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Diarylheptanoid compounds in curcuma zedoary and medicinal application thereof

A technology of diphenylheptane and compound, which is applied in the field of diphenylheptane compounds, and achieves the effect of good research and development prospect and novel structure

Active Publication Date: 2011-02-23
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant report on the anti-inflammatory effect of the 25 new diphenylheptane compounds involved in the present invention to inhibit the release of inflammatory mediators such as NO

Method used

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  • Diarylheptanoid compounds in curcuma zedoary and medicinal application thereof
  • Diarylheptanoid compounds in curcuma zedoary and medicinal application thereof
  • Diarylheptanoid compounds in curcuma zedoary and medicinal application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Example 1: Extraction and separation of new diphenylheptane compounds in Curcuma Curcumae in Guangxi

[0048] The medicinal material was purchased in Guilin City, Guangxi Province, and was identified as Curcuma kwangsiensis S.G.Lee et C.F.Ling by Professor Sun Qishi of the School of Traditional Chinese Medicine, Shenyang Pharmaceutical University. Rhizome 10kg, adding 70% ethanol with 3 times the weight of the raw material by weight and volume ratio and heating and refluxing for extraction 3 times, each time for 3 hours, combining the extracts, reclaiming the solvent, obtaining the ethanol extract and dispersing it in 5 times the water by weight and volume ratio, respectively Extract 3 times with cyclohexane equal to the volume of water, then extract the extracted water phase 3 times with ethyl acetate equal to the volume of water, combine the ethyl acetate extracts, and recover the solvent to obtain the total ethyl acetate extract 65g (EE), the extracted aqueous phase ...

Embodiment 2

[0093] Example 2: Experiment of the inhibitory activity of compounds 1-25 on the release of nitric oxide (NO) from mouse mononuclear macrophage RAW 264.7 induced by lipopolysaccharide

[0094] Mouse mononuclear macrophage RAW 264.7 (ATCC TIB-71) was cultured in 10% heat-inactivated (56°C, 30min) fetal bovine serum (FBS), 100 U / mL penicillin sodium (Gibco), 100 μg / mL streptavidin in RPMI 1640 (Gibco) medium, 37°C, 5% CO Z grown in a constant temperature incubator. Because NO is extremely unstable, it is quickly metabolized into nitrous acid (NO) in the cell culture supernatant. 2 - ), so the Griess method was used to measure NO in the sample 2 - concentration as an indicator of NO levels. Griess reagent A: 0.1% N-naphthalene diamine dihydrochloride (naphthylene diamine dihydrochloride) dissolved in water: Griess reagent B: 1% p-aminobenzenesulfonamide (sulphanilamide) dissolved in 5% H 3 PO 4 middle. Mix reagents A and B in equal volumes before use. Dilute RAW 264.7 ce...

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Abstract

The invention belongs to the technical field of medicines and discloses new diarylheptanoid compounds extracted and separated from Guangxi curcuma zedoary and application thereof in the field of medicines. The chemical structure of the diarylheptanoid compounds is determined by spectrum technology such as a high resolution mass spectrum, one-dimensional and two-dimensional nuclear magnetic resonance spectrum and the like, and a chemical method. The diarylheptanoid compounds can be combined with a pharmaceutically acceptable carrier to prepare clinically acceptable medicines for anti-inflammatory treatment. Experiments for inhibiting lipopolysaccharide-induced rat macrophage from synthesizing nitric oxide (NO) in vitro prove that: the diarylheptanoid compounds have high activity of inhibiting the nitric oxide from being generated, and can be used as anti-inflammatory medicines for preventing and / or treating human and animals.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to diphenylheptane compounds in zedoary and its application. technical background [0002] Inflammation is a series of protective responses of the body to the damage caused by various inflammatory factors, and the vascular response is the central link of the inflammatory process. Inflammation usually causes a systemic reaction, which is usually characterized by fever, increased white blood cell count, and in severe cases, degeneration, necrosis, and dysfunction of the heart, liver, and kidneys to varying degrees. Acute inflammation mainly manifests as redness, swelling, heat, pain and dysfunction, which is a defense response of the body to stimulation. However, chronic inflammation is characterized by the persistence of inflammatory factors and damage to the body, which can lead to chronic cholecystitis, diabetes, chronic pyelonephritis, lung diseases, cancer, diseases of the card...

Claims

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Application Information

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IPC IPC(8): C07C45/78A61K31/085C07C43/23C07C67/48C07C49/255C07C39/15A61K31/05A61K31/12A61P29/00A61K31/09C07C37/70A61K31/222C07C39/21C07C49/248C07C69/21C07C41/34
Inventor 邱峰李军康宁陈丽霞
Owner SHENYANG PHARMA UNIVERSITY
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