Method for producing L-pyroglutamic acid bivalent alkaline earth metal salt

A technology of pyroglutamic acid and divalent alkali, which is applied in the production technology field of producing divalent alkaline earth metal salt of L-pyroglutamic acid, can solve the problem of high production cost and achieve the effect of high yield

Inactive Publication Date: 2011-02-02
SHANGHAI OLI ENTERPRISES CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its yield is only 50-60%, and the production cost is higher

Method used

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  • Method for producing L-pyroglutamic acid bivalent alkaline earth metal salt
  • Method for producing L-pyroglutamic acid bivalent alkaline earth metal salt

Examples

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Effect test

Embodiment 1

[0015] The preparation of embodiment 1L-zinc pyroglutamate

[0016] In a 500L reaction kettle with a stirring and heating reflux device, add 500L of water, raise the internal temperature to 50°C, add 50kg of L-pyroglutamic acid, stir to dissolve it completely, raise the temperature to 80-85°C, and slowly add 15.9kg Zinc oxide, zinc oxide was added for about 2 hours, and stirring was continued for about 4.5 hours. The reaction is over. Cool down to 40-50°C, add 2kg of activated carbon, stir for 2 hours, stop stirring, and filter to remove the activated carbon. Evaporate under reduced pressure until the moisture content is ≤1%. The product L-zinc pyroglutamate is obtained. The yield is 92%, and the product is a white solid.

Embodiment 2

[0017] Embodiment 2: Preparation of L-calcium pyroglutamate

[0018] In a 500L reactor with stirring and heating reflux device, add 500L of water, raise the internal temperature to 50°C, add 50kg of pyroglutamic acid, stir to dissolve it completely, raise the temperature to 80-90°C, and gradually add 14kg of calcium hydroxide , the addition time of calcium hydroxide was about 1 hour, and stirring was continued for about 2 hours. The reaction is over. Cool down to 40-50°C, add 1 kg of activated carbon, stir for 1 hour, stop stirring, and filter to remove the activated carbon. Evaporate under reduced pressure until the water content is ≤0.1%. The product L-calcium pyroglutamate is obtained. The yield is 95%, and the product is a white solid.

Embodiment 3

[0019] Embodiment 3: the preparation of L-magnesium pyroglutamate

[0020] In a 500L reaction kettle with a stirring and heating reflux device, add 500L of water, raise the internal temperature to 50°C, add 100kg of pyroglutamic acid, stir to dissolve it completely, raise the temperature to 70°C, gradually add 16.8kg of magnesium oxide, add Time is about 0.5 hour, stirring is continued for about 4 hours. The reaction is over. Cool down to 40-50°C, add 0.1 g of activated carbon, stir for 1 hour, stop stirring, and filter to remove the activated carbon. Evaporate under reduced pressure at 70°C to foam, then dry under reduced pressure at 0°C, and place in a dry container. The product L-magnesium pyroglutamate was obtained. The yield is 87.5%, and the product is a white solid.

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Abstract

The invention provides a method for producing L-pyroglutamic acid bivalent alkaline earth metal salt. In the method, water is taken as a solvent, L-pyroglutamic acid is reacted with a bivalent alkaline earth metal carbonate, a bivalent alkaline earth metal oxide or an alkaline earth metal hydroxide under normal pressure, and high-yield solid, white and high-purity L-pyroglutamic acid bivalent alkaline earth metal salt is obtained through evaporation under reduced pressure.

Description

technical field [0001] The invention belongs to a method for producing divalent alkaline earth metal salt of L-pyroglutamic acid, in particular to a method for producing divalent alkaline earth metal salt of L-pyroglutamic acid with solid, high purity, good chroma and high yield technology. Background technique [0002] Divalent alkaline earth metal salts of L-pyroglutamate, especially zinc L-pyroglutamate and calcium L-pyroglutamate are widely used in cosmetics for their excellent moisturizing function and reduction of acne inflammation on the skin surface additive. Among them, L-pyroglutamic acid is an endogenous substance, which is produced by the filaggrin of skin keratinocytes under the action of protease and glutamic acid cyclase, and cross-links with the keratinocyte membrane to maintain the water content of the stratum corneum. play an important role. Therefore, L-pyroglutamic acid has been widely used in the daily chemical industry. Especially as a natural moist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/28
Inventor 崔照云黄骁
Owner SHANGHAI OLI ENTERPRISES CO LTD
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