Bergenin and cetirizine dihydrochloride compound oral administration preparation

A technology of cetirizine hydrochloride and petrolatum, which is applied in the field of medicine, can solve the problems of high medication frequency, low bioavailability of petrolatin, can not meet the long-term medication requirements of patients with chronic bronchitis and bronchial asthma, etc. Significant, long-lasting, well-tolerated effects

Active Publication Date: 2011-07-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, there are still some unsatisfactory aspects in the curative effect of the existing compound common preparations of petracenin: on the one hand, the shortcoming of low bioavailability of petracenin; on the other hand, chlorpheniramine maleate has both Anticholinergic and strong central nervous system inhibitory effect, easy to cause drowsiness, dizziness, headache and other adverse reactions
Moreover, both medicines have the disadvantage of taking more medicines, which obviously cannot meet the long-term medication requirements of patients with chronic bronchitis and bronchial asthma.

Method used

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  • Bergenin and cetirizine dihydrochloride compound oral administration preparation
  • Bergenin and cetirizine dihydrochloride compound oral administration preparation
  • Bergenin and cetirizine dihydrochloride compound oral administration preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Sustained release tablet core:

[0107] Begenin 187.5g

[0108] Hydroxypropyl Methyl Cellulose K4M 27g

[0109] Lactose 39g

[0110] Sodium bicarbonate 45g

[0111] 5% PVPk30 ethanol solution appropriate amount

[0112] Magnesium Stearate 1.5g

[0113] Made into 1000 pieces

[0114] Immediate Release Coating:

[0115] Cetirizine Hydrochloride 5g

[0116] Easy Release 4g

[0117] Made into 1000 pieces

[0118] Pass the raw and auxiliary materials through 80 or 100 mesh sieves respectively, mix petgenin, lactose, and HPMC according to the equal amount incremental method, use 5% PVPk30 ethanol solution as the binder to make soft materials, and pass through 20-24 mesh sieves to granulate , dried at 45-60°C for 1.5-2 hours, and granulated for later use. Sodium bicarbonate is made into a soft material with 5% PVPk30 ethanol solution as a binder, dried at 40-50°C for 1.5-2 hours, and granulated for later use. The two kinds of granules are uniformly mixed according t...

Embodiment 2

[0141] Sustained release tablet core:

[0142] Begenin 375g

[0143] Hydroxypropyl Methyl Cellulose K4M 40g

[0144] Hydroxypropyl Methyl Cellulose E5 020g

[0145] Lactose 75g

[0146] Sodium bicarbonate 90g

[0147] Proper amount of PVPk30 ethanol solution

[0148] Magnesium Stearate 3g

[0149] Made into 1000 pieces

[0150] Immediate Release Coating:

[0151] Cetirizine Hydrochloride 10g

[0152] Opadry 9g

[0153] Made into 1000 pieces

[0154] Separately pass lactose, HPMC and petogenin through 80 or 100 mesh sieves, mix the above-mentioned raw and auxiliary materials evenly according to the method of equal addition, use 5-10% PVPk30 ethanol solution as a binder to make soft materials, and pass through 20-24 mesh sieves Granulate, dry at 45-60°C for 2-3 hours, and prepare the granules for later use. Sodium bicarbonate is made into a soft material with 5-10% PVPk30 ethanol solution as a binder, dried at 40-50°C for 1.5-2 hours, and granulated for later use. Th...

Embodiment 3

[0156] Sustained release tablet core:

[0157] Begenin 125g

[0158] Hydroxypropyl Methyl Cellulose K4M 20g

[0159] Mannitol 30g

[0160] Sodium carbonate 25g

[0161] Proper amount of PVPk30 ethanol solution

[0162] Magnesium Stearate 1g

[0163] Made into 1000 pieces

[0164] Immediate Release Coating:

[0165] Dithirizine Hydrochloride 2g

[0166] Easy Release 4g

[0167] Made into 1000 pieces

[0168] Sieve mannitol, HPMC K4M, and petracenin through 80 or 100 mesh sieves, mix the above-mentioned raw and auxiliary materials evenly according to the method of equal volume addition, use 5-10% PVPk30 ethanol solution as a binder to make a soft material, and pass 20-24 Granulate with a mesh sieve, dry at 45-60°C for 1-2 hours, and prepare the granules for later use. Sodium carbonate is made into a soft material with 5-10% PVPk30 ethanol solution as a binder, dried at 40-50°C for 1.5-2 hours, and granulated for later use. The two kinds of granules are mixed uniformly...

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Abstract

The invention discloses a compound oral administration preparation containing bergenin\cetirizine dihydrochloride, in particular to a gastric stasis floating type slow-release tablet, which mainly consists of a fast-release coating layer containing the cetirizine dihydrochloride and a slow-release tablet core layer containing the bergenin. The invention further realizes the fast release of the cetirizine dihydrochloride and the gastric stasis and the slow release of the bergenin, and improves the curative effect of the bergenin\cetirizine dihydrochloride compound oral administration preparation. Pharmacodynamic experiments prove that the medicine composition has the obvious effects of relieving the cough, eliminating the phlegm and preventing the asthma, has small side effect, and can be used for treating chronic bronchitis and bronchial asthma.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound oral dosage form of petracenin\cetirizine hydrochloride, in particular to a gastric retention floating sustained-release tablet. Background technique [0002] Chronic bronchitis and bronchial asthma are clinically common respiratory diseases, and the prevalence rate in my country is as high as 1-4%. Prevalence increases with age, reaching as high as 15 percent or more in people over 50 years of age. The clinical manifestations are long-term repeated cough and expectoration, accompanied by symptoms such as wheezing, shortness of breath, and dyspnea. If it cannot be controlled in time and it is delayed repeatedly, it can deteriorate and develop into chronic obstructive emphysema, cor pulmonale, etc., which will seriously endanger human health and even lead to death. [0003] Begenin has a good antitussive and expectorant effect, which can improve immunity....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/495A61K31/366A61K9/36A61P11/00A61P11/06
Inventor 黄园李凤张志荣
Owner SICHUAN UNIV
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