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Emollient composition

A composition and drug technology, applied in the direction of drug combination, skin care preparations, active ingredients of hydrocarbon compounds, etc., can solve the problem that the barrier is not absolute

Inactive Publication Date: 2011-04-20
PIERRE FABRE DERMO COSMETIQUE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the barrier against water loss is not absolute

Method used

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  • Emollient composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1: Formulation

[0077] Composition A

[0078] - 15 g of glycerol,

[0079] - 8 grams of petroleum jelly,

[0080] - 2 g of liquid paraffin,

[0081] - 0.5 g of triethanolamine,

[0082] - and the following components as excipients: stearic acid, glyceryl monostearate, dimethicone, dimethicone, polyethylene glycol (PEG) 600, p-hydroxybenzene Propyl formate,

[0083] - Water up to 100 g.

[0084] Composition A'

[0085] - 15 g of glycerol,

[0086] - 8 grams of petroleum jelly,

[0087] - 2 g of liquid paraffin,

[0088] - 1.5 g of stearic acid,

[0089] - 5 g of glyceryl monostearate,

[0090] - 1.5 g of dimethicone,

[0091] - 0.5 g of dimethicone,

[0092] - 5 g of macrogol 600,

[0093] - 0.15 g of triethanolamine,

[0094] - 0.1 g of propyl paraben,

[0095] - Water up to 100 g.

[0096] Composition B

[0097] - 15 g of glycerol,

[0098] - 8 grams of petroleum jelly,

[0099] - 2 g of liquid paraffin,

[0100] - 0.5 g of PEG-40-stearate...

Embodiment 2

[0116] Example 2: Analysis of regulation of induced skin dehydration

[0117] Here, we evaluated the hydration activity of Composition A and the resulting improvement in skin barrier function by using an in vitro skin model of induced skin dehydration.

[0118] We observed the expression of differential molecular epidermal markers by quantitative PCR and immunohistochemistry.

[0119] We also tracked serine protease activity by in situ zymography and corneal desmosomal protein degradation by Western blotting.

[0120] The function of the skin barrier was analyzed by using fluorescent probes.

[0121] Materials and methods

[0122] 1. Organization model

[0123] 1. Preparation of skin grafts

[0124] The laboratory recovered skin samples from plastic surgery (breast reduction) procedure waste. The use of these samples falls under "the declaration of an activity for preserving and preparing elements of the human body required for research protocols of the Pierre Fabre group...

Embodiment 3

[0166] Example 3: Characterization of Syntadex A petrolatum by NMR

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Abstract

The invention relates to an emollient composition for topical use that comprises a combination of glycerol, Vaseline and liquid paraffin as an active principle, in the form of an oil-in-water or water-in-oil emulsion. The invention also relates to: the use thereof for preparing a drug for treating dry skin conditions associated with certain dermatoses such as atopic dermatitis, ichthyosis conditions and psoriasis; the use thereof for preparing a drug for treating small superficial burns; and the use thereof for preparing a drug for preventing and / or treating and / or reducing the frequency and intensity of eczema attacks observed in patients suffering from atopic dermatitis.

Description

technical field [0001] The present invention relates to the field of treatment of pathologies and conditions associated with the barrier function of infected skin. Background technique [0002] The epidermis is a stratified epithelium of ectoderm origin that undergoes continuous renewal. [0003] It protects the body against dehydration, mechanical stress and certain pathogenic attacks. [0004] It is composed of several cell types: more than 90% keratinocytes, as well as Langerhans cells, Merkel cells, and melanocytes. [0005] Several layers of different morphological properties and cellular composition can be divided from the inside to the outside: the basal layer (which is the cellular layer whose keratinocytes have a very strong proliferative capacity, which ensures the self-renewal of the epidermis), followed by the suprabasal layer The bottom layer (granular layer, epidermal germinal layer) and finally the stratum corneum (SC). [0006] One of the fundamental funct...

Claims

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Application Information

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IPC IPC(8): A61K31/01A61K31/047A61P17/02A61P17/06A61K8/30A61K8/92
CPCA61K8/345A61Q19/007A61K31/047A61K8/31A61K31/01A61P17/00A61P17/02A61P17/04A61P17/06A61P17/16A61K2300/00
Inventor P·法夫雷C·普日贝尔斯基J-F·科尔多利安尼M·科佩茨
Owner PIERRE FABRE DERMO COSMETIQUE CORP
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