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New application of sulfadiazine sodium in preparing medicine for preventing or treating Bombyx mori septicemia

A technology for sulfadiazine sodium and septicemia, which is applied in the field of sulfadiazine sodium, can solve the problems that the treatment effect is only achieved, the treatment effect is not very good, etc., so as to reduce the loss of silkworm disease, improve the yield and quality of silkworm cocoons, and reduce the loss of silkworm disease. rate effect

Inactive Publication Date: 2012-10-31
HUBEI AGRI BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the therapeutic effect of ciprofloxacin hydrochloride on silkworm septicemia is not very good, and when the concentration is 200mg / L, the therapeutic effect only reaches 85.59%; blood disease and black chest septicemia, and there is no drug on the market that can prevent or cure both diseases at the same time

Method used

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  • New application of sulfadiazine sodium in preparing medicine for preventing or treating Bombyx mori septicemia
  • New application of sulfadiazine sodium in preparing medicine for preventing or treating Bombyx mori septicemia
  • New application of sulfadiazine sodium in preparing medicine for preventing or treating Bombyx mori septicemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The use of sulfadiazine sodium in the preparation of medicines for preventing or treating silkworm septicemia, specifically, the medicine contains 2.0% by weight of sulfadiazine sodium, and the rest are auxiliary materials. The auxiliary materials are starch with a content of 98% %.

[0023] Drug efficacy test method:

[0024] Inoculate the test bacteria on the nutrient agar slant medium and culture for 24 hours. During the test, rinse the bacterial lawn with 2mL sterile water to make a bacterial suspension, dilute the bleeding bacteria 100 times, and dip it with an inoculation needle sterilized by an alcohol lamp flame. A small amount of bacterial solution was used to puncture and inoculate the 5th instar silkworm under the body surface.

[0025] The above-mentioned medicine containing sulfadiazine sodium is formulated into a solution containing 200 mg / L of pyrimidine-sulfadiazine sodium, and the mulberry leaves are respectively soaked in the medicine solution, then d...

Embodiment 2

[0035] The use of sulfadiazine sodium in the preparation of medicines for preventing or treating silkworm septicemia, specifically, the medicine contains 2.5% by weight of sulfadiazine sodium, and the rest are auxiliary materials. The auxiliary materials are starch with a content of 97.5% %.

[0036] Drug efficacy test method:

[0037] Inoculate the test bacteria on the nutrient agar slant medium and culture for 24 hours. During the test, rinse the bacterial lawn with 2mL sterile water to make a bacterial suspension, dilute the bleeding bacteria 100 times, and dip it with an inoculation needle sterilized by an alcohol lamp flame. A small amount of bacterial solution was used to puncture and inoculate the 5th instar silkworm under the body surface.

[0038] The above-mentioned medicine containing sulfadiazine sodium is formulated into a solution containing 250 mg / L of pyrimidine-sulfadiazine sodium, and the mulberry leaves are respectively soaked in the medicine solution, then...

Embodiment 3

[0048] The use of sulfadiazine sodium in the preparation of medicines for preventing or treating silkworm septicemia, specifically, the medicine contains 5.0% by weight of sulfadiazine sodium, and the rest are auxiliary materials. The auxiliary materials are starch with a content of 95%. %.

[0049] Drug efficacy test method:

[0050] Inoculate the test bacteria on the nutrient agar slant medium and culture for 24 hours. During the test, rinse the bacterial lawn with 2mL sterile water to make a bacterial suspension, dilute the bleeding bacteria 100 times, and dip it with an inoculation needle sterilized by an alcohol lamp flame. A small amount of bacterial solution was used to puncture and inoculate the 5th instar silkworm under the body surface.

[0051] The above-mentioned medicine containing sulfadiazine sodium was made into a solution containing 500 mg / L of pyrimidine-sulfadiazine sodium, and the mulberry leaves were respectively soaked in the medicine solution, then drie...

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Abstract

The invention discloses an application of sulfadiazine sodium in medicines for preventing or treating silkworm bacillus prodigiosus septicemia caused by bacteria. The medicine solution, in which the concentration of sulfadiazine sodium is 200-500 mg / L, has favorable effect on preventing and treating silkworm bacillus prodigiosus septicemia caused by the bacteria. The invention also discloses a composition capable of preventing and treating silkworm septicemia. The composition uses sulfadiazine sodium and enrofloxacin as the active ingredients, and also uses trimethoprim and auxiliary materials. The medicine composition can be used for simultaneously treating black-chest septicemia and bacillus prodigiosus septicemia of domestic silkworm.

Description

technical field [0001] The invention relates to a new application of sulfadiazine sodium, in particular to an application in the preparation of medicines for preventing or treating silkworm bleeding septicemia. Background technique [0002] Sericulture plays an important role in the national economy. Among the many factors affecting the overall economic benefits of my country's silk industry, the harm of silkworm disease is one of the main factors. According to incomplete statistics, the current silkworm disease loss rate in my country is about 15%. According to the current annual output of 440,000 tons of cocoons in my country, the annual loss of silkworm cocoons due to silkworm diseases is as high as 60,000 tons, worth more than 800 million yuan. As a result, the quality of cocoon silk is low, and the losses caused to the entire industry are even more incalculable. [0003] Among the common silkworm diseases, bacterial disease is one of the long-standing and serious disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61P31/04
Inventor 吴洪丽孙波周洪英叶建美许淑琼陈登松胡兴明
Owner HUBEI AGRI BIOCHEM