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Immune potentiator and recombinant IFN-alpha combined medicament

An immune enhancer, interferon technology, applied in the field of medicine, can solve the problems of decreased treatment effect, decreased interferon treatment rate, low cure rate and effective rate, etc.

Inactive Publication Date: 2010-11-03
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the process of treating diseases with interferon, it can stimulate the body to produce interferon antibodies (anti-IFN), making the treatment effect decline or the disease rebound. Some clinical studies have shown that the use of interferon for a long time can make the body produce interferon The probability of antibody is above 40%, which significantly reduces the treatment rate of interferon, which has a low cure rate and effective rate

Method used

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  • Immune potentiator and recombinant IFN-alpha combined medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1: Combination water injection of recombinant porcine α-interferon and vitamin C

[0091] Take recombinant porcine α-interferon 3 × 10 5 10,000 IU, 60.0 grams of vitamin C, appropriate amount of EDTA, sodium metabisulfite and sodium bicarbonate buffer are selected as pharmaceutical excipients, dissolved in appropriate amount of water, adjusted to pH between 5.0 and 7.0, filtered and sterilized, and packed into 10 bottles, Each bottle was 30 mL, and the compound water injection containing 1 million IU of recombinant porcine α-interferon and 200 mg of vitamin C was prepared in each bottle after sealing.

[0092] Application: Mainly used to treat porcine transmissible gastroenteritis and porcine epidemic diarrhea.

[0093] Usage and dosage: Intramuscular injection, one dose, 0.5mL of this product for small pigs (below 30kg), 1.0mL of this product for medium pigs (30-60kg), 1.5mL of this product for large pigs (above 60kg), once a day, consecutively 2-3 days.

Embodiment 2

[0094] Example 2: Water injection for the combination of recombinant porcine α-interferon and polymyocytes

[0095] Take recombinant porcine α-interferon 1×10 5 10,000 IU, 1000ml of polyinocytic injection (polyinocytic content 1mg / ml), appropriate amount of chloroform, zinc stearate and sodium carbonate buffer as pharmaceutical excipients, adjust the pH value between 6.0 and 7.0, filter out Bacteria, sub-packed into 100 bottles, each bottle 10mL, sealed to make a compound water injection containing 1 million IU of recombinant porcine α-interferon and 1 mg of polymyocyte.

[0096] Application: Broad-spectrum antiviral drug. It is mainly suitable for the treatment of various animal viral diseases, especially the treatment of viral diseases induced by livestock and poultry immune failure, such as swine fever, swine vesicular disease, foot-and-mouth disease, porcine transmissible gastroenteritis, etc., as well as immunodeficiency or low immunity disease. This product also has a...

Embodiment 3

[0098] Example 3: Combination water injection of recombinant porcine α-interferon and lactobacillus

[0099] Take recombinant porcine α-interferon 1×10 4 10,000 IU, 4 grams of Lactobacillus, appropriate amount of glycerin, chloroform, zinc stearate and phosphate buffer as pharmaceutical excipients, dissolved in water for injection, adjusted pH value between 5.0 and 6.5, filtered and sterilized, and packed into 100 bottles, 1 mL per bottle, sealed to prepare a compound water injection containing 1 million IU of recombinant porcine α-interferon and 40 mg of lactobacillus in each bottle.

[0100] Application: It is used to treat yellow scour and pullorum of piglets, diarrhea of ​​weaned piglets, porcine transmissible gastroenteritis and porcine epidemic diarrhea.

[0101] Usage and dosage: Intramuscular injection, one dose, 0.5mL of this product for small pigs (below 30kg), 1.0mL of this product for medium pigs (30-60kg), 1.5mL of this product for large pigs (above 60kg), once a...

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Abstract

The invention relates to an immune potentiator and recombinant IFN-alpha combined medicament. In the recombinant IFN-alpha and a compound preparation having synergism with the recombinant IFN-alpha, an immune potentiator may be one or the combination of several of vitamin C, poly IC, lactobacillus and pig spleen transfer factors. While treating diseases, the medicament can stimulate the organisms to continuously generate interferon so as to form a continuous treating process and achieve an aim of thoroughly curing diseases; and in addition, the medicament can also strengthen the resisting power of the organisms and have the effects of preventing diseases and avoiding secondary infection of diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a recombinant porcine alpha-interferon and a combination medicine having a synergistic effect on the recombinant porcine alpha-interferon. Background technique [0002] Porcine epidemic diarrhea (PED) and porcine transmissible gastroenteritis (TGE) are two viral infectious diseases that seriously threaten the pig industry. The pathogenic porcine epidemic diarrhea virus (PEDV) and porcine transmissible gastroenteritis virus ( TGEV) belong to the same coronavirus, with similar shape and the same target organs for reproduction. Outbreaks of these two diseases often result in mass deaths of newborn piglets. The existing general solution is to vaccinate. However, due to various reasons, sometimes it will inevitably cause immune failure, outbreak of disease, and bring certain difficulties to diagnosis and treatment. After immune failure, antibiotic treatment is often relied on, resul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61P31/14A61P31/12A61K31/375A61K38/17A61K35/74A61K31/787A61K35/747
Inventor 王小娥
Owner TIANJIN RINGPU BIO TECH
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