[0001] The present invention relates to a novel molecular targeting ultrasound contrast agent with magnetic properties, that is, liposome microspheres with magnetic properties encapsulating fluorocarbon insoluble gases, and the surface of the microspheres is equipped with ligands with specific affinity for target molecules. And relate to its composition and preparation method. The magnetically targeted ultrasound contrast agent includes: the case where a magnetic response material is attached to the lipid layer of the contrast agent microsphere and / or on the surface of the lipid layer of the contrast agent microsphere. Background of the invention

[0002] Long before the obvious clinical manifestations of many important diseases, there are obvious pathophysiological changes at the cellular and molecular levels, and they run through the whole process of the disease. Therefore, evaluating the pathological imaging features of various diseased tissues and org...

Claims

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