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Preparation method of biological dressing containing nano silver, zinc and bismuth

A biological dressing, nano-silver technology, applied to the biological dressing of bismuth metal ions, containing nano-silver and zinc, medical biological dressing and its preparation field, can solve the problems that have not been reported in the application, achieve broad antibacterial spectrum, and promote wound repair , The effect of simple preparation process

Inactive Publication Date: 2010-12-29
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, biological dressings and applications containing nano-silver, zinc ions, and bismuth ions have not been reported.

Method used

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  • Preparation method of biological dressing containing nano silver, zinc and bismuth
  • Preparation method of biological dressing containing nano silver, zinc and bismuth
  • Preparation method of biological dressing containing nano silver, zinc and bismuth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 The preparation method of the sponge biological dressing containing nano-silver, zinc, bismuth, the steps are as follows:

[0033] (1) 10g chitosan is ground into fine powder;

[0034] (2) 0.005g of silver nitrate is ground into fine powder; 0.004g of zinc acetate is ground into fine powder; 0.004g of bismuth nitrate is ground into fine powder;

[0035] (3) mixing the chitosan fine powder obtained in (1) with the silver nitrate fine powder, zinc acetate fine powder and bismuth nitrate fine powder obtained in (2), fully grinding for 2 hours;

[0036] (4) Add 0.005 g of ascorbic acid to the fine powder of the mixture obtained in (3), and continue to fully grind for 2 hours;

[0037] (5) Add 500 ml of 1% aqueous acetic acid solution to the fine powder of the mixture obtained in (4), add 10 g of glycerin, add 10 g of isinglass, stir evenly, and vacuumize and degas;

[0038] (6) Pour the solution obtained in (5) into a mold, freeze at -30°C for 20 hours, and f...

Embodiment 2

[0039] Embodiment 2 The preparation method of the sponge biological dressing containing nano-silver, zinc, bismuth, the steps are as follows:

[0040] (1) 100g chitosan is ground into fine powder;

[0041] (2) 0.0005g silver nitrate is ground into fine powder; 0.0004g zinc nitrate is ground into fine powder; Bismuth hydroxide 0.0004g is ground into fine powder;

[0042] (3) mixing the chitosan fine powder obtained in (1) with the silver nitrate fine powder, zinc nitrate fine powder and bismuth hydroxide fine powder obtained in (2), fully grinding for 3 hours;

[0043] (4) Add 0.001 g of N-acetylglucosamine to the fine powder of the mixture obtained in (3), and continue to fully grind for 5 hours;

[0044] (5) Add 1000ml of 1.2% aqueous acetic acid solution to the fine powder of the mixture obtained in (4), add 12g of glycerin, add 12g of isinglass, stir evenly, and vacuumize and degas;

[0045] (6) Pour the solution obtained in (5) into a mould, freeze at -40°C for 24 hours,...

Embodiment 3

[0046] Embodiment 3 The preparation method of the sponge biological dressing containing nano-silver, zinc, bismuth, the steps are as follows:

[0047] (1) 50g chitosan is ground into fine powder;

[0048] (2) 0.25g silver nitrate is ground into fine powder; 0.2g zinc lactate is ground into fine powder; Bismuth nitrate 0.25g is ground into fine powder;

[0049] (3) mixing the chitosan fine powder obtained in (1) with the silver nitrate fine powder, zinc lactate fine powder and bismuth nitrate fine powder obtained in (2), fully grinding for 1.5 hours;

[0050] (4) Add 0.15 g of sodium citrate to the fine powder of the mixture obtained in (3), and continue to fully grind for 3.5 hours;

[0051] (5) Add 700ml of 0.5% aqueous acetic acid solution to the fine powder of the mixture obtained in (4), add 6g of glycerin, add 6g of isinglass, stir evenly, and vacuumize and degas;

[0052] (6) Pour the solution obtained in (5) into a mold, freeze at -50°C for 24 hours, and freeze-dry at...

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Abstract

The invention discloses a preparation method of a biological dressing containing nano silver, zinc and bismuth, which comprises the steps of: synthesizing chitosan and / or a nano silver, zinc and bismuth compound as a chitosan derivative by using a solid phase synthesis method; dissolving into a solution; adding a proper quantity of glycerol, collagen and the like; and obtaining a film dressing by adopting a curtain coating film-forming method or obtaining a sponge dressing by using a freezing drying method. The biological dressing has the functions and the advantages of nano silver, zinc and bismuth, and chitosan or chitosan derivative, and has the characteristics of better contact bacteriostasis, wide antimicrobial spectrum, durable action time, wound repairmen, ulcer curing and the like.

Description

technical field [0001] The invention relates to a medical biological dressing and a preparation method thereof, which is a biological dressing containing nano-silver and zinc and bismuth metal ions, and belongs to the field of medical materials. Background technique [0002] With the in-depth research on wound healing such as skin ulcers and burns, people have realized that the purpose of using dressings is far more than just covering wounds. For decades, scholars from various countries have been committed to actively promoting wound repair through various therapies. Medical dressings Research is one of its hot spots. In recent decades, breakthroughs have been made in the research of dressings. Many new materials have been used in the production of medical dressings on a large scale, but there are still many defects. The first is the contradiction between adhesion and space occupation, followed by The anti-infection ability is weak. Although anti-infection drugs are added i...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/44
Inventor 桑青刘平倪付花陈晓霞肖庆振
Owner LIAOCHENG UNIV
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