Micro-fluid reactor, using method and application thereof

Abstract

The invention relates to an automatic high-pass micro-fluid reactor, a using method and application thereof. The micro-fluid reactor is a composite micro-fluid control chip constructed based on a surface hydrophilic material and a surface hydrophobic material, and comprises a plurality of radial micro tubes and micro cavities; and the micro-fluid reactor realizes automatic sample introduction of trace liquid samples in the micro tubes through a capillary acting force, and meanwhile realizes quantitative distribution and mixing of the trace samples by combining a capillary drain valve and a centrifugal force. The micro-fluid reactor can be applied to high-pass screening of chemical synthesis conditions and biochemical reaction conditions, and greatly saves manpower and cost. Compared with the conventional micro-fluid reactor, the micro-fluid reactor of the invention has a simple structure; and the using method does not need complex drive equipment and devices, simplifies the operation flow of the micro-fluid reactor, and is favorable for wide application of the micro-fluid reactor.

Description

technical field [0001] The invention relates to an automatic, high-throughput microfluidic reactor, a use method and an application thereof. The provided microfluidic reactor can be applied to the fields of chemistry, pharmacy and biology, especially for high-throughput screening of chemical synthesis and biochemical reaction conditions. Background technique [0002] "Microfluidic reactor" refers to a new type of miniaturized chemical reactor manufactured by micro-processing technology. In the past ten years, the application of microfluidic reactors has shown its advantages. It not only has the advantages of small space required, less sample consumption and fast response, but also has more environmental protection and safety characteristics than traditional equipment. Due to the reduction of the scale, in the microfluidic reactor, the surface volume ratio of the reaction system is greatly increased, the mass transfer path is extremely short, and the heat transfer speed is e...

AI Technical Summary

Problems solved by technology

Although a lot of research has been done on microfluidic reactors at home and abroad, and many microfluidic reactor products have been developed, such as microfluidic reactors based on multiphase laminar flow mixing [Tokeshi M, Minagawa T, Uchiyama K, Hibara A , Sato K, Hisamoto H, Kitamori T. Continuous-flow chemical processing on a microchip by combining microunit operations and a multiphase flow network. Analytical Chemistry, 2002, 74(7): 1565-1571.] and droplet-based microfluidic reactions [Cygan ZT, Cabral JT, Beers KL, Amis EJ. Microfluidic platform for the generation of organic-phase microreactors. Langmuir. 2005, 21(8): 3629-3634.], but most of these microfluidic reactors require external precision Control equipment and units such as syringe pumps, air pressure sources, and microvalves have problems such as complex system structures and cumbersome controls, which greatly affect the promotion and application of microfluidic reactors.

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