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Sustained-release composition of cefaclor

A composition and technology of cephalosporins, which are applied in drug delivery, medical preparations of non-active ingredients, organic active ingredients, etc., can solve the problems of long complete release time and affecting curative effect

Active Publication Date: 2010-12-01
ZHEJIANG ANGLIKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this patent is that the complete release time is too long, which affects the curative effect

Method used

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  • Sustained-release composition of cefaclor
  • Sustained-release composition of cefaclor
  • Sustained-release composition of cefaclor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Raw materials (g)

[0021] Take cefaclor, sodium carboxymethyl cellulose, mannitol, povidone (K30), hypromellose (E5), and microcrystalline cellulose, sieve and mix well, and use 5% polyacrylic acid resin II ethanol solution Soft material, 16-mesh granulation, drying, 12-mesh granulation, adding magnesium stearate, mixing, tableting.

Embodiment 2

[0023] Raw materials

[0024] Sodium carboxymethyl cellulose

[0025] Take cefaclor, sodium carboxymethylcellulose, mannitol, hypromellose (K100M), and stearic acid, sieve and mix well, use 5% polyacrylic resin II ethanol solution to make soft material, and granulate with 16 mesh , dried, 12-mesh granules, added magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0027] Raw materials

[0028] Take cefaclor, sodium carboxymethylcellulose, sucrose, hypromellose (E5), hypromellose (100M) and stearic acid, sieve and mix thoroughly, and use 5% polyacrylic acid resin II ethanol solution Soft material, 16-mesh granulation, drying, 12-mesh granulation, adding magnesium stearate, mixing, tableting.

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Abstract

The invention relates to the technical field of drug release, in particular to a novel sustained-release composition of cefaclor. The sustained-release composition of cefaclor comprises 60-90% of cefaclor, 5-25% of water-soluble adhesives, 0.5-5% of water-insoluble retardants, 2-10% of porogenic agents and 2-15% of cellulose derivatives with water viscosity being more than 500mmPa.s by total weight of the composition. The sustained-release composition of cefaclor can be completely released within 4-8h, has sustained-release effect in bodies and is applicable to administration twice a day.

Description

Technical field [0001] The invention relates to the technical field of drug release, in particular to a novel slow-release composition of cefaclor. Background technique [0002] The half-life of many oral β-lactam antibiotics is very short. For example, the half-life of cefaclor in vivo is only 0.6 to 0.9 hours. Common cefaclor preparations are administered three or four times a day to achieve the therapeutic purpose. Too many times of administration caused many troubles for the patient, and therefore it was necessary to develop a preparation with fewer times of administration. [0003] Chinese patent CN99806823.3 discloses an effervescent intragastric floating preparation of cefaclor, which includes a swelling polymer and a gas-generating salt in addition to the main drug, and can release the medicine within 20 hours. The embodiment that released in a short time (4-8 hours). However, the effervescent intragastric floating preparation produces a large amount of gas in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/545A61K47/32A61K47/38A61P31/04
Inventor 徐成苗周军马海岭黄伟莉徐爱放
Owner ZHEJIANG ANGLIKANG PHARMA
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