Preparation and application method of scutellarin

A technology of scutellarin and breviscapine, which is applied in the field of preparation of pharmaceutical raw materials, can solve the problem that there are not many reports on the preparation method of scutellarin active ingredients

Inactive Publication Date: 2010-09-29
GUIYANG MEDICAL UNIVERSITY
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Problems solved by technology

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Method used

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Examples

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Embodiment

[0041] First, take 15.0 kg of Erigeron breviscapus medicinal material, and reflux leaching with 8 times the amount of ethanol with a mass fraction of 90% for 3 times, each time for 1.5 hours.

[0042] Next, filter the leaching solution in the previous step, reduce the pressure to 0.08MPa, recover ethanol, and obtain the extract for future use.

[0043] Afterwards, use the petroleum ether of 2% by mass fraction, the ethyl acetate of 2% by massfraction, the n-butanol system of 3% by massfraction to extract the medicinal extract of previous step respectively, obtain petroleum ether part 120.0g, ethyl acetate part 180.0g , 330.0 g of n-butanol fraction.

[0044] Dissolve 180.0 g of the ethyl acetate part of the previous step with a small amount of ethanol with a mass fraction of 1.7%;

[0045] Add 150.0g 250 mesh silica gel (i.e. normal phase column chromatography silica gel) and stir, dry naturally, grind finely, cross 80 mesh sieves; through 1200.0g 300 mesh silica gel column c...

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Abstract

The invention discloses a preparation method of scutellarin, comprising the following steps of: (1) refluxing and extracting a medicinal material of erigeron breviscapus with ethanol; (2) filtering a leaching solution in the last step and carrying out pressure reduction to recover ethanol to obtain extract for later use; (3) respectively extracting with petroleum ether, ethyl acetate and normal butanol to obtain a petroleum ether extraction part, an ethyl acetate extraction part and a normal butanol extraction part; (4) dissolving the ethyl acetate part with ethanol; (5) adding silica gel and stirring, naturally drying, porphyrizing and sieving to obtain fine powder; (6) through gel column chromatography, carrying out gradient elution on the petroleum ether and the ethyl acetate and collecting by section; and (7) carrying out gel column chromatography on the ethyl acetate extraction part and elution by the petroleum ether and isopropanol and checking and combining same speckle parts according to a thin layer to obtain a compound of scutellarin. The scutellarin extract is used as an active component and is used for preparing a medicine for preventing and treating neurodegenerative diseases. The method can be used for preparing the scutellarin the purity of which is as high as 95 percent; and the raw material can be used for preparing a medicine for treating senile dementia and serves the human health.

Description

technical field [0001] The present invention relates to the preparation of pharmaceutical raw materials, in particular, to the preparation method of scutellarin, and also to its application method. Background technique [0002] Herba Erigerontis, which is mainly distributed in Guizhou, Hunan, Guangxi and other places, is the dried whole herb of Ergeron breviscapus, a plant in the Compositae family. At present, it is believed that breviscapine and its extracts can improve the clinical symptoms of acute cerebral infarction, enhance the recovery of neurological function in patients with acute ischemic stroke, have obvious protective effects on cerebral ischemia, and protect the optic nerve of glaucoma; dilate coronary arteries , Increase myocardial blood flow, reduce platelet accumulation, improve microcirculation, improve coronary heart disease angina pectoris and other effects. [0003] Erigeron breviscapus is a single traditional Chinese medicine widely used clinically. So...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40A61K31/352A61P25/28
Inventor 官志忠齐晓岚黄勇王永林郭莉莉
Owner GUIYANG MEDICAL UNIVERSITY
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