Water extract of turpinia formosana leaves and preparation method and application thereof

A technology of Radix Radix et Rhizoma, water extract, applied in the directions of drug combination, pharmaceutical formulation, plant raw material, etc., can solve problems such as high price, achieve the effects of reducing infection, preventing and treating influenza and its complications, and overcoming side effects

Active Publication Date: 2010-11-17
JIANGXI SHANXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine "Oseltamivir Phosphate (Tamiflu, (3R, 4R, 5S)-4-Acetamide-5-Amino-3(1-Propoxyethyl)-1-Cyclohexene-1 Carboxylic Acid Ethyl Phosphate "Salt)" is a neuraminidase inhibitor, which has a specific inhibitory effect on the entry of influenza virus into cells, but it is not only expensive, but also some patients experience vomiting, nausea, insomnia, headache, abdominal pain, diarrhea, dizziness, fatigue, Side effects such as nasal congestion, sore throat, and coughing

Method used

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  • Water extract of turpinia formosana leaves and preparation method and application thereof
  • Water extract of turpinia formosana leaves and preparation method and application thereof
  • Water extract of turpinia formosana leaves and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Preparation method: Take the round leaves of Shanxiang and add water to decoct twice, 3 hours each time, add 8 times the amount of water for the first time, add 8 times the amount of water for the second time, decoct for the second time and filter, combine the two decoction liquids, reduce Concentrate under pressure to a relative density of 1.22 (55-60°C), let cool, add ethanol to make the alcohol content reach 52%, stir well, let stand for 36 hours, filter, and concentrate the filtrate under reduced pressure to dryness to obtain the water extract .

Embodiment 2

[0031] Preparation method: Take the round leaves of Shanxiang and add water to decoct twice, 3 hours each time, add 8 times the amount of water for the first time, add 9 times the amount of water for the second time, filter, combine the two decoction liquids, and concentrate under reduced pressure to relative Density 1.22 (55-60°C), let it cool, add ethanol to make the alcohol content reach 58%, stir well, let it stand for 36 hours, filter, and concentrate the filtrate under reduced pressure to dryness to obtain the water extract of Rhizoma saponifolium.

Embodiment 3

[0033] Preparation method: Take the round leaves of Shanxiang and add water to decoct twice, each time for 2 hours, add 9 times the amount of water for the first time, add 8 times the amount of water for the second time, filter, combine the two decoction liquids, and concentrate under reduced pressure to relative Density 1.23 (55-60°C), let it cool, add ethanol to make the alcohol content reach 51%, stir well, let it stand for 24 hours, filter, and concentrate the filtrate under reduced pressure to dryness to obtain the water extract of Rhizoma saponifolium.

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Abstract

The invention relates to a water extract of turpinia formosana leaves, which is obtained from extracting the turpinia formosana leaves by adding water. The specific extraction method is as follows: taking the turpinia formosana leaves, and adding water to decoct twice or three times (1-3h for each time); filtering, merging, decompressing and concentrating the obtained decoction liquid into the relative density up to 1.18-1.27 (55-60 DEG C); and cooling, adding ethanol until the alcohol content reaches 40-60%, evenly stirring, keeping standing for 12-48h, filtering, decompressing and concentrating the obtained filtrate until the filtrate is dry to obtain the water extract of the turpinia formosana leaves. The extract can be taken as a neuraminidase inhibitor to prevent and treat influenza, and can be prepared into pharmaceutically acceptable dosage forms.

Description

technical field [0001] The present invention relates to a kind of water extract of Rhizoma chinensis and its preparation method and application. Background technique [0002] At present, influenza virus is becoming more and more serious, and influenza virus is closely related to respiratory diseases and systemic diseases caused by it. my country is one of the countries with high incidence of influenza. Not only has a large population, but also living habits are conducive to the transmission of influenza virus. The average number of episodes ranged from 0.3 to 0.7, and 2 to 4 in key groups. Influenza poses a serious threat to human beings, especially the emerging strains of influenza virus, which not only cause secondary infections of other microorganisms, but also directly lead to organ damage and allergic reactions leading to death. But there is no effective method and treatment means for treating influenza virus and its disease (influenza) at present, such as treating the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P11/00A61P31/16A61K127/00
Inventor 唐春山张华敏王燕平谢宁吕武清杨小玲刘地发李志勇程帆
Owner JIANGXI SHANXIANG PHARMA
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