Reinforced anti-adhesion composite gel, preparation method and application

A composite gel, anti-adhesion technology, applied in medical science, surgery, etc., can solve the problems of difficulty in ensuring the concentration and time of the wound site, unsatisfactory effect, etc., to prevent platelet aggregation and activation, enhance mechanical isolation effect, prevent whitening. The effect of protein exudation

Active Publication Date: 2010-10-27
SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a mechanical barrier, it covers tissue or organ wounds in the form of gel or film. It has the characteristics of good absorption and good biocompatibility, but it is absorbed and degraded in about 4 days in the body. However, the completion of adhesion after injury requires For more than 7 days, carboxymethyl cellulose, carboxymethyl chitosan, and hyaluronic acid alone are not effective in preventing adhesions
[0007] In recent years, carboxymethyl cellulose, carboxymethyl chitosan, and hyaluronic acid sugar have been used clinically to prevent adhesions. They are solutions or gels, but they will flow with the body position after being placed in the body. Ensure its concentration and time at the wound site

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 2.5 grams of pharmaceutical grade sodium carboxymethylcellulose, first add 80 milliliters of water for injection and heat it in a water bath (30-60°C) and stir to dissolve; add 50 milligrams of functional polypeptides, the amino acid sequence of which is: lysine-lysine- Threonine-serine-arginine-glycine-aspartic acid-serine, stir evenly; add 1.5 grams of chitosan (molecular weight 10,000-20,000), stir while adding, then add water for injection to 100 ml, stir evenly Until a flocculent-free uniform gel is formed, a strengthened anti-adhesion composite gel is obtained through sterilization treatment.

Embodiment 2

[0026] Weigh 2 grams of pharmaceutical grade carboxymethyl chitosan, first add 80 ml of water for injection and heat it in a water bath (30-60° C.) and stir to dissolve; add 60 micrograms of functional polypeptide, the amino acid sequence of which is: lysine-lysine- Cysteine-serine-arginine-glycine-aspartic acid-serine-cysteine-lysine-lysine (can be condensed into a ring), stir well; add 2.0 grams of chitosan ( Molecular weight 2000~3000), stirring while adding, and then adding water for injection to 100 ml and stirring evenly until forming a uniform gel without flocculation, and sterilized to obtain a strengthened anti-adhesion composite gel.

Embodiment 3

[0028] Weigh 1.5 grams of pharmaceutical grade hyaluronic acid, first add 80 ml of water for injection, heat it in a water bath (30-60°C) and stir to dissolve; add 100 micrograms of functional polypeptide, the amino acid sequence of which is: lysine-lysine-threonine -serine-arginine-glycine-aspartic acid-serine, stir evenly; add 0.05 grams of polylysine (molecular weight is 3000-5000), stir while adding, and then add water for injection to 100 ml and stir evenly to form No flocculent uniform gel, anti-adhesion compound gel strengthened after sterilization.

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Abstract

The invention relates to the field of biological medicinal materials, and discloses a reinforced anti-adhesion composite gel. The reinforced anti-adhesion composite gel comprises the following components in mass / volume ratio: 0.01 to 8 percent of polysaccharide with anionic groups, 0.0000001 to 1 percent of functional polypeptide with positive charge groups, and 0.05 to 5 percent of polysaccharide with cationic groups or cationic polymerized polypeptide or mixture of the two in any ratio. The invention also provides a preparation method for the reinforced anti-adhesion composite gel. The reinforced anti-adhesion composite gel can effectively reduce the occurrence of adhesion by adding the anti-adhesion functional polypeptide with polyelectrolyte interaction and the polysaccharide with cationic groups and / or cationic polymerized polypeptide into materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a composite gel with enhanced anti-adhesion function after surgery, a preparation method and application thereof. Background technique [0002] Adhesions between tissues and organs after surgical operations are clinically frequently occurring conditions. Adhesions are abnormal structures formed by the combination of connective tissue fiber bands and adjacent tissues or organs. Adhesion formation is universal, and it is reported that 50% to 100% of abdominal and pelvic surgeries can lead to different degrees of adhesions. Clinically serious complications caused by adhesions include intestinal obstruction, infertility, and chronic pelvic pain, which increase the difficulty of reoperation and the potential for further complications. Therefore, in-depth exploration of the causes of adhesion formation and the prevention and reduction of postoperative adhesions have become the key re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/04C08J3/075C08L5/08C08L5/06C08L1/08
Inventor 吴昌琳
Owner SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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