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Preparation method of nano superfine fiber vascular prosthesis

An artificial blood vessel and ultra-fine fiber technology, applied in the field of artificial blood vessels, can solve problems such as cell vascular cavity stenosis, and achieve the effects of avoiding vascular cavity stenosis, improving porosity, and facilitating vascular structure and strength shaping.

Inactive Publication Date: 2010-07-28
王深明 +6
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Problems solved by technology

[0004] However, the above-mentioned artificial blood vessels often cause cells to migrate and proliferate to the subendothelial layer, resulting in narrowing of the vessel lumen.

Method used

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Embodiment Construction

[0018] Electrospinning is a process that uses a polymer solution or melt to form a jet stream under the action of a strong electric field for spinning. In recent years, electrospinning, as an effective way to continuously produce nanofibers, has attracted widespread attention. At present, more than 30 polymers have been successfully electrospun in the world. The diameter of fibers produced by electrospinning technology generally ranges from 3nm to 5um, which is several orders of magnitude smaller than the diameter of fibers produced by conventional methods. These excellent properties that cannot be obtained by traditional methods endow electrospun fibers with a wide range of application prospects. In addition, electrospinning technology also has the advantages of rapidity, high efficiency, simple equipment, and easy operation. It can be used to prepare complex, suture-free scaffolds, and is an effective way to control the morphology, porosity and composition of polymer biologi...

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Abstract

The invention discloses a preparation method of nano superfine fiber vascular prosthesis, which comprises the following steps that: the mixed solution of N, N-dimethylformamide and tetrahydrofuran in the mass ratio of 3:7 serves as solvent to prepare polyurethane spinning solution with the mass percentage of 10 percent, and the polyurethane spinning solution stays still and is deaerated; the prepared spinning solution is put into a solution storage device of an electro-spinning device, and the flow rate of the spinning solution is adjusted; according to the preparation requirements, receiving sticks with different diameters are selected; the distance between an injection device of the electro-spinning device and the receiving sticks is adjusted; the receiving sticks are grounded; and a high-voltage static generator is turned on, the static spinning voltage is set, a high-voltage power supply supplies a strong electric field between the injection device and a collection device, after a period of time is waited, the power supply is disconnected, the receiving sticks are detached, and the vascular prosthesis is taken down. The vascular prosthesis which is prepared by the electro-spinning device and the special solution has rich porosity, facilitates inner and outer layered material exchange and cell signal transduction, and prevents cells from migrating and proliferating towards the subendothelial layer and causing vein stenosis.

Description

technical field [0001] The invention relates to artificial blood vessels, in particular to a preparation method of nanometer superfine fiber artificial blood vessels. Background technique [0002] Since Meadox successfully developed polyester braided artificial blood vessels (Dacron) in 1957, and William pioneered expanded polytetrafluoroethylene (ePTFE) artificial blood vessels (Gore-Tex) in 1970, the research and development and application of artificial blood vessels have a history of about 50 years. . During the period, various artificial blood vessel products of different materials were launched, the most important ones were microporous silicone rubber artificial blood vessels (the main advantage is good beat dynamic compliance), block polyurethane artificial blood vessels (ultra-thin and elastic, good mechanical compliance) , biodegradable polydioxanone artificial blood vessels and polylactic acid-polyglycolic acid copolymer artificial blood vessels (Polyglactin 910),...

Claims

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Application Information

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IPC IPC(8): A61L27/18D01D5/00
Inventor 王深明胡作军徐安武赵勇刘瑞明贺薇李梓伦
Owner 王深明
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