31results about How to "Good research and development prospects" patented technology

The invention belongs to the technical field of traditional Chinese medicine extraction, and discloses a lathyrane compound and an extraction method and application thereof. The compound has a structure of (I), wherein R1 and R2 are as described in the claims and the specification. The compound and the composition thereof have an inhibiting effect on nitric oxide generated by LPS-induced human macrophages (RAW264.7), which indicates that the compound has an anti-inflammatory effect and can be used for preparing anti-inflammatory drugs for treating autoimmune diseases or immune injuries.

The invention belongs to the technical field of medical technology, and relates to novel compounds, which are shown in a general formula (I) and have the activity of resisting influenza A(H1N1) virus, wherein R1 and R2 are defined as in the specification. The invention also relates to application and a preparation method of the compounds, and clinically acceptable medicines for treating infectious diseases of influenza A(H1N1) virus, which are prepared by combining the compounds with pharmaceutically acceptable carriers. The structure of formula (I) is shown in the specification.

The invention discloses an iridoid glycoside compound, which is a novel chemical component discovered from cape jasmines. The compound separated by virtue of the method is further structurally identified by virtue of measures of physicochemical properties and modern spectroscopy. Activity evaluation is further carried out by virtue of activity screening systems such as an LPS-induced RAW 264.7 cell inflammation model so as to discover that the compound has a certain protecting effect on a mouse macrophage system RAW 264.7, is capable of remarkably inhibiting PGE2 and presents a relatively strong anti-inflammatory action.

The invention discloses a benzylisoquinoline alkaloid compound which has a human carboxylesterase 2(hCE2) inhibiting effect and is shown as a formula (I), a plant extract containing the benzylisoquinoline alkaloid compound, a pharmaceutical composition containing the benzylisoquinoline alkaloid compound, and application of the benzylisoquinoline alkaloid compound in preparation of a human carboxylesterase 2(hCE2) inhibitor.

The invention discloses houttuynoids and a preparation method and application thereof. The houttuynoids have a structural formula as represented by formula (I) which is described in the invention; in the formula (I), R1 is represented by formula (I), formula (II), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX) or formula (X) as described in the invention, and R2 is hydrogen or is represented by formula (XI), formula (XII), formula (XIII) or formula (XIV) as described in the invention. 12 houttuynoids are separated from Saururaceae Houttuynia cordata Thunb. and are all furan-flavones with novel structures. An in-vitro anti-herpes simplex virus activity screening system is used for evaluating activity of the houttuynoids, and it is found that the houttuynoids can effectively inhibit a herpes simplex virus; thus, the houttuynoids have effects on preventing and treating herpes simplex virus infection, can be applied to preparation of drugs used for resisting the herpes simplex virus and have good research and development prospects.

The invention discloses an alkaloid compound, and the structure identification of the isolated compound is carried out by means of physicochemical properties and modern spectroscopy methods. The invention also uses the activity screening system of LPS-induced RAW 264.7 cell inflammation model to evaluate its activity, and it is found that the compound has a certain protective effect on the mouse macrophage cell line RAW 264.7, can significantly inhibit PGE2, and shows a strong Anti-inflammatory effect.

The invention which belongs to the technical field of medicines relates to new compounds with the anti-HSV activity and having a general formula represented by formula (I). R in the formula (I) is defined in the specification. The invention also relates to a use and preparation methods of the compounds, and an application of the compounds in the clinical preparation of clinically acceptable medicines for treating HSV-infected diseases through combining the compounds with pharmaceutically acceptable carriers. The structure of the general formula (I) is shown in the specification.

The invention discloses an iridoid glycoside compound, which is a new chemical component found in gardenia. In the present invention, the structure identification of the compound separated by the above method is also carried out through physical and chemical properties and modern spectroscopy means. The present invention also uses LPS-induced RAW 264.7 cell inflammation model and other activity screening systems for activity evaluation, and finds that the compound has a certain protective effect on the mouse macrophage cell line RAW 264.7, and can significantly inhibit PGE 2 , showing a strong anti-inflammatory effect.

The invention discloses a mixed-source terpenoid compound with the function of protecting the liver. The mixed-source terpenoid compound has the structures shown in formula (I) and formula (II): experiments prove that the formula (I) and formula (II) of the present invention The mixed-source terpenoids shown in (II) have significant protective effects on the liver cell damage caused by paracetamol, suggesting that the mixed-source terpenoids shown in formula (I) and formula (II) can be used as liver-protecting drugs with good research and development prospects.

The invention discloses a preparation method and application of grosvenoria grosvenori flower in water pipes of flower and fruit burning and smoking category, comprising the following steps: (a) cracking the dried fruit of grosvenoria grosvenori into pieces → loading samples → adding tap water → standing, soaking for 24-48 hours (b) Use water bath heating extraction method (extract once) → leachate → filter with 400 mesh filter cloth, seal and stand still to obtain filtrate A, (c) add 50% ethanol solution → acid precipitation extraction, fully stir → filtrate; (d) Filtrate A → Concentrate under reduced pressure at 55-60°C for 3 hours → obtain concentrated solution A (relative density ρ=1.2918), (e) add concentrated solution A to raw material 20% propylene glycol 60g → shake well → obtain concentrated solution A, the density is measured as : ρ=1.1286, (f) The obtained concentrated solution A is the natural plant Luo Han Guo extract for the preparation of Arabian hookah. The present invention can effectively improve the aroma quality, aroma quantity, fineness and / or sweetness of the hookah, reduce the irritation and / or burnt gas of the Arabian hookah, and improve the sensory quality of the hookah.

The invention belongs to the technical field of medicines and discloses new diarylheptanoid compounds extracted and separated from Guangxi curcuma zedoary and application thereof in the field of medicines. The chemical structure of the diarylheptanoid compounds is determined by spectrum technology such as a high resolution mass spectrum, one-dimensional and two-dimensional nuclear magnetic resonance spectrum and the like, and a chemical method. The diarylheptanoid compounds can be combined with a pharmaceutically acceptable carrier to prepare clinically acceptable medicines for anti-inflammatory treatment. Experiments for inhibiting lipopolysaccharide-induced rat macrophage from synthesizing nitric oxide (NO) in vitro prove that: the diarylheptanoid compounds have high activity of inhibiting the nitric oxide from being generated, and can be used as anti-inflammatory medicines for preventing and / or treating human and animals.

The invention discloses a pharmaceutical composition and application thereof in preparation of anti-osteoporosis drugs. The pharmaceutical composition is prepared from the following components in parts by mass: 7.64 to 40.90 parts of mangiferin, 4.26 to 7.39 parts of tetrahydroepiberberine, 24.33 to 35.31 parts of phellodendrine, 10.11 to 14.64 parts of magnoflorine, 2.30 to 4.26 parts of 13-hydroxyl oxidized berberine, 0.12 to 0.29 part of palmatine and 17.96 to 30.71 parts of berberine. The pharmaceutical composition not only can significantly reduce blood sugar, but also can significantly improve the skull area and skull optical density of the zebra fish with diabetic osteoporosis; the activity of alkaline phosphatase is improved, and bone formation related gene expression is promoted; the activity of tartrate-resistant acid phosphatase is reduced, and the expression of bone resorption related genes is reduced; the traditional Chinese medicine composition is safe and reliable to use, and has a good research and development prospect of anti-osteoporosis medicines.

The invention discloses an alkaloid dimer compound with PD-1 / PD-L1 binding inhibitory effect, and the alkaloid dimer compound has the structure shown in the following formula: The polymer compounds have a significant inhibitory effect on PD-1 / PD-L1 binding, suggesting that these alkaloid dimer compounds can be used as PD-1 / PD-L1 binding inhibitors in tumors, inflammatory diseases, autologous Treatment of immune diseases, bacterial infections, viral infections, fungal infections and other diseases.

The invention discloses a curcumenol microbial conversion derivative, and a preparation method and a use thereof. The above conversion product has a structure represented by formula (I) or formula II, has higher polarity and more modification sites than curcumenol, can be easily processed to prepare preparations, and can be further structure-derived. A substrate curcumenol is biologically converted by using Penicillium urticae IFFI 04015, Cunninghamella echinulata AS 3.3400 and Mucor polymorphosporus AS 3.3443, an organic solvent is used to extract the conversion product in a fermentation liquid, and chromatography is used to separate and purify the conversion product. The curcumenol conversion product can be used for preventing and / or treating inflammations caused by nitrogen monoxide inflammation mediator release, and preparing anti-inflammatory drugs.

The invention discloses a preparation method and application of momordica grosvenori flower in a flower and fruit hookah, which comprises the following steps: (a) crushing dried fruit of momordica grosvenori, loading a sample, adding tap water, standing, soaking for 24-48 hours; (b) adopting a water bath heating extraction method (extracting for one time), leaching solution, filtering with 400-mesh filter cloth, sealing and standing to obtain a filtrate A; (c) adding a 50% ethanol solution, carrying out acid precipitation extraction, fully stirring and filtering; (d) concentrating filtrate A under reduced pressure at 55-60 DEG C for 3 hours to obtain a concentrated solution A (relative density rho=1.2918); (e) adding 20% propylene glycol into the concentrated solution A, and fully shakingto obtain a concentrated solution A, wherein the density is measured as rho=1.1286; (f) obtaining the concentrated solution A as a natural plant momordica grosvenori extract for preparing Arabic hookah. The preparation method can effectively improve the quality of the hookah, the quantity of the hookah, the fineness and / or the sweetness of the hookah; the preparation method can reduce the irritation and / or the dry coke gas of the flower and fruit Arabic hookah, and can improve the sensory quality of the hookah.

The invention discloses an alkaloid compound. The separated compound undergoes structural identification through physicochemical properties and modern spectroscopy means. In addition, an activity screening system of an LPS-induced RAW 264.7 cell inflammation model is used for evaluating the activity of the compound, and it is found that the compound has a certain protection effect on a mouse macrophage line RAW 264.7, can remarkably inhibit PGE2 and shows a high anti-inflammatory effect.

The invention provides an aircraft takeoff-landing magnetorheological fluid boosting / damping runway of an aircraft carrier. The runway is formed by assembling magnetorheological fluid boosting / damping units. Each magnetorheological fluid boosting / damping unit is composed of a radar probe, a damping magnetorheological fluid pack, a protection mat, a magnetorheological fluid control device, a closed side guard, a magnetorheological fluid delivery pipe, an accumulator, a control ECU, an electric / power generating hydraulic pump, a reflux accumulation magnetorheological fluid pack, a reflux accumulation magnetorheological fluid pack electromagnetic extrusion device, a pressure sensor and the like, the bottom surface of the damping magnetorheological fluid pack communicates with the magnetorheological fluid delivery pipe, and the magnetorheological fluid delivery pipe passes through the magnetorheological fluid control device, and communicates with the reflux accumulation magnetorheological fluid pack after being connected with the electric / power generating hydraulic pump in series. According to the invention, landing damping and takeoff boosting can be realized for an aircraft, the instantaneous impact momentum of bullets, that is shrapnels is absorbed, and the momentum passes a circulation liquid flow generating system after being absorbed. Compared with the current aircraft carrier arresting cable, the runway is simple in structure, does not cause casualties, and has good research and development prospects.

The invention discloses a microbial conversion product of curcumenol, its use and preparation method. The structure of the transformation product is 1 α -Hydroxycurcumenol. The conversion product 1 α -Hydroxycurcumenol can be used as an anti-inflammatory drug for the prophylaxis and / or treatment of humans and animals. Mucor echinocystis Mucor ? spinosus? AS? 3.2450 biotransforms the substrate curcumenol, and uses ethyl acetate to extract the converted product in the fermentation broth, and uses silica gel column chromatography to separate and purify the converted product. The obtained conversion product has a purity of over 98%.

The invention discloses a sesquiterpene compound with lipase inhibitory effect. This type of sesquiterpene compound has the structures shown in formula (I) and formula (II): experiments have proved that formula (I) and formula (II) of the present invention The lipase activity of the sesquiterpenoids shown in formula (II) has significant inhibitory effect, suggesting that the sesquiterpenoids shown in formula (I) and formula (II) can be used as blood lipid-lowering, anti-obesity drugs or health products, with Good prospects for research and development.

The invention discloses physapubescin, and an extraction method and application thereof. The physapubescin has a structure as shown in a formula (I) which is described in the specification. Experimental results show that the physapubescin as shown in the formula (I) and physapubescin aglycon as shown in a formula (II) can inhibit the activity of lipopolysaccharide in induction of mouse macrophagesto release nitric oxide, so it is proved that the physapubescin as shown in the formula (I) and the physapubescin aglycon as shown in the formula (II) can be used as anti-inflammatory drugs; and theresults of activity evaluation via an in-vitro antitumor activity screening system show that the physapubescin as shown in the formula (I) and the physapubescin aglycon as shown in the formula (II) can effectively inhibit the growth of hormone-independent prostate cancer cells, different types of renal cancer cells and human malignant melanoma cells, so it is proved tha the physapubescin as shownin the formula (I) and the physapubescin aglycon as shown in the formula (II) can be used as medicines for treating tumors and have good research and development prospects.

The embodiments of the invention disclose an antitumor compound, an extraction method therefor and an application of the antitumor compound. The compound has a structure represented by a general formula (I) shown in the description or a general formula (II) shown in the description and an optical isomer of the general formula (I) or general formula (II). The compound disclosed by the invention and compositions thereof can be used for effectively inhibiting the growth of hormone-independent prostatic carcinoma cells, heterogeneous renal carcinoma cells and human malignant melanoma cells, so that the compound disclosed by the invention and the compositions thereof can serve as drugs for treating tumors and have a good research and development prospect.

The invention which belongs to the technical field of medicines relates to new compounds with the anti-HSV activity and having a general formula represented by formula (I). R in the formula (I) is defined in the specification. The invention also relates to a use and preparation methods of the compounds, and an application of the compounds in the clinical preparation of clinically acceptable medicines for treating HSV-infected diseases through combining the compounds with pharmaceutically acceptable carriers. The structure of the general formula (I) is shown in the specification.

The invention belongs to the technical field of medical technology, and relates to novel compounds, which are shown in a general formula (I) and have the activity of resisting influenza A(H1N1) virus, wherein R1 and R2 are defined as in the specification. The invention also relates to application and a preparation method of the compounds, and clinically acceptable medicines for treating infectious diseases of influenza A(H1N1) virus, which are prepared by combining the compounds with pharmaceutically acceptable carriers. The structure of formula (I) is shown in the specification.