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Application of paederosidic acid used for preparing analgesic drugs and/or anti-inflammatory drugs

A technology of gallic acid and analgesic drugs, which is applied in the direction of anti-inflammatory agents, drug combinations, non-central analgesics, etc., and can solve problems such as the absence of gallic acid

Inactive Publication Date: 2010-11-24
SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report in the prior art that gallizine can be used as an analgesic and / or anti-inflammatory drug

Method used

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  • Application of paederosidic acid used for preparing analgesic drugs and/or anti-inflammatory drugs
  • Application of paederosidic acid used for preparing analgesic drugs and/or anti-inflammatory drugs
  • Application of paederosidic acid used for preparing analgesic drugs and/or anti-inflammatory drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 , Paederoside acid (paederoside acid) preparation

[0022] Take 5 kilograms of the whole herb of Chickweed, wash it, break it, and then extract it with an 80% ethanol solution under reflux for 2 hours, collect the ethanol solution and concentrate it to dryness under reduced pressure to obtain 100 grams of extract;

[0023] Add 300ml of distilled water to the extract, stir to obtain a suspension of the extract;

[0024] Add 300ml of n-butanol solution to the suspension for extraction to obtain n-butanol extract, repeat the extraction 3 times, combine the n-butanol solution, concentrate to dryness, and obtain 20 g of dry extract;

[0025] Take the dry extract, and perform column chromatography with silica gel and ODS successively to obtain 1.2 g of crude extract of gallinaceous acid.

[0026] Preparative HPLC was used to purify the crude extract of gallic acid to obtain 500 mg of gallic acid.

[0027] The HPLC analysis was performed on the prepared gallinylic...

Embodiment 2

[0028] Example 2 , Gallic acid pharmacological experiment

[0029] 2.1. Mouse writhing experiment

[0030] This experiment was carried out according to the method described in "Pharmacological Experimental Methodology" (Edited by Xu Shuyun et al., third edition, Beijing, People's Health Publishing House, 2001, p.882-883), wherein, the blank (normal saline) was negative As a control, aspirin was used as a positive control to test the peripheral analgesic effect of gallic acid. The injection dosage and test results of the experimental drugs are shown in Table 1.

[0031] Table 1, the effect of gallinaceous acid on the writhing activity of mice caused by acetic acid ( n=10)

[0032]

[0033] The results in Table 1 show that the three doses of gallic acid 20mg / kg, 40mg / kg, and 60mg / kg have a significant inhibitory effect on the writhing of mice caused by intraperitoneal injection of acetic acid, and there is a certain dose relationship, Table 1 The results show that galli...

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Abstract

The invention provides application of paederosidic acid used for preparing analgesic drugs and / or anti-inflammatory drugs. The paederosidic acid provided by the invention has good peripheral analgesic effect and nervous centralis analgesic effect as well as favorable anti-inflammatory effect, thus the paederosidic acid can be used separately or / and together with other pharmaceutically available components to prepare the analgesic drugs and / or the anti-inflammatory drugs.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of gallic acid in the preparation of analgesic and / or anti-inflammatory drugs. Background technique [0002] Paederia scandens (Lour.) Merri. is a climbing vine of the Rubiaceae Paederia scandens, also known as "Paederia scandens", which is widely distributed in China, Japan, India, the Philippines, and the west coast of the United States. In China, Japan and some countries in Southeast Asia, Galloping vine has been used as folk traditional herbal medicine and food for thousands of years, especially in the treatment of toothache, chest pain, pain caused by hemorrhoids, rheumatoid arthritis, spleen inflammation and bacillary dysentery, etc. have significant curative effect. [0003] In recent years, there have been many reports that from the methanol extracts of the roots and stems of the plant, gallinaceous vine, gallinacein, cartilin, gal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P29/00A61P25/04
CPCA61K31/7048A61P25/02A61P25/04A61P29/00
Inventor 王永兵蒋毅
Owner SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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