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Adhesive patch

一种贴剂、增粘剂的技术，应用在抗炎剂、非中枢性止痛剂、非有效成分的医用配制品等方向，能够解决脱落、皮肤密接性不良、伴随疼痛等问题，达到良好贴附性、改善药物释放性和经皮吸收性、刺激持续性优异的效果

Inactive Publication Date: 2010-12-29
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In general, poultices with anti-inflammatory and analgesic effects for external use are less irritating to the skin and have an excellent cooling effect for enhancing the effect, but there is a problem of peeling off due to poor adhesion to the skin
On the other hand, a patch that contains almost no water has excellent adhesion to the skin, but it may cause pain when peeled off depending on the situation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0072] Hereinafter, the present invention will be described more specifically based on examples and comparative examples, but the present invention is not limited by the following examples.

[0073] Among the components (mass %) in the following Table 1, each component (other than the drug) constituting the adhesive layer was heated and mixed at 150 to 200° C. under an inert gas atmosphere such as nitrogen in a predetermined ratio, and after adding the drug, Stirring was carried out to obtain a homogeneous melt. Then, spread the melt on the peel-off cover, and then cover it on the polyethylene terephthalate (refer to Table 2) of double-knit weaving as a support, press and transfer the melt, and then cut Form into a square of 7×10 cm to prepare a patch.

[0074] [Table 1]

[0075]

[0076] [Table 2]

[0077]

[0078] (Measurement of storage elastic modulus)

[0079] In order to obtain the storage elastic modulus (G') at each temperature and frequency, a dynamic viscoe...

Embodiment 1

[0090] The moisture permeability of the patch of Example 1 was measured at a temperature of 40° C. and a relative humidity of 90% according to the cup method (JIS Z0208).

[0091] As a test piece, use the patch manufactured according to Example 1 and punch it into a circular object (n=3) with a diameter of about 70 mm, and as a hygroscopic agent, use anhydrous calcium chloride (the particle size is 2380 μm through a standard sieve, cut off at 590 μm) ) and Y.S. Stester No. 3525 (Yasuda Machine Co., Ltd.) was used for the cup.

[0092] First, put the glass dish containing the hygroscopic agent into the cup and place it on a level cup stand. With the support of the patch facing upward, the test piece is placed concentrically with the cup so that the guide is covered in such a way that it fits the groove of the cup table. Press the ring in line with the guide until the test piece fits tightly with the upper edge of the cup, place a weight on top, and then carefully lift the guid...

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PUM

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Abstract

An adhesive patch which comprises a substrate having stretchability and a pressure-sensitive adhesive layer superposed on at least one side of the substrate. The stretch substrate comprises a both-side-knitted woven fabric including two or more rows of a crimped polyethylene terephthalate multifilament yarn. The pressure-sensitive adhesive layer comprises 25-50 mass% liquid organic ingredient and 25-50 mass% thermoplastic elastomer based on the whole adhesive layer, the liquid organic ingredient containing at least 10 mass% methyl salicylate based on the whole adhesive layer. The pressure-sensitive adhesive layer has a storage elasticity modulus (G') as measured at 10 rad / s and 37 DEG C of 30,000-75,000 Pa.

Description

technical field [0001] The invention relates to a patch containing methyl salicylate. Background technique [0002] Conventionally, in anti-inflammatory analgesics for external use, whether it is a patch containing substantially no water in the adhesive or a poultice containing water in the adhesive, most of them contain salicylic acid compounds as active ingredients. , indomethacin, diclofenac, ketoprofen and other non-steroidal anti-inflammatory drugs and / or preparations of 1-menthol as a cooling agent. [0003] In general, poultices with anti-inflammatory and analgesic effects for external use are less irritating to the skin and have an excellent cooling effect for enhancing the effect, but they have a problem of falling off due to poor adhesion to the skin. On the other hand, a patch that does not substantially contain water has excellent adhesion to the skin, but sometimes causes pain when it is peeled off. In addition, the patch described in Patent Document 1 has bee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/618A61K9/70A61K47/32A61K47/34A61P17/00A61P29/00
CPCA61K9/7053A61K31/618A61K9/7076A61P17/00A61P29/00
Inventor 冈田知巳太田重雄堤信夫
Owner HISAMITSU PHARM CO INC
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